Autosomal-dominant Alzheimer’s disease: a review and proposal for the prevention of Alzheimer’s disease

Bateman RJ, Aisen PS, De Strooper B, Fox NC, Lemere CA, Ringman JM, Salloway S, Sperling RA, Windisch M, Xiong C (2011). Alzheimers Res Ther, 2(6):35. PMCID:PMC3109410 Read More

Abstract

Autosomal-dominant Alzheimer’s disease has provided significant understanding of the pathophysiology of Alzheimer’s disease. The present review summarizes clinical, pathological, imaging, biochemical, and molecular studies of autosomal-dominant Alzheimer’s disease, highlighting the similarities and differences between the dominantly inherited form of Alzheimer’s disease and the more common sporadic form of Alzheimer’s disease. Current developments in autosomal-dominant Alzheimer’s disease are presented, including the international Dominantly Inherited Alzheimer Network and this network’s initiative for clinical trials. Clinical trials in autosomal-dominant Alzheimer’s disease may test the amyloid hypothesis, determine the timing of treatment, and lead the way to Alzheimer’s disease prevention.

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Posted on October 10, 2011
Posted in: HPAN, Neurodegeneration, Neurogenetics, Publications, Therapeutics & Diagnostics Authors: