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Simple nutrients bypass the requirement for HLH-30 in coupling lysosomal nutrient sensing to survival

Posted on June 11, 2019

John T. Murphy , Haiyan Liu , Xiucui Ma, Alex Shaver, Brian M. Egan, Clara Oh, Alexander Boyko, Travis Mazer, Samuel Ang, Rohan Khopkar, Ali Javaheri, Sandeep Kumar, Xuntian Jiang, Daniel Ory, Kartik Mani, Scot J. Matkovich, Kerry Kornfeld , Abhinav Diwan. PLoS biology, Volume 17, Issue 5, 1 May 2019, Page e3000245 Read More

Posted in: HPAN, Lysosome, Neurodegeneration, Publications Faculty:

A maternal high-fat, high-sucrose diet induces transgenerational cardiac mitochondrial dysfunction independently of maternal mitochondrial inheritance

Posted on May 28, 2019

Jeremie L. A. Ferey, Anna L. Boudoures, Michaela Reid, Andrea Drury, Suzanne Scheaffer, Zeel Modi, Attila Kovacs, Terri Pietka, Brian J. DeBosch, Michael D. Thompson, Abhinav Diwan, and Kelle H. Moley. American Journal of Physiology – Heart and Circulatory Physiology, Volume 316, Issue 5, May 2019, Pages H1202-H1210 Read More

Posted in: HPAN, Lysosome, Neurodegeneration, Publications Faculty:

TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers

Posted on May 24, 2019

Jorge L. Del-Aguila, Bruno A. Benitez, Zeran Li, Umber Dube, Kathie A. Mihindukulasuriya, John P. Budde, Fabiana H. G. Farias, Maria Victoria Fernández, Laura Ibanez, Shan Jiang, Richard J. Perrin, Nigel J. Cairns, John C. Morris, Oscar Harari and Carlos Cruchaga. Molecular Neurodegeneration, Volume 14, Issue 1, 8 May 2019, Article number 18 Read More

Posted in: HPAN, Lysosome, Neurodegeneration, Neurogenetics & Transcriptomics, Publications Faculty: , , ,

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting

Posted on May 24, 2019

Ganesh Chauhan, Hieab H.H. Adams, Claudia L. Satizabal, […], Jin-Moo Lee, Quenna Wong, Braxton D. Mitchell, Stephen S. Rich, Patrick F. McArdle, Mirjam I. Geerlings, Yolanda van der Graaf, View ORCID ProfilePaul I.W. de Bakker, View ORCID ProfileFolkert W. Asselbergs, Velandai Srikanth, Russell Thomson, Rebekah McWhirter, Chris Moran, Michele Callisaya, Thanh Phan, View ORCID ProfileLoes C.A. Rutten-Jacobs, Steve Bevan, View ORCID ProfileChristophe Tzourio, Karen A. Mather, Perminder S. Sachdev, Cornelia M. van Duijn, Bradford B. Worrall, Martin Dichgans, Steven J. Kittner, Hugh S. Markus, Mohammad A. Ikram, Myriam Fornage, Lenore J. Launer, Sudha Seshadri, W.T. Longstreth, Stéphanie Debette. Neurology, Volume 92, Issue 5, 29 January 2019, Pages E486-E503
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Posted in: HPAN, Lysosome, Neurodegeneration, Neurogenetics, Neurovascular Injury & Repair, Publications Faculty:

The role of membrane excitability in pancreatic β-cell glucotoxicity

Posted on May 21, 2019

Zeenat A. Shyr, Zhiyu Wang, Nathaniel W. York, Colin G. Nichols & Maria S. Remedi. Scientific Reports, Volume 9, Issue 1, 1 December 2019, Article number 6952 Read More

Posted in: Lysosome, Neurogenetics & Transcriptomics, NeuroRestorative Therapy, Neurovascular Injury & Repair, Publications Faculty: ,