Empirical comparison of diffusion kurtosis imaging and diffusion basis spectrum imaging using the same acquisition in healthy young adults

Sijia Wang, Daniel J. Peterson, Yong Wang, Qing Wang, Thomas J. Grabowski, Wenbin Li and Tara M. Madhyastha: 2017 Frontiers in Neurology Vol. 8 MAR, Art.#118 Read More


As diffusion tensor imaging gains widespread use, many researchers have been motivated to go beyond the tensor model and fit more complex diffusion models, to gain a more complete description of white matter microstructure and associated pathology. Two such models are diffusion kurtosis imaging (DKI) and diffusion basis spectrum imaging (DBSI). It is not clear which DKI parameters are most closely related to DBSI parameters,so in the interest of enabling comparisons between DKI and DBSI studies, we conducted an empirical survey of the interrelation of these models in 12 healthy volunteers using the same diffusion acquisition. We found that mean kurtosis is positively associated with the DBSI fiber ratio and negatively associated with the hindered ratio. This was primarily driven by the radial component of kurtosis. The axial component of kurtosis was strongly and specifically correlated with the restricted ratio. The joint spatial distributions of DBSI and DKI parameters are tissue-dependent and stable across healthy individuals. Our contribution is a better understanding of the biological interpretability of the parameters generated by the two models in healthy individuals. © 2017 Wang, Peterson, Wang, Wang, Grabowski, Li and Madhyastha.

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Posted on May 11, 2017
Posted in: Axon Injury & Repair, HPAN, Neurodegeneration, Publications Authors: