UnLINcing the nuclear envelope: towards an understanding of the physiological significance of nuclear positioning

Razafsky, D., Zang, S., Hodzic, D.; Biochem. Soc. Trans., 39:1790-1794 (2011). Read More


Appropriate tissue morphogenesis strictly requires the developmental regulation of different types of nuclearmovements. LINC (linker of nucleoskeleton and cytoskeleton) complexes are macromolecular scaffolds thatspan the nuclear envelope and physically connect the nuclear interior to different cytoskeletal elements andmolecular motors, thereby playing essential roles in nucleokinesis. Recent studies dedicated to the in vivodisruption of LINC complexes not only confirmed their widespread role in nuclear dynamics, but also led toa vigorous regain of interest in the physiological relevance of nuclear positioning within cells and syncitia.In the present paper, we review the results of LINC complex disruption in vivo across different organismsand the potential implications of observed phenotypes in human diseases.

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Posted on February 12, 2014
Posted in: HPAN, Neurodegeneration, Neurogenetics, Publications Authors: