Quantitative hemodynamic PET imaging using image-derived arterial input function and a PET/MR hybrid scanner

Yi Su, Andrei G Vlassenko, Lars E Couture, Tammie LS Benzinger, Abraham Z Snyder, Colin P Derdeyn, Marcus E Raichle: 2017 Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume 37, Issue 4, Pages 1435-1446 Read More


Positron emission tomography (PET) with 15O-tracers is commonly used to measure brain hemodynamic parameters such as cerebral blood flow, cerebral blood volume, and cerebral metabolic rate of oxygen. Conventionally, the absolute quantification of these parameters requires an arterial input function that is obtained invasively by sampling blood from an artery. In this work, we developed and validated an image-derived arterial input function technique that avoids the unreliable and burdensome arterial sampling procedure for full quantitative 15O-PET imaging. We then compared hemodynamic PET imaging performed on a PET/MR hybrid scanner against a conventional PET only scanner. We demonstrated the proposed imaging-based technique was able to generate brain hemodynamic parameter measurements in strong agreement with the traditional arterial sampling based approach. We also demonstrated that quantitative 15O-PET imaging can be successfully implemented on a PET/MR hybrid scanner.

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Posted on August 17, 2017
Posted in: HPAN, Neurodegeneration, Publications Authors: ,