cairns_nigel

Nigel Cairns, PhD, FRCPath

Research Professor of Neurology

Protein misfolding, inclusion formation and neurodegeneration in Frontotemperal Dementias Read More

Email: cairns@wustl.edu
Lab Phone: (314) 362-7420
Website: Cairns Lab
Lab Location: McMillan 313
Keywords: Alzheimer's disease, Frontotemporal lobar degeneration, histology, immunohistochemistry, protein chemistry, transgenic mouse model

Protein misfolding, inclusion formation and neurodegeneration in Frontotemperal Dementias

Acknowledgment: P30 NS057105

The frontal and temporal lobes of the brain degenerate to cause severely debilitating disease in a group of disorders called frontotemporal dementias. These diseases are both clinically and pathologically heterogeneous and although genetic causes have been identified in some rare familial cases, the causes and pathogenesis of these diseases remain largely unknown. Nigel Cairns is interested in clarifying the pathological changes in the brains of these patients who come to autopsy and the mechanisms by which nerve cells die and cause dementia. His multidisciplinary approach uses histological, biochemical, and cell biological experiments to determine the role of candidate pathological proteins in frontotemporal dementias. These experiments will throw new light on the pathogenesis of this enigmatic group of diseases and generate novel avenues for therapeutic intervention.


Updated January 2014

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