Erythrocytes: oxygen sensors and modulators of vascular tone

Ellsworth ML, Ellis CG, Goldman D, Stephenson AH, Dietrich HH, Sprague RS (2009). Physiology (Bethesda), 24:107-16. PMID:19364913 Read More


Through oxygen-dependent release of the vasodilator ATP, the mobile erythrocyte plays a fundamental role in matching microvascular oxygen supply with local tissue oxygen demand. Signal transduction within the erythrocyte and microvessels as well as feedback mechanisms controlling ATP release have been described. Our understanding of the impact of this novel control mechanism will rely on the integration of in vivo experiments and computational models.

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Posted on October 7, 2009
Posted in: HPAN, Neurodegeneration, Publications Authors: