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Faculty Profile

Kendall Blumer Ph.D.

Professor of Cell Biology and Physiology

Department:Cell Biology & Physiology
Email:kblumer@cellbiology.wustl.edu
DBBS Profile:View On DBBS Website
Office Phone:(314)362-1668
Lab Phone:(314)362-1662
Fax:(314)362-7463

 Program Affiliations

 Hope Center Affiliations
organizationrole
Blumer Lab

 Selected Publications available on PubMed
R9AP and R7BP: traffic cops for the RGS7 family in phototransduction and neuronal GPCR signaling.
Jayaraman M, Zhou H, Jia L, Cain MD, Blumer KJ
Trends in pharmacological sciences.  2009 Jan ;30(1):17-24. Epub 2008 11 29.
An adrenaline (and gold?) rush for the GPCR community.
Blumer KJ, Thorner J
ACS chemical biology.  2007 Dec 21;2(12):783-6.
Regulation of RGS2 and second messenger signaling in vascular smooth muscle cells by cGMP-dependent protein kinase.
Osei-Owusu P, Sun X, Drenan RM, Steinberg TH, Blumer KJ
The Journal of biological chemistry.  2007 Oct 26;282(43):31656-65. Epub 2007 08 06.
R7BP augments the function of RGS7*Gbeta5 complexes by a plasma membrane-targeting mechanism.
Drenan RM, Doupnik CA, Jayaraman M, Buchwalter AL, Kaltenbronn KM, Huettner JE, Linder ME, Blumer KJ
The Journal of biological chemistry.  2006 Sep 22;281(38):28222-31. Epub 2006 07 25.
Actin-based motility during endocytosis in budding yeast.
Kim K, Galletta BJ, Schmidt KO, Chang FS, Blumer KJ, Cooper JA
Molecular biology of the cell.  2006 Mar ;17(3):1354-63. Epub 2006 01 04. PMCID: PMC1382323
Oligomerization of G-protein-coupled receptors: lessons from the yeast Saccharomyces cerevisiae.
Overton MC, Chinault SL, Blumer KJ
Eukaryotic cell.  2005 Dec ;4(12):1963-70. PMCID: PMC1317502
A WASp-binding type II phosphatidylinositol 4-kinase required for actin polymerization-driven endosome motility.
Chang FS, Han GS, Carman GM, Blumer KJ
The Journal of cell biology.  2005 Oct 10;171(1):133-42. PMCID: PMC2171216
Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family.
Drenan RM, Doupnik CA, Boyle MP, Muglia LJ, Huettner JE, Linder ME, Blumer KJ
The Journal of cell biology.  2005 May 23;169(4):623-33. Epub 2005 05 16. PMCID: PMC2171691
RGS2 is a mediator of nitric oxide action on blood pressure and vasoconstrictor signaling.
Sun X, Kaltenbronn KM, Steinberg TH, Blumer KJ
Molecular pharmacology.  2005 Mar ;67(3):631-9. Epub 2004 11 24.
G-protein signaling participates in the development of diabetic cardiomyopathy.
Harris IS, Treskov I, Rowley MW, Heximer S, Kaltenbronn K, Finck BN, Gross RW, Kelly DP, Blumer KJ, Muslin AJ
Diabetes.  2004 Dec ;53(12):3082-90.
The p21-activated protein kinase-related kinase Cla4 is a coincidence detector of signaling by Cdc42 and phosphatidylinositol 4-phosphate.
Wild AC, Yu JW, Lemmon MA, Blumer KJ
The Journal of biological chemistry.  2004 Apr 23;279(17):17101-10. Epub 2004 02 06.
Subunits of a yeast oligomeric G protein-coupled receptor are activated independently by agonist but function in concert to activate G protein heterotrimers.
Chinault SL, Overton MC, Blumer KJ
The Journal of biological chemistry.  2004 Apr 16;279(16):16091-100. Epub 2004 02 05.
Oligomerization, biogenesis, and signaling is promoted by a glycophorin A-like dimerization motif in transmembrane domain 1 of a yeast G protein-coupled receptor.
Overton MC, Chinault SL, Blumer KJ
The Journal of biological chemistry.  2003 Dec 5;278(49):49369-77. Epub 2003 09 23.
C5a receptor oligomerization. II. Fluorescence resonance energy transfer studies of a human G protein-coupled receptor expressed in yeast.
Floyd DH, Geva A, Bruinsma SP, Overton MC, Blumer KJ, Baranski TJ
The Journal of biological chemistry.  2003 Sep 12;278(37):35354-61. Epub 2003 06 30.
The C-terminal tail preceding the CAAX box of a yeast G protein gamma subunit is dispensable for receptor-mediated G protein activation in vivo.
Chinault SL, Blumer KJ
The Journal of biological chemistry.  2003 Jun 6;278(23):20638-44. Epub 2003 03 28.
A WASp homolog powers actin polymerization-dependent motility of endosomes in vivo.
Chang FS, Stefan CJ, Blumer KJ
Current biology : CB.  2003 Mar 18;13(6):455-63.
Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice.
Heximer SP, Knutsen RH, Sun X, Kaltenbronn KM, Rhee MH, Peng N, Oliveira-dos-Santos A, Penninger JM, Muslin AJ, Steinberg TH, Wyss JM, Mecham RP, Blumer KJ
The Journal of clinical investigation.  2003 Feb ;111(4):445-52. PMCID: PMC151918
Use of fluorescence resonance energy transfer to analyze oligomerization of G-protein-coupled receptors expressed in yeast.
Overton MC, Blumer KJ
Methods (San Diego, Calif.).  2002 Aug ;27(4):324-32.
The extracellular N-terminal domain and transmembrane domains 1 and 2 mediate oligomerization of a yeast G protein-coupled receptor.
Overton MC, Blumer KJ
The Journal of biological chemistry.  2002 Nov 1;277(44):41463-72. Epub 2002 08 22.