Lysosome Processing & Transport

Organizer: Celeste Karch Read More


The Lysosome Processing & Transport Group is a group of investigators whose research goals range from basic lysosomal system biology to therapy in model organisms and humans. The focus of this group is to introduce key research developments and current innovative studies in the lysosome field.  Members of this group share an interest in the autophagy/lysosomal pathway (ALP) and its relationship to neurodegenerative disorders, development of novel therapeutic strategies of Lysosome storage diseases and the use of cell and animal models as tools to determine the role of the ALP in the pathogenesis of neurological and cardiovascular diseases.  Group meetings are open to the Washington University community, and those outside also are welcome to present their work and exchange new data and cutting-edge ideas.

Organizers/Contact Information

For additional information about the Lysosome Processing & Transport Group, please contact the faculty organizer, Celeste Karch, or our administrative coordinator, Kally Coleman.

2021/2022 Schedule, Lysosome Processing & Transport Group

3rd Thursday of the month
Zoom conference

For virtual meeting information email Celeste Karch.

Zoom information (WUSTL Key required)

  • August 19: Mark Cookson (National Institute on Aging/NIH) “Lysosomal activation of Leucine-Rich Repeat Kinase 2 in the molecular pathogenesis of Parkinson’s disease”
  • September 16: Allen Seylani (National Heart, Lung, and Blood Institute/NIH) “Novel Regulatory Function of GCN5L1 In Lysosomal Biology – A potential Therapeutic Target In Neurodegenerative Diseases”
  • October 21: Peter Lobel (Rutgers University) “From basic research on lysosomal targeting to disease discovery and drug development”
  • November 18: Joshua Shulman (Baylor College of Medicine) “Functional Genomics of the Lysosome in Parkinson’s Disease”
  • Postponed – December 16: Michael Ward (NINDS/NIH) “Proteins on tap – Lysosomal regulation of axonal RNA transport and local translation”
  • January 20: Andy Nguyen (Saint Louis University) “ASO-based therapeutic approach for progranulin-deficient frontotemporal dementia”
  • February 17: Emily Mangano Rocha (University of Pittsburgh) “Characterizing the link between LRRK2 and lysosomal dysfunction in Parkinson’s disease” 
  • March 17: Adamantios Mamais (University of Florida) “Dysregulation of iron homeostasis downstream of LRRK2 signaling”
  • April 21: Malú Gámez Tansey (University of Florida) “LRRK’ing around at the lysosome: Assessing the effects of LRRK2 and other PD-risk genes on lysosomal function in peripheral immune cells”
  • CANCELLED – May 19
  • June 16: Michael Ward (NINDS/NIH) “Proteins on tap – Lysosomal regulation of axonal RNA transport and local translation”

All meetings are listed on the Office of Neuroscience Research (ONR) Calendar.

Archive of Previous Seasons







Lysosome Processing & Transport Faculty Members

Faculty organizer: Celeste Karch (WashU Psychiatry)

Affiliated faculty members

Bruno Benitez (WashU Psychiatry)
Jonathan Cooper (WashU Pediatrics)
Carlos Cruchaga (WashU Psychiatry)
Patricia Dickson (WashU Pediatrics)
Abhinav Diwan (WashU Medicine)
Timothy Holy (WashU Neuroscience)
Celeste Karch (WashU Psychiatry)
Jonathan Kipnis (WashU Pathology & Immunology)
Stuart Kornfeld (WashU Medicine)
Jin-Moo Lee (WashU Neurology)
Adriana Montaño (Saint Louis University)
Andrew Nguyen (Saint Louis University)
Daniel Ory (WashU Medicine)
Maria Remedi (WashU Medicine)
Rajan Sah (WashU Medicine)
Mark Sands (WashU Medicine)
Gary Silverman (WashU Pediatrics)
Amber Stratman (WashU Cell Biology & Physiology)