Rat brains also have a default mode network

Lu H, Zou Q, Gu H, Raichle ME, Stein EA, Yang Y (2012). Proc Natl Acad Sci USA, 109(10):3979-84 Read More


The default mode network (DMN) in humans has been suggested to support a variety of cognitive functions and has been implicated in an array of neuropsychological disorders. However, its function(s) remains poorly understood. We show that rats possess a DMN that is broadly similar to the DMNs of nonhuman primates and humans. Our data suggest that, despite the distinct evolutionary paths between rodent and primate brain, a well-organized, intrinsically coherent DMN appears to be a fundamental feature in the mammalian brain whose primary functions might be to integrate multimodal sensory and affective information to guide behavior in anticipation of changing environmental contingencies.

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Posted on March 19, 2012
Posted in: Neurodegeneration, Publications Authors: