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Stroke 
 

Stroke or brain attack is a sudden problem affecting the blood vessels of the brain. Stroke occurs when blood vessels are ruptured (hemorrhagic stroke) or blocked (ischemic stroke).

 Hope Center Scientists and Clinicians who Work on Stroke

C. Michael Crowder M.D., Ph.D.
Associate Professor of Anesthesiology and Developmental Biology

Fundamental mechanisms of neuronal cell death following hypoxic injury

Ralph G. Dacey Jr M.D.
Henry G. and Edith R. Schwartz Professor and Chair of Neurological Surgery

Hans H. Dietrich Ph.D.
Research Assistant Professor of Neurological Surgery

Regulatory mechanisms of cerebrovascular microcirculation

Gerald W. Dorn II MD
Philip and Sima K. Needleman Professor of Medicine

Caridiac Disease and Signaling Pathways for Heart Cell Growth and Death

Simon J. Fisher Ph.D., M.D.
Assistant Professor of Medicine - Division of Endocrinology, Metabolism and Lipid Research

Jeffrey M. Gidday Ph.D.
Associate Professor of Neurological Surgery

Endogenous mechanisms of vascular and parenchymal protection in CNS ischemia.

Mark P. Goldberg M.D.
Professor of Neurology, Neurobiology, and Biomedical Engineering; Director of the Hope Center for Neurological Disorders

Mechanisms of ischemic injury and recovery in white matter axons and glia.

David M. Holtzman M.D.
Andrew B. and Gretchen P. Jones Professor and Chairman of Neurology; Professor of Molecular Biology; Hope Center Steering Committee

Cellular/Molecular/Biomarkers studies of Alzheimer's disease and neonatal brain injury.

Eugene M. Johnson Ph.D.
Professor of Neurology and Developmental Biology; Hope Center Steering Committee

Biological function and pharmacological potential of GFL neurotrophic factors

Jin-Moo Lee M.D., Ph.D.
Associate Professor of Neurology

Understanding the molecular pathogenesis of spontaneous intracerebral hemorrhage

B. Joy Snider M.D., Ph.D.
Assistant Professor of Neurology

Mechanisms of protein degradation and intracellular calcium homeostasis in neurodegenerative disorders

Michael Wong M.D., Ph.D.
Assistant Professor of Neurology and Pediatrics

Cellular mechanisms of epileptogenesis and seizure-induced brain injury

Kelvin A. Yamada M.D.
Associate Professor of Neurology and Pediatrics

Modulation and derangements of synaptic transmission at central nervous system synapses

Gregory J. Zipfel M.D.
Assistant Professor of Neurological Surgery and Neurology

Role of amyloid-B peptide and cerebral amyloid angiopathy in neurovascular dysfunction, ischemic brain injury and subarachnoid hemorrhage

 Read about Hope Center research on Stroke

Gregory Zipfel, M.D.
Stroke Center's quartered brain logo
Ann Stowe, Ph.D.
Valeria Cavalli
Jin-Moo Lee, MD, PhD
Janice Brunstrom
Brain Cells Before and After Seizure 
 Images of brain cells taken before (above) and after seizures in live mice reveal loss of spines, small bumps on the surfaces of brain cell branches.

Washington University Stroke Sites

Information about Stroke

There are several types of stroke, and each type has different causes. The three main types of stroke are listed below. Click on the individual name of each type for more detailed information and images.

Ischemic Stroke

The most common type of stroke -- accounting for almost 80% of all strokes -- is caused by a clot or other blockage within an artery leading to the brain.

Intracerebral Hemorrhage

An intracerebral hemorrhage is a type of stroke caused by the sudden rupture of an artery within the brain. Blood is then released into the brain, compressing brain structures.

Subarachnoid Hemorrhage

A subarachnoid hemorrhage is also a type of stroke caused by the sudden rupture of an artery. A subarachnoid hemorrhage differs from a intracerebral hemorrhage in that the location of the rupture leads to blood filling the space surrounding the brain rather than inside of it.

(Adapted from The Internet Stroke Center at Washington University School of Medicine.)

Stroke is the third leading cause of death in America.

Stroke can result in consequences in any part of the body controlled by the damaged part of the brain.

How is Stroke Diagnosed?

Stroke symptoms can include numbness or weakness; trouble speaking or understanding speech; tingling pains; blurry vision; trouble walking or moving; or sudden, massive, unexplained headache. Doctors stress the importance of recognizing the signs of stroke, and of calling 911 at the first signs of a stroke.

Magnetic resonance imaging (MRI’s) and other forms of brain scanning can detect clots and damage from previously undetected mini-strokes.

How is Stroke Treated?

Treatment for stroke falls into three categories: prevention, acute treatment (immediately after a stroke), and long-term rehabilitation.

Stroke is one of the most preventable brain disorders. Many risk factors for stroke are associated with diet and lifestyle, including high blood pressure, obesity, smoking, and inactivity. Medicines (such as blood-pressure medication) and behaviors (such as exercising and avoiding smoking) that address these risk factors help prevent stroke.

Acute treatment focuses on dissolving the blood clot of an ischemic stroke, or stopping the bleeding of a hemorrhagic stroke.

Long-term rehabilitation helps individuals cope with difficulties arising from strokes and their aftermath.

U.S.Government Sites

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