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Qin Yang, MD, PhD

Associate Professor of Radiation Oncology

Understand neural cell reprogramming/regeneration and generate “safe” neural cells for neurological disorder treatment Read More

Email: qyang@wustl.edu
Lab Phone: (314) 747-5445
Website: http://radonc.wustl.edu/cancerbiology/yang.html
Lab Location: 4511 Forest Park, Suite 3101A
Keywords: neural regeneration, neuron conversion, oligodendrocyte myelination, telomeres, protein kinase inhibitor, molecular signaling

Understand neural cell reprogramming/regeneration and generate “safe” neural cells for neurological disorder treatment

The long-term goal of this research is to develop transgene-free reprogramming cell technology to efficiently generate “safe” neural cells. Our results showed that the regulation of cellular senescence is a crucial step for fibroblast-neural cell conversion. Genetic manipulations of the cellular senescence pathways efficiently induced conversion of human fibroblasts into functional neurons. Furthermore, we screened a kinase inhibitor library and found that the kinase inhibitors converted fibroblasts into functional neurons and oligodendrocytes. Mechanistically, the inhibitors prevented cellular senescence, leading to fibroblast-neural cell conversion. We will investigate the mechanism of neural reprogramming and develop a novel therapy for neurological disorders. We will also investigate the role of telomere maintenance in neurons.

Updated February 2014

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