Voluntary exercise training: Analysis of mice in uninjured, inflammatory, and nerve-injured pain states

Sheahan TD, Copits BA, Golden JP, Gereau RW: 2015 PLoS One, 10(7), doi: 10.1371/journal.pone.0133191 Read More


Both clinical and animal studies suggest that exercise may be an effective way to manageinflammatory and neuropathic pain conditions. However, existing animal studies commonly use forced exercise paradigms that incorporate varying degrees of stress, which itself can elicit analgesia, and thus may complicate the interpretation of the effects of exercise on pain. We investigated the analgesic potential of voluntary wheel running in the formalin model of acuteinflammatory pain and the spared nerve injury model of neuropathic pain in mice. In uninjured, adult C57BL/6J mice, 1 to 4 weeks of exercise training did not alter nociceptive thresholds, lumbar dorsal root ganglia neuronal excitability, or hindpaw intraepidermal innervation. Further, exercisetraining failed to attenuate formalin-induced spontaneous pain. Lastly, 2 weeks of exercise trainingwas ineffective in reversing spared nerve injury-induced mechanical hypersensitivity or in improving muscle wasting or hindpaw denervation. These findings indicate that in contrast to rodent forcedexercise paradigms, short durations of voluntary wheel running do not improve pain-like symptoms in mouse models of acute inflammation and peripheral nerve injury.

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Posted on September 25, 2015
Posted in: Axon Injury & Repair, Publications Authors: