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Skip Navigation LinksHome > Research > Disease Research Areas > Brain and Spinal Cord Injury
Brain and Spinal Cord Injury 
 

 

 Hope Center Scientists and Clinicians who Work on Brain and Spinal Cord Injury

Philip V. Bayly Ph.D.
Hughes Professor of Mechanical Engineering; Professor of Biomedical Engineering

Biomechanical factors in traumatic injury to the brain and spinal cord

David L. Brody M.D., Ph.D.
Assistant Professor of Neurology

Translational research in traumatic brain injury

Valeria Cavalli Ph.D.
Assistant Professor of Anatomy and Neurobiology

Axonal Transport, Injury Signaling and Nerve Regeneration

Aaron DiAntonio M.D., Ph.D.
Associate Professor of Developmental Biology

Mechanisms of synaptic structure and function during development

Mark P. Goldberg M.D.
Professor of Neurology, Neurobiology, and Biomedical Engineering; Director of the Hope Center for Neurological Disorders

Mechanisms of ischemic injury and recovery in white matter axons and glia.

Mark Jacquin Ph.D.
Professor of Neurology

Molecular mechanisms of mammalian sensory system development, plasticity and repair.

Eugene M. Johnson Ph.D.
Professor of Neurology and Developmental Biology; Hope Center Steering Committee

Biological function and pharmacological potential of GFL neurotrophic factors

Jin-Moo Lee M.D., Ph.D.
Associate Professor of Neurology

Understanding the molecular pathogenesis of spontaneous intracerebral hemorrhage

Susan Mackinnon M.D.
Shoenberg Professor, Chief, Division of Plastic and Reconstructive Surgery

Allograft and the Effects of GDNF on Peripheral Nerve Regeneration

Jeffrey D. Milbrandt M.D., Ph.D.
James S. McDonnell Professor and Head of the Department of Genetics, Professor of Neurology; Professor of Pathology & Immunology and Internal Medicine; Hope Center Steering Committee

Axonal degeneration, regulation of myelination, neuronal energetics and mitochondrial function in neuropathy and neurodegenerative disease

Shelly E. Sakiyama-Elbert Ph.D.
Joseph and Florence Farrow Associate Professor of Biomedical Engineering

Tissue and cellular engineering approaches to neurological diseases

Sheng-Kwei (Victor) Song Ph.D.
Associate Professor of Radiology

Development of non-invasive imaging of central nervous system white matter

 Read about Hope Center research on Brain and Spinal Cord Injury

Ribbon diagram of human FKBP12 in complex with sirolimus (rapamycin) [image from Wikipedia Commons]
Nerve Cells
Philip Bayly and Larry Taber 
Larry A. Taber, Ph.D. (left), and Philip Bayly, Ph.D., employ a microindentation device to measure the mechanical properties of embryonic hearts and brains.

Washington University Sites

Information About Brain and Spinal Cord Injury

A traumatic brain injury (TBI) can occur when the head hits an object, or when a blow or penetrating head injury disrupts the brain’s functions. A TBI can cause short or long-term problems with brain function. (Many non-traumatic diseases and conditions can also cause brain injury.)

According to the Brain Injury Association of America, about 1.4 million people suffer a traumatic brain injury each year in the United States, of whom approximately 50,000 die and 1.1 million are treated and released from an emergency room. About 5.3 million Americans have a long-term or lifelong need for help in daily living as a result of traumatic brain injury.

The leading causes of traumatic brain injury are falls, traffic accidents, blows to the head, and assaults. Blasts are a leading cause of TBI for active duty military personnel in war zones. “Shaken baby syndrome” often involves traumatic brain injury resulting from violent shaking, in which babies appear sluggish or non-responsive.

Mild TBI can produce headache, confusion, dizziness, blurred vision, ringing in the ears, bad taste in the mouth, fatigue, a change in sleep patterns, behavioral or mood changes, and trouble with memory, concentration, attention, or thinking. Severe TBI can result in a headache that gets worse or does not go away, vomiting or nausea, convulsions or seizures, an inability to awaken from sleep, dilation of one or both pupils of the eyes, slurred speech, weakness or numbness in the extremities, loss of coordination, and confusion, restlessness, or agitation.
(Adapted from NINDS Brain Injury page)

Traumatic spinal cord injury happens when blows to the spine at any point injure axons—nerves that carry messages between the brain and parts of the body. The extent of after-effects depends on how many axons are damaged, and how seriously. Spinal cord injury effects can range from complete recovery to complete paralysis.

What are the costs of traumatic brain injury?

The Brain Injury Association of America estimates that traumatic brain injury cost the U.S. an estimated $56.3 billion in the United States in 1995 in direct and indirect costs (such as lost productivity).

Traumatic brain injury can cause epilepsy, and can increase the risk for Alzheimer’s disease, Parkinson’s disease, and other brain disorders.

What are some research directions in traumatic brain and spinal cord injury?
Scientists reported in September 2006 that a drug used to treat Alzheimer’s improved memory in victims of TBI.

Improved rehabilitation techniques are improving outcomes for persons with injuries to the brain and spinal cord.

U.S. Government Sites

Associations and Foundations