Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding HP, Ron D (2000). Science, 287(5453):664-6 Read More

Abstract

Malfolded proteins in the endoplasmic reticulum (ER) induce cellular stress and activate c-Jun amino-terminal kinases (JNKs or SAPKs). Mammalian homologs of yeast IRE1, which activate chaperone genes in response to ER stress, also activated JNK, and IRE1alpha-/- fibroblasts were impaired in JNK activation by ER stress. The cytoplasmic part of IRE1 bound TRAF2, an adaptor protein that couples plasma membrane receptors to JNK activation. Dominant-negative TRAF2 inhibited activation of JNK by IRE1. Activation of JNK by endogenous signals initiated in the ER proceeds by a pathway similar to that initiated by cell surface receptors in response to extracellular signals.

 

Full Text

EmailPrintShare
Posted on October 10, 2000
Posted in: HPAN, Publications Authors: