Past Pilot Projects

Click “Pilot Project Details” for descriptions and progress. Read More

DNAJB6 in protein aggregation: Integration of clinical material, mouse models and yeast genetics

2011 Award
Principal Investigator: Conrad Weihl, MD, PhD (WUSTL Neurology)
Co-investigators: Heather True-Krob, PhD (WUSTL Cell Biology & Physiology), Matt Harms, MD (WUSTL Neurology)

Pilot Project Details

Quantitation of Amyloid-β peptides in CSF of Alzheimer’s disease participants by immunoprecipitation/mass spectrometry (IP/MS) and solid phase extraction/mass spectrometry (SPE/MS)

2011 Award
Principal Investigators: Randall Bateman, MD and Anne Fagan, PhD (WUSTL Neurology)

Pilot Project Details

Isolating Cell-Type Specific miRNAs from Mice

2011 Award
Principal Investigator: Timothy Miller, MD, PhD (WUSTL Neurology)
Co-investigator: Joseph Dougherty, PhD (WUSTL Genetics)

Pilot Project Details

Noninvasive white matter histology of living EAE mice

2011 Award
Investigator: Victor Song, PhD (WUSTL Radiology)
Co-investigator: Anne Cross, MD (WUSTL Neurology)

Pilot Project Details

Citalopram Decreases Aβ Plaque Accumulation in APP Mice and CSF Aβ in Humans

2010 Award
Principal Investigator: Yvette Sheline, MD (WUSTL Psychiatry)
Co-investigators: Jin-Moo Lee, MD, PhD (WUSTL Neurology), Robert Swarm, MD (WUSTL Anesthesiology)

Pilot Project Details

Identification and functional characterization of the genetic variant causing Kufs’ disease with early dementia in a family with an autosomal dominant inheritance

2010 Award
Principal Investigator: Carlos Cruchaga, PhD (WUSTL Psychiatry)
Co-investigator: Mark Sands, PhD (WUSTL Internal Medicine)

Pilot Project Details

Cis-regulatory mapping of dominant human retinal neurodegenerative disorders

2010 Award
Principal Investigator: Joseph Corbo, MD, PhD (WUSTL Pathology & Immunology)
Co-investigators: Rob Mitra, PhD (WUSTL Genetics), Frans Cremers, PhD (Nijmegen Medical Centre, The Netherlands)

Pilot Project Details

Mechanism of Huntingtin Aggregation Regulated by Profilin

2010 Award
Principal Investigator: Rohit Pappu, PhD (WUSTL Biomedical Engineering)
Co-investigator: Marc Diamond, MD (WUSTL Neurology)

Pilot Project Details

PET tracers for cerebrovascular-specific amyloid imaging

2009 Award
Principal Investigator: Gregory Zipfel, MD (WUSTL Neurosurgery)
Co-investigators: Robert Mach, PhD (WUSTL Radiology), Byung Hee Han, PhD (WUSTL Neurosurgery)

Pilot Project Details

Generating Amyloid Seeds in Lysosomes

2009 Award
Principal Investigator: Carl Frieden, PhD (WUSTL Biochemistry)
Co-investigators: Marc Diamond, MD (WUSTL Neurology, Jin-Moo Lee, MD, PhD (WUSTL Neurology)

Pilot Project Details

Understanding How the Liver Successfully Handles Misfolded SOD1

2009 Award
Principal Investigator: Timothy Miller, MD, PhD (WUSTL Neurology)
Co-investigator: Chris Weihl, MD, PhD (WUSTL Neurology)

Pilot Project Details

Inhibition of the DLK/JNK Pathway as a Therapeutic Target for Axonopathy

2008 Award
Principal Investigator: Aaron DiAntonio, MD, PhD (WUSTL Developmental Biology)
Co-investigator: Jeffrey Milbrandt, MD, PhD (WUSTL Genetics)

Pilot Project Details

Functional RNAi screen to identify pathways essential for protein aggregate clearance and degradation

2008 Award
Principal Investigator: Conrad Weihl, MD, PhD (WUSTL Neurology)
Co-investigator: David Piwnica-Worms, MD, PhD (WUSTL Radiology)

Pilot Project Details

Misfolded protein accumulation and neurodegeneration due to phospholipase gene mutations

2007 Award
Principal Investigator: Paul Kotzbauer, MD, PhD (WUSTL Neurology)
Co-investigator: Joy Snider, MD, PhD (WUSTL Neurology)

Pilot Project Details

Function of FGF14 in progressive spinocerebellar ataxia

2007 Award
Principal Investigator: David Ornitz, MD, PhD (WUSTL Developmental Biology)
Co-investigators: Kel Yamada, MD (WUSTL Neurology), Jeanne Nerbonne, PhD (WUSTL Developmental Biology), David Wozniak, PhD (WUSTL Psychiatry)

Pilot Project Details

Microdevice development for the study of axon degeneration and injury

2007 Award
Principal Investigator: Shelly Sakiyama-Elbert, PhD (WUSTL Biomedical Engineering)
Co-investigators: Karen O’Malley, PhD (WUSTL Anatomy & Neurobiology), Amy Shen, PhD (WUSTL Mechanical Engineering)

Pilot Project Details

Development of a Clinically Relevant Model of Infant Traumatic Brain Injury

2007 Award
Principal Investigator: David Brody, MD, PhD (WUSTL Neurology)
Co-investigators: Alexander Parsadanian, PhD (WUSTL Neurology), Philip Bayly, PhD (WUSTL Mechanical Engineering), Krikor Dikranian, MD, PhD (WUSTL Anatomy & Neurobiology)

Pilot Project Details

Unraveling the amyloid fibril with polyphenols

2006 Award
Principal Investigator: Jin-Moo Lee, MD, PhD (WUSTL Neurology)
Co-investigators: Carl Frieden, PhD (WUSTL Biochemistry), John Heuser, MD (WUSTL Cell Biology & Physiology), Rohit Pappu, PhD (WUSTL Biomedical Engineering), David Wozniak, PhD (WUSTL Psychiatry)

Pilot Project Details

In vivo labeled proteomics in human CSF

2006 Award
Principal Investigator: Randall Bateman, MD (WUSTL Neurology)
Co-investigators: Donald Elbert, PhD (WUSTL Biomedical Engineering), Alison Goate, DPhil (WUSTL Psychiatry)

Pilot Project Details

Use of hybrid mammalian-yeast prions to identify factors that inhibit protein aggregation (2006)

2006 Award
Principal Investigator: David Harris, MD, PhD (WUSTL Cell Biology & Physiology)
Co-investigator: Heather True-Krob, PhD (WUSTL Cell Biology & Physiology)

Pilot Project Details

Genetics of Amyotrophic Lateral Sclerosis

2005 Award
Principal Investigator: Alison Goate, DPhil (WUSTL Psychiatry)

Inhibitors of Sodium Channels as Axonal Protectants in Experimental Autoimmune Encephalomyelitis

2005 Award
Principal Investigator: Anne Cross, MD (WUSTL Neurology)

Stimulating Axonal Protection in ALS via Activation of Nuclear NAD Biosynthesis

2005 Award
Principal Investigators: Jeffrey Milbrandt, MD, PhD (WUSTL Genetics), Anneliese Schaefer, JD, PhD (WUSTL Neurology)

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Active Pilot Projects

Hope Center Pilot awards are two-year projects.  Click below to learn about active pilot projects.

Active pilot projects