2014 Hope Center Retreat

April 15, 2014: Danforth Plant Science Center Read More

Program, 2014 Retreat

Welcome and Opening Remarks Celeste Karch & Carlos Cruchaga

State of the Hope Center Alison Goate, Director

Session 1: Axon Injury & Repair (Chair: Valeria Cavalli (Anatomy and Neurobiology))

  • Matthew MacEwan (Ray Lab, Neurological Surgery)
    “Neuroregenerative electrodes enable functional electrical stimulation of peripheral motor axons and distal musculature”
  • Geraldine Kress (Mennerick Lab, Psychiatry)
    “Temporally distinct monosynaptic and disynaptic components of dopamine release”
  • Vera Valakh (DiAntonio Lab, Developmental Biology)
    “Cytoskeletal destabilization activates the DLK pathway to regulate synapse development and axonal regrowth”

Session 2: Neurovascular Injury & Repair (Chair: Jin-Moo Lee (Neurology))

  • Kathrin Andrich (Bieschke Lab, Biomedical Engineering)
    “Aggregation in Systemic light chain amyloidosis (AL amyloidosis)”
  • Eric Milner (Zipfel Lab, Neurological Surgery)
    “Post-conditioning reduces subarachnoid hemorrhage–inducedneurovascular dysfunction via HIF-1”
  • Andrei Vlassenko (Radiology)
    “Aerobic glycolysis in brain tumors”

Hope Center Lecture: Alfred W. Sandrock Jr (Biogen Idec)
”Innovation in Multiple Sclerosis: Past and Present ”

Session 3: Neurodegeneration (Chair: Chris Weihl (Neurology))

  • Matheus Victor (Yoo Lab, Developmental Biology)
    “Guided conversion of human fibroblasts to striatal neurons”
  • Kristen Funk (Diamond Lab, Neurology)
    “Modulation of pathogenic tau fibrils into microglia by antibodiesand heparin mimetics”
  • Shannon Macauley-Rambach (Holtzman Lab, Neurology)
    “Investigating the mechanistic link between diabetes and Alzheimer’sdisease: the effects of hyperglycemia on neuronal activity andAmyloid beta levels within the brain’s interstitial fluid”
  • Claudia Cantoni (Piccio Lab, Neurology)
    “Role of miR-223 in multiple sclerosis and its animal model”

Session 4: Neurogenetics (Chair: Matt Harms (Neurology))

  • Sarah DeGenova (Monk Lab, Developmental Biology)
    “The adhesion-GPCR Gpr56 regulates glial cell development andmyelination”
  • Maria Praggastis (Ory Lab, Medicine)
    “A murine Niemann-Pick C1 (NPC1) I1061T knockin modelrecapitulates the pathological features of the most prevalent humandisease allele”
  • Janet Cady (Harms Lab, Neurology)
    “TREM2 variant p.R47H as a risk factor for sporadic amyotrophiclateral sclerosis”

Poster session