Qin Yang, MD, PhD
Associate Professor of Radiation Oncology
Understand neural cell reprogramming/regeneration and generate “safe” neural cells for neurological disorder treatment Read More
|Lab Phone:||(314) 747-5445|
|Lab Location:||4511 Forest Park, Suite 3101A|
|Keywords:||neural regeneration, neuron conversion, oligodendrocyte myelination, telomeres, protein kinase inhibitor, molecular signaling|
Understand neural cell reprogramming/regeneration and generate “safe” neural cells for neurological disorder treatment
The long-term goal of this research is to develop transgene-free reprogramming cell technology to efficiently generate “safe” neural cells. Our results showed that the regulation of cellular senescence is a crucial step for fibroblast-neural cell conversion. Genetic manipulations of the cellular senescence pathways efficiently induced conversion of human fibroblasts into functional neurons. Furthermore, we screened a kinase inhibitor library and found that the kinase inhibitors converted fibroblasts into functional neurons and oligodendrocytes. Mechanistically, the inhibitors prevented cellular senescence, leading to fibroblast-neural cell conversion. We will investigate the mechanism of neural reprogramming and develop a novel therapy for neurological disorders. We will also investigate the role of telomere maintenance in neurons.
Updated February 2014
Hope Center Affiliations
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