bieschke (150x150)

Jan Bieschke, PhD

Assistant Professor of Biomedical Engineering

Mechanisms and therapeutic strategies in age-related protein misfolding Read More

Email: bieschke@wustl.edu
Lab Phone: (314) 935-7038
Website: Bieschke Lab
Lab Location: 2033 Brauer Hall
Keywords: protein misfolding, Alzheimer, Parkinson, mechanism, Egcg

Mechanisms and therapeutic strategies in age-related protein misfolding

Professor Bieschke’s research focuses on the processes of protein folding and misfolding and how these processes can lead to widespread aging-related diseases such as Alzheimer’s and Parkinson’s disease. Self-assembly of proteins seems to be a generic process but results in insoluble fibrillar structures that can be toxic to the cell but can also have unique material properties. Professor Bieschke aims to dissect and influence these self-assembly processes using biophysical tools such as single molecule fluorescence, atomic force microscopy and sub-diffraction microscopy, in order to develop new strategies to counteract protein misfolding diseases.


Updated January 2014

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