Jeff Gidday, PhD
Associate Professor of Neurosurgery
Identifying endogenous epigenetic mechanisms of neurovascular protection in acute and chronic disease Read More
|Lab Phone:||(314) 286-2795|
|Lab Location:||McDonnell Pediatric Research Building 3rd Floor|
|Keywords:||stroke, glaucoma, whole animal models, molecular biology, immunocytochemistry, epigenetics|
Adaptive Epigenetics as a Therapeutic Strategy for Stroke and Glaucoma
Research in our laboratory is aimed at identifying the stimuli capable of inducing epigenetic responses that promote long-lasting increases in resistance to neurovascular injury/death in acute (stroke) and chronic (glaucoma) CNS disease models, as well as the molecular and genetic bases of these responses. Recent findings that the duration of the injury-tolerant phenotype for acute retinal and cerebral ischemia could be extended by repetitive preconditioning provide a platform for extending the concept of adaptive epigenetics as a therapeutic strategy for chronic neurodegenerative disease. The translational potential of this approach is strengthened further by our finding in glaucoma that repetitive conditioning after disease onset is also neuroprotective.
Updated January 2014
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