Posted in the category:

Pilot Projects

Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis

Posted on June 28, 2017

Qingli Xiao, Ping Yan, Xiucui Ma, Haiyan Liu, Ronaldo Perez, Alec Zhu, Ernesto Gonzales, Danielle L. Tripoli, Leah Czerniewski, Andrea Ballabio, John R. Cirrito, Abhinav Diwan and Jin-Moo Lee: 2015 J Neurosci ;35(35):12137-51. Read More

Posted in: HPAN, Lysosome, Neurodegeneration, Neurogenetics & Transcriptomics, Neurovascular Injury & Repair, Pilot Projects, Publications Faculty: , ,

An antidepressant decreases CSF Aβ production in healthy individuals and in transgenic AD mice

Posted on June 28, 2017

Yvette I. Sheline, Tim West, Kevin Yarasheski, Robert Swarm, Mateusz S. Jasielec, Jonathan R. Fisher, Whitney D. Ficker, Ping Yan, Chengjie Xiong, Christine Frederiksen, Monica V. Grzelak, Robert Chott, Randall J. Bateman, John C. Morris, Mark A. Mintun, Jin-Moo Lee and John R. Cirrito: 2014 Sci Transl Med, 10.1126/scitranslmed.3008169 Read More

Posted in: HPAN, Lysosome, Neurodegeneration, Neurogenetics & Transcriptomics, Neurovascular Injury & Repair, Pilot Projects, Publications Faculty: , , ,

Age and Amyloid Effects on Human Central Nervous System Amyloid-Beta Kinetics

Posted on June 28, 2017

Patterson BW, Elbert DL, Mawuenyega KG, Kasten T, Ovod V, Ma S, Xiong C, Chott R, Yarasheski K, Sigurdson W, Zhang L, Goate A, Benzinger T, Morris JC, Holtzman D, Bateman RJ: 2015 ANNALS of Neurology, 10.1002/ana.24454 Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, Neurogenetics, Neurogenetics & Transcriptomics, Pilot Projects, Publications Faculty: , , ,

Myofibrillar disruption and RNA-binding protein aggregation in a mouse model of limb-girdle muscular dystrophy 1D

Posted on June 28, 2017

Rocio Bengoechea Sara K. Pittman Elizabeth P. Tuck Heather L. True Conrad C. Weihl*: 2015 Human Molecular Genetics 24(23):6588-602 *corresponding author Read More

Posted in: HPAN, Neurodegeneration, Pilot Projects, Publications Faculty: ,

Myopathy-causing mutations in an Hsp40 chaperone disrupt interactions with specific client conformers

Posted on June 28, 2017

Kevin C. Stein, Rocio Bengoechea, Matthew B. Harms, Conrad C. Weihl* and Heather L. True*: 2014 Journal of Biological Chemistry. 289(30):21120-21130 *co-corresponding authors. Read More

Posted in: HPAN, Neurodegeneration, Pilot Projects, Publications Faculty: ,