Ultrasound Hyperthermia Technology for Radiosensitization

Lifei Zhu, Michael B. Altman, Andrei Laszlo, William Straube, Imran Zoberi, Dennis E. Hallahan, HongChen. Ultrasound in Medicine and Biology 2019 Read More


Hyperthermia therapy (HT) raises tissue temperature to 40–45°C for up to 60 min. Hyperthermia is one of the most potent sensitizers of radiation therapy (RT). Ultrasound-mediated HT for radiosensitization has been used clinically since the 1960s. Recently, magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU), which has been approved by the United States Food and Drug Administration for thermal ablation therapy, has been adapted for HT. With emerging clinical trials using MRgHIFU HT for radiosensitization, there is a pressing need to review the ultrasound HT technology. The objective of this review is to overview existing HT technology, summarize available ultrasound HT devices, evaluate clinical studies combining ultrasound HT with RT and discuss challenges and future directions. © 2018 World Federation for Ultrasound in Medicine & Biology

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Posted on February 26, 2019
Posted in: HPAN, Neurodegeneration, Neurogenetics & Transcriptomics, NeuroRestorative Therapy, Neurovascular Injury & Repair, Publications Authors: ,