James Galvin, MD, MPH, always wanted to be a doctor. But it was his father's own battle with Parkinson's disease that convinced the New Jersey native to become a neurologist. Galvin's research at the Hope Center seeks better treatments for people with neurodegenerative diseases like Alzheimer's and Parkinson's. Read More >

The ability to remember word lists and other tests of episodic memory are commonly used to detect early signs of Alzheimer's disease. But Hope Center investigator James Galvin, MD, MPH, may have found a way of detecting the mental changes associated with Alzheimer's Disease years earlier. Read More >

Like humans with ALS, the new mouse engineered by Hope Center investigator Robert Baloh, MD, PhD, develops progressive paralysis; loses muscle mass and motor neurons, and eventually dies of the disorder. These similarities to human ALS make it an exceptional model for developing and testing new treatments for human ALS. Read More >

Jeffery Milbrandt, MD, Ph.D, will succeed interim head of Genetics Susan Dutcher, Ph.D., who has held the position since June 2006. In addition to being a Hope Center investigator, Milbrandt serves on the Hope Center's steering committee. Read More >

Gregory Zipfel, M.D., was drawn to Washington University by the opportunity to both practice clincial medicine and conduct high level research. In this interview, Zipfel, a Hope Center researcher, talks about his background, accomplishments, and interests in and out of the lab. Read More >

Neurodegenerative disorders like Alzheimer's disease and Parkinson's disease often disrupt sleep. New findings from the lab of David Holtzman, M.D., are some of the first indications that sleep loss could play a role in the genesis of such disorders. Holtzman is a Hope Center researcher and steering committee member. Read More >

Graduate fellow Alexis Webb, working with Hope Center researcher Erik Herzog, Ph.D. and others, has shown that individual cells keep time on their own - even when isolated from the body's biological clock. Read More >

More research on Alzheimer's Disease is crucial if we are to move beyond delaying its effects and comforting those affected. James E. Galvin, M.D., MPH, sees hope in earlier diagnosis and increases in enrollment in clinical trials. Galvin is an Alzheimer's researcher at the Hope Center and Director of the Memory Diagnostic Center. Read More >

Hope Center researchers Christina Gurnett, M.D., Ph.D. and Liu Lin Thio, M.D., Ph.D., are part of a group of researchers and clinicians who have created the first-ever registry to track a severe type of epilepsy that strikes infants within their first few months of life. Read More >

Hope Center researcher Susan Mackinnon, MD, and Justin Brown, MD, are using newly developed nerve grafting and nerve transfer techniques to help patients of the Center for Nerve Injury and Paralysis regain movement and sensation in their nerve-damaged limbs. Read More >

What Anne Fagan, Ph.D, does depends on who you ask. At the Hope Center, Fagan is known for her research on Alzheimer's Disease, but to her son Greg's class she's simply known as the "brain lady." The dueling titles are a testament to Fagan's ability to balance her roles as outstanding scientist and mom. Read More >

Pain warns us when our body is injured, but when pain becomes chronic, it loses all usefulness and becomes debilitating. Typically, pain killers block pain receptors. But Hope Center investigator Rob Gereau is approaching the problem from a new angle: What if you could reverse the process that makes pain chronic? Read More >

Hope Center scientist Gerald W. Dorn II, M.D., has been named the Philip and Sima K. Needleman Professor of Medicine. Philip Needleman, Ph.D., chaired the Department of Pharmacology from 1976 to 1989 and is also a member of the Hope Center's executive committee. Read More >

Hope Center researcher Alison Goate, D. Phil., was one of an international team of scientists behind a new study that pooled DNA samples of 7,000 people with Alzheimer's Disease and 12,000 with no symptoms to identify genetic risk factors for the disease. Read More >

What stroke interventions are being tested in humans? Are there promising treatments on the horizon? For answers, one might check the Stroke Trials Registry hosted by the Internet Stroke Center. The Registry recently achieved a notable benchmark - 1000 entries. Read More >

Hope Center investigator Zhou-Feng Chen, Ph.D. has discovered nerve cells specific to itching - dispelling the common belief among scientists that itching is just a less intense version of pain. Read More >

In the lab of James Galvin, M.D., there is a new breed of fruit fly and an indian spice that may hold the key to treating dementia and other losses of cognitive function in people with Parkinson's Disease. Read More >

Research conducted by Hope Center Fellow Ann Stowe, Ph.D., has shown that neutrophil elastase plays a key role in brain injury that can occur following a stroke. Read More >

We at the Hope Center wish to thank everyone who helped make the Third Annual Symposium on Translational Neuroscience a great success. Read More >

Based on surveys of physicians from over 400 subspecialties of medicine, a dozen Hope Center faculty members have been listed in Best Doctors in America for 2009. Read More >

Dr. Schalggar's research on the development of the network structure of the brain in Tourettes syndrome has earned him a celebrated award from the American Academy of Neurology. Read More >

In a recent interview for the Ladue News, Anne Cross, a faculty member of the Hope Center for Neurological Disorders, expressed optimism about emerging treatments for multiple sclerosis. Read More >

Dr. David Holtzman, a Hope Center investigator and chair of the steering committee, was named one of 14 "pioneers" in biomedical research by U.S. News and World Report. Read More >

A Hope Center investigator, C. Michael Crowder M.D./Ph.D., has been named the new Brown Professor of Anesthesiology. Dr. Crowder's research investigates mechanisms of neuronal cell death after a hypoxic injury, such as a stroke. Read More >

Dr. Robert Heuckeroth, a Hope Center investigator, received an prestigious Burroughs Wellcome Fund award for his work in turning laboratory research into treatments at the patient's bedside. Read More >

Using the drug rapamycin, researchers in Hope Center investigator Michael Wong's lab prevented changes in the brains of rats that typically result from a seizure and can lead to seizures later on. Subsequent seizures in the treated rats decreased significantly. Read More >

Neurons can die if their ability to break down damaged or unneeded proteins within the cell is impaired. According to a new study published by researchers in the lab of Hope Center investigator B. Joy Snider, calcium may hold the key to protecting these neurons. Read More >

Watch "The Alzheimer's Project" on your computer. The Alzheimer’s Project is a four-part HBO documentary film series on Alzheimer's Disease including the science and research, children touched by Alzheimer’s, and people with the disease and their caregivers. Read More >

Hope Center investigators Drs. Aaron DiAntonio and Jeffrey Milbrandt have indentified the first gene that "pulls the plug" on ailing nerve branches from within the cell, a discovery that could yield greater insight into the painful nerve condition known as neuropathy. Read More >

Hope Center scientist Dr. Jeffrey Milbrandt and collaborators have discovered that an enzyme studied for years because of its potential connections to cancer, diabetes, heart disease, hypertension and stroke may also help to create and maintain the brain. Read More >

Hope Center investigators Drs. Anne Fagan and David Holtzman have linked a potential indicator of Alzheimer's disease to brain damage in humans with no signs of mental impairment. Read More >

Drs. Zhou-Feng Chen and Robyn Klein each received $30,000 grants to pursue projects related to itch and multiple sclerosis, respectively. Read More >

Hope Center scientist Dr. Jin-Moo Lee and his collaborators have found that have shown that residents with appropriate training can safely make the call, ensuring that effective treatment is delivered faster. This finding could improve the speed of stroke treatment. Read More >

The goal of the Center for Computational Biology (CCB) is to provide a common intellectual ground for biomolecular modeling and a shared infrastructure to support computational research. Read More >

Hope Center Investigator Dr. Michael Crowder works with microscopic worms able to survive in a low-oxygen environment. His research could help develop more effective therapies for conditions such as stroke and heart attack. Read More >