Gpr126/Adgrg6 has Schwann cell autonomous and nonautonomous functions in peripheral nerve injury and repair

Amit Mogha, Breanne L. Harty, Dan Carlin, Jessica Joseph, Nicholas E. Sanchez, Ueli Suter, Xianhua Piao, Valeria Cavalli and Kelly R. Monk. Journal of Neuroscience, Volume 36, Issue 49, 7 December 2016, Pages 12351-12367 Read More

Abstract

Schwann cells (SCs) are essential for proper peripheral nerve development and repair, although the mechanisms regulating these processes are incompletely understood. We previously showed that the adhesion G protein-coupled receptor Gpr126/Adgrg6 is essential for SC development and myelination. Interestingly, the expression of Gpr126 is maintained in adult SCs, suggestive of a function in the mature nerve. We therefore investigated the role of Gpr126 in nerve repair by studying an inducible SC-specific Gpr126 knock-out mouse model. Here, we show that remyelination is severely delayed after nerve-crush injury. Moreover, we also observe non cell-autonomous defects in macrophage recruitment and axon regeneration in injured nerves following loss of Gpr126 in SCs. This work demonstrates that Gpr126 has critical SC-autonomous and SC-nonautonomous functions in remyelination and peripheral nerve repair. © 2016 the authors.

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Posted on December 16, 2016
Posted in: Axon Injury & Repair, Publications Authors: