Uncovering molecular grammar

Collaborative team deciphers the protein sequence-encoded mechanism that drives phase separation Read More

From the WashU School of Engineering & Applied Science News

An international research collaboration including engineers from Washington University in St. Louis have discovered a protein sequence mechanism that triggers phase separation deep within a single cell.

Their findings, published in Cell, could provide insights into age-related diseases such as amyotrophic lateral sclerosis and some cancers.

The team–comprised of scientists from the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) in Dresden and Washington University, including Rohit Pappu, the Edwin H. Murthy Professor of Engineering at WashU’s School of Engineering & Applied Science and postdoctoral students Alex Holehouse and Jeong-Mo Choi — developed a combination of experimental and theoretical analysis to uncover a protein sequence that underlies phase separation of prion-like RNA binding proteins.

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Posted on July 9, 2018
Posted in: HPAN, Neurodegeneration, News Authors: