Iatrogenic botulism due to therapeutic botulinum toxin a injection in a pediatric patient

Crowner BE, Brunstrom JE, Racette BA (2007). Clin Neuropharmacol, 30(5):310-3
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Botulinum toxin A is commonly used to reduce spasticity and dystonia in children with cerebral palsy. We report a pediatric patient who developed systemic botulism as a result of a severe overdose of the injected toxin (40 U/kg). This case highlights the importance of physicians having adequate knowledge of primate and human literature on the lethal dose, 50% of botulinum toxin A before injecting children.

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Posted on October 14, 2007
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