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Philip V. Bayly Ph.D.

Hughes Professor of Mechanical Engineering; Professor of Biomedical Engineering

Department:Mechanical & Aerospace Engineering
Email:pvb@wustl.edu
Websites:http://biomechanics.wustl.edu/faculty/bayly/
http://www.me.wustl.edu/faculty/pvb/index.html
Office Phone:314-935-6081
Fax:314-935-4014

Biomechanical factors in traumatic injury to the brain and spinal cord

The Bayly lab investigates the application of nonlinear dynamics and vibrations to mechanical and biomedical systems including the biomechanics of brain development, MR imaging of gyrogenesis (cortical folding), measurement of mechanical properties in the developing brain, and simulation of growth and morphogenesis.

Additionally, Bayly researches the dynamics of the brain through MR imaging and analysis of motion. His studies include those examining brain deformation during head acceleration and impact impact, intracranial strain in mouse models of concussion, tagged magnetic resonance imaging of strain in accelerating human and animal brains, and MR elastography.

His brain-dynamics team has observed how human brains respond to voluntary skull acceleration. This research has uncovered explanations of unexpected brain-injury patterns.

 Program Affiliations

 Hope Center Affiliations

organizationrole
Bayly Lab

 Selected Publications available on PubMed

Anisotropic mechanical properties of magnetically aligned fibrin gels measured by magnetic resonance elastography.
Namani R, Wood MD, Sakiyama-Elbert SE, Bayly PV
Journal of biomechanics.  2009 Sep 18;42(13):2047-53. Epub 2009 08 05.
Characterization of brain development in the ferret via MRI.
Barnette AR, Neil JJ, Kroenke CD, Griffith JL, Epstein AA, Bayly PV, Knutsen AK, Inder TE
Pediatric research.  2009 Jul ;66(1):80-4.
A new method for measuring deformation of folding surfaces during morphogenesis.
Filas BA, Knutsen AK, Bayly PV, Taber LA
Journal of biomechanical engineering.  2008 Dec ;130(6):061010. PMCID: PMC2649008
Quantitative panoramic imaging of epicardial electrical activity.
Lou Q, Ripplinger CM, Bayly PV, Efimov IR
Annals of biomedical engineering.  2008 Oct ;36(10):1649-58. Epub 2008 07 25. PMCID: PMC2714651
Residual stress in the adult mouse brain.
Xu G, Bayly PV, Taber LA
Biomechanics and modeling in mechanobiology.  2009 Aug ;8(4):253-62. Epub 2008 07 24.
Constrained tibial vibration in mice: a method for studying the effects of vibrational loading of bone.
Christiansen BA, Bayly PV, Silva MJ
Journal of biomechanical engineering.  2008 Aug ;130(4):044502.
Measurement of the dynamic shear modulus of mouse brain tissue in vivo by magnetic resonance elastography.
Atay SM, Kroenke CD, Sabet A, Bayly PV
Journal of biomechanical engineering.  2008 Apr ;130(2):021013. PMCID: PMC2408772
Deformation of the human brain induced by mild angular head acceleration.
Sabet AA, Christoforou E, Zatlin B, Genin GM, Bayly PV
Journal of biomechanics.  2008;41(2):307-15. Epub 2007 10 24. PMCID: PMC2701725
Electromagnetic controlled cortical impact device for precise, graded experimental traumatic brain injury.
Brody DL, Mac Donald C, Kessens CC, Yuede C, Parsadanian M, Spinner M, Kim E, Schwetye KE, Holtzman DM, Bayly PV
Journal of neurotrauma.  2007 Apr ;24(4):657-73. PMCID: PMC2435168
Detection of traumatic axonal injury with diffusion tensor imaging in a mouse model of traumatic brain injury.
Mac Donald CL, Dikranian K, Song SK, Bayly PV, Holtzman DM, Brody DL
Experimental neurology.  2007 May ;205(1):116-31. Epub 2007 02 12. PMCID: PMC1995439
Spatiotemporal evolution of apoptotic neurodegeneration following traumatic injury to the developing rat brain.
Bayly PV, Dikranian KT, Black EE, Young C, Qin YQ, Labruyere J, Olney JW
Brain research.  2006 Aug 30;1107(1):70-81. Epub 2006 07 05. PMCID: PMC2376971
In vivo imaging of rapid deformation and strain in an animal model of traumatic brain injury.
Bayly PV, Black EE, Pedersen RC, Leister EP, Genin GM
Journal of biomechanics.  2006;39(6):1086-95. PMCID: PMC1479313
Harmonic phase MR tagging for direct quantification of Lagrangian strain in rat hearts after myocardial infarction.
Liu W, Chen J, Ji S, Allen JS, Bayly PV, Wickline SA, Yu X
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine.  2004 Dec ;52(6):1282-90.
Measurement of strain in physical models of brain injury: a method based on HARP analysis of tagged magnetic resonance images (MRI).
Bayly PV, Ji S, Song SK, Okamoto RJ, Massouros P, Genin GM
Journal of biomechanical engineering.  2004 Aug ;126(4):523-8. PMCID: PMC2408558
Multiple episodes of mild traumatic brain injury result in impaired cognitive performance in mice.
Creeley CE, Wozniak DF, Bayly PV, Olney JW, Lewis LM
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.  2004 Aug ;11(8):809-19.
Linear and angular head accelerations during heading of a soccer ball.
Naunheim RS, Bayly PV, Standeven J, Neubauer JS, Lewis LM, Genin GM
Medicine and science in sports and exercise.  2003 Aug ;35(8):1406-12.