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Engineered protein disaggregases mitigate toxicity of aberrant prion-like fusion proteins underlying sarcoma

Posted on October 14, 2019

Jeremy J. Ryan, Macy L. Sprunger, Kayla Holthaus, James Shorter and Meredith E. Jackrel. Journal of Biological Chemistry, Volume 294, Issue 29, 2019, Pages 11286-11296 Read More

Posted in: HPAN, Neurodegeneration, Publications Faculty:

Genetic ablation of acid ceramidase in Krabbe disease confirms the psychosine hypothesis and identifies a new therapeutic target

Posted on October 14, 2019

Yedda Li, Yue Xu, Bruno A. Benitez, Murtaza S. Nagree, Joshua T. Dearborn, Xuntian Jiang, Miguel A. Guzman, Josh C. Woloszynek, Alex Giaramita, Bryan K. Yip, Joseph Elsbernd, Michael C. Babcock, Melanie Lo, Stephen C. Fowler, David F. Wozniak, Carole A. Vogler, Jeffrey A. Medin, Brett E. Crawford, and Mark S. Sands. Proceedings of the National Academy of Sciences of the United States of America, Volume 116, Issue 40, 1 October 2019, Pages 20097-20103 Read More

Posted in: HPAN, Lysosome, Neurodegeneration, Publications Faculty:

Feasibility of fast brain diffusion MRI to quantify white matter injury in pediatric hydrocephalus

Posted on October 11, 2019

Albert M. Isaacs , Joshua S. Shimony, Diego M. Morales, Leandro Castaneyra-Ruiz, Alexis Hartman, Madison Cook, Christopher D. Smyser, Jennifer Strahle, Matthew D. Smyth, Yan Yan, James P. McAllister II, Robert C. McKinstry and David D. Limbrick Jr. Journal of Neurosurgery: Pediatrics, Volume 24, Issue 4, October 2019, Pages 461-468 Read More

Posted in: Axon Injury & Repair, HPAN, Neurodegeneration, Neurogenetics & Transcriptomics, NeuroRestorative Therapy, Neurovascular Injury & Repair, Publications Faculty: , ,

Targeting immune cells may be potential therapy for Alzheimer’s

Posted on October 10, 2019

Mouse study shows immune cells drive brain damage Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, News Faculty:

Leading the way for personalized medicine

Posted on October 9, 2019

Pioneering individualized treatment approaches in obesity, diabetes, breast cancer and Alzheimer’s disease Read More

Posted in: Axon Injury & Repair, Clocks & Sleep, HPAN, Lysosome, Neurodegeneration, Neurogenetics & Transcriptomics, News Faculty: , , , ,