yoo

Andrew Yoo, PhD

Assistant Professor of Developmental Biology

MicroRNA-mediated neuronal reprogramming and chromatin remodeling Read More

Email: yooa@wustl.edu
Lab Phone: (314) 362-1814
Website: Yoo Lab
Lab Location: Cancer Research Bldg 3600
Keywords: tissue culture modeling of neurological diseases, neurogenic activities of microRNAs, neuronal reprogramming and generation of human neurons, chromatin remodeling during fate conversion

MicroRNA-mediated neuronal reprogramming and chromatin remodeling

Human skin fibroblasts directly converted to neurons (green: TUBB3, blue: DAPI)

 

We are interested in molecular mechanisms governing the acquisition of neuronal cell fate and reprogramming of non-neuronal cells into neurons.  Our work previously showed that a set of brain-enriched microRNAs (miR-9/9* and miR-124) promote the assembly of neuron-specific chromatin remodeling complexes during neural development, and demonstrated that expressing these microRNAs ectopically in non-neuronal cell types could convert their cell fates directly into neurons.  We are currently devising experimental protocols to generate specific neuronal subtypes from human skin cells, with an ultimate goal of developing tissue culture models of neurological diseases.  Furthermore, we investigate the molecular mechanisms underlying the neurogenic activities of microRNAs specifically focusing on how microRNAs alter chromatin states.

Updated February 2014

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