A DLK-dependent axon self-destruction program promotes Wallerian degeneration

Miller BR, Press C, Daniels RW, Sasaki Y, Milbrandt J, DiAntonio A (2009). Nature Neuroscience, 12:387-389 Read More


Axon degeneration underlies many common neurological disorders, but the signaling pathways that orchestrate axon degeneration are unknown. We found that dual leucine kinase (DLK) [corrected to add (DLK) abbreviation] promoted degeneration of severed axons in Drosophila and mice, and that its target, c-Jun N-terminal kinase, promoted degeneration locally in axons as they committed to degenerate. This pathway also promoted degeneration after chemotherapy exposure and may be a component of a general axon self-destruction program.

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Posted on October 7, 2009
Posted in: Axon Injury & Repair, Pilot Projects, Publications Authors: ,