Reprogramming rod photoreceptors to treat retinal degeneration
2018 Award
Principal Investigator: Joseph Corbo (WashU Pathology & Immunology)
Collaborator: Vladimir Kefalov (WashU Ophthalmology & Visual Sciences)
Developing Biomarkers for chemotherapy-induced peripheral neuropathy
2018 Award
Principal Investigator: Stefanie Geisler (WashU Neurology)
Collaborator: Amanda Cashen (WashU Medicine), Anne Fagan (WashU Neurology)
Defining the mechanisms by which MS4A4A regulates TREM2 in Alzheimer disease
2018 Award
Principal Investigator: Celeste Karch (WashU Psychiatry)
Collaborator: Thomas Brett (WashU Medicine), Laura Piccio (WashU Neurology)
Utilizing Human Embryonic Stem Cell-Based Disease Models to Identify the Malignant Epigenetic State in Glioblastoma
2018 Award
Principal Investigator: Albert Kim (WashU Neurosurgery)
Collaborator: Andrew Yoo (WashU Developmental Biology), Jeffrey Millman (WashU Medicine)
Identification of Repurposed Prescription Medications as Neuroprotective Therapy for Amyotrophic Lateral Sclerosis
2018 Award
Principal Investigator: Brad Racette (WashU Neurology)
Collaborator: Timothy Miller (WashU Neurology)
Unraveling the Mechanisms of Neuroma Prevention with the Use of Acellularized Nerve Allografts
2017 Award
Principal Investigator: Valeria Cavalli (WashU Dept. of Neuroscience)
Collaborator: Amy Moore (WashU Surgery)
Regulation of stop codon readthrough of Aqp4 and role in Aβ clearance
2017 Award
Principal Investigator: Joseph Dougherty (WashU Genetics)
Collaborators: John Cirrito (WashU Neurology), Carla Yuede (WashU Psychiatry)
Eliciting Sensory Percepts by Macrosieve Stimulation of the Rat Sciatic Nerve
2017 Award
Principal investigator: Wilson (Zack) Ray (WashU Neurosurgery)
Collaborator: Dan Moran (WashU Biomedical Engineering)
Role of Lysosomal Dysfunction in Aggregation and Spreading of Alpha-synuclein in vitro and in vivo
2017 Award
Principal Investigator: Mark Sands (WashU Medicine)
Collaborators: Albert (Gus) Davis (WashU Neurology), Bruno Benitez (WashU Psychiatry)
Dissecting Downstream SCN Neural Circuits in Sleep and Arousal
2016 Award
Principal investigators: Aaron Norris (WashU Anesthesiology), Erik Herzog (WashU Biology)
Transmissible protein aggregation in myodegenerative diseases
2016 Award
Principal investigator: Conrad Weihl (WashU Neurology)
Collaborator: Jan Bieschke (formerly WashU Biomedical Engineering)
Development of a bioengineered construct library to repair long nerve defects
2016 Award
Principal Investigator: Matthew Wood (WashU Surgery)
Collaborator: Susan Mackinnon (WashU Surgery)
Fixing the Broken Clock: Optogenetic methods to restore circadian rhythms in a mouse model of Alzheimer’s Disease
2015 Award
Principal Investigator: Erik Musiek (WashU Neurology)
Collaborators: Erik Herzog (WashU Biology) and Geraldine Kress (WashU Neurology)
Mechanisms of neonatal seizures in a mouse model of term-equivalent cerebral hypoxia-ischemia
2015 Award
Principal Investigator: Michael Wong (WashU Neurology)
Collaborator: Rafael Galindo (WashU Neurology)
MicroRNA regulation of dendritic cell function in an animal model of multiple sclerosis
2015 Award
Principal Investigator: Gregory Wu (WashU Neurology)
Collaborator: Timothy Miller (WashU Neurology)
The role of DNA methylation in Huntington’s disease
2015 Award
Principal Investigator: Hiroko Yano (WashU Neurosurgery)
Collaborator: Ting Wang (WashU Genetics)
Neuronal subtype-specific vulnerability in tauopathies using reprogramming methods in human somatic and stem cells
2014 Award
Principal Investigator: Celeste Karch (WashU Psychiatry)
Collaborator: Andrew Yoo (WashU Developmental Biology)
Identification and functional characterization of rare variants in DNAJC5/CSP gene associated with Alzheimer Disease
2014 Award
Principal Investigators: Carlos Cruchaga (WashU Psychiatry) and Bruno Benitez (WashU Medicine)
Characterization of neural bridge circuits for spinal cord repair
2014 Award
Principal Investigator: Shelly Sakiyama-Elbert (formerly WashU Biomedical Engineering)
Collaborator: Dennis Barbour (WashU Biomedical Engineering)
MR Elastography and CSF Biomarkers in Post-Hemorrhagic Hydrocephalus
2014 Award
Principal Investigator: David Limbrick (WashU Neurosurgery)
Collaborators: Pat McAllister (WashU Neurosurgery), Philip Bayly (WashU Mechanical Engineering), Robyn Klein (WashU Medicine)
Role of nicotinamide adenine dinucleotide (NAD+) metabolism in the pathogenesis of retinal neurodegeneration
2014 Award
Principal Investigator: Shin-Ichiro Imai (WashU Developmental Biology)
Collaborator: Rajendra Apte (WashU Ophthalmology & Visual Sciences)
Promoting axonal regeneration in models of ALS via activation of the preconditioning response in iPSC-derived human neurons
2013 Award
Principal Investigator: Aaron DiAntonio (WashU Developmental Biology)
Co-Investigators: Jeffrey Milbrandt (WashU Genetics), Timothy Miller (WashU Neurology)
TREM2 signaling as a biomarker and therapeutic target in ALS
2013 Award
Principal Investigator: Matthew Harms (formerly WashU Neurology)
Co-Investigators: Timothy Miller (WashU Neurology), Marco Colonna (WashU Pathology & Immunology)
Using biosensors to identify therapy-driven brain reorganization in children
2013 Award
Principal Investigator: Bradley Schlaggar (WashU Neurology)
Co-Investigators: Nico Dosenbach (WashU Neurology), Catherine Lang (WashU Physical Therapy), Steve Petersen (WashU Neurology)
Axonal Injury in Intracerebral Hemorrhage
2012 Award
Principal Investigator: Terrance Kummer (WashU Neurology)
Co-Investigators: David Brody (formerly WashU Neurology), Gregory Zipfel (WashU Neurosurgery)
Modulation of proteostasis for treatment of Niemann-Pick C disease
2012 Award
Principal Investigator: Daniel Ory (WashU Medicine)
Co-Investigator: Mark Sands (WashU Medicine)
Immunomodulatory role of plasmacytoid dendritic cells in multiple sclerosis
2012 Award
Principal Investigator: Laura Piccio (WashU Neurology)
Co-Investigator: Marina Cella (WashU Pathology & Immunology)
DNAJB6 in protein aggregation: Integration of clinical material, mouse models and yeast genetics
2011 Award
Principal Investigator: Conrad Weihl (WashU Neurology)
Co-investigators: Heather True (WashU Cell Biology & Physiology), Matt Harms (formerly WashU Neurology)
Quantitation of Amyloid-β peptides in CSF of Alzheimer’s disease participants by immunoprecipitation/mass spectrometry (IP/MS) and solid phase extraction/mass spectrometry (SPE/MS)
2011 Award
Principal Investigators: Randall Bateman and Anne Fagan (WashU Neurology)
Isolating Cell-Type Specific miRNAs from Mice
2011 Award
Principal Investigator: Timothy Miller (WashU Neurology)
Co-investigator: Joseph Dougherty (WashU Genetics)
Noninvasive white matter histology of living EAE mice
2011 Award
Investigator: Victor Song (WashU Radiology)
Co-investigator: Anne Cross (WashU Neurology)
Citalopram Decreases Aβ Plaque Accumulation in APP Mice and CSF Aβ in Humans
2010 Award
Principal Investigator: Jin-Moo Lee (WashU Neurology)
Co-investigators: Yvette Sheline (formerly WashU Psychiatry) , Robert Swarm (WashU Anesthesiology)
Identification and functional characterization of the genetic variant causing Kufs’ disease with early dementia in a family with an autosomal dominant inheritance
2010 Award
Principal Investigator: Carlos Cruchaga (WashU Psychiatry)
Co-investigator: Mark Sands (WashU Medicine)
Cis-regulatory mapping of dominant human retinal neurodegenerative disorders
2010 Award
Principal Investigator: Joseph Corbo (WashU Pathology & Immunology)
Co-investigators: Rob Mitra (WashU Genetics), Frans Cremers (Nijmegen Medical Centre, The Netherlands)
Mechanism of Huntington Aggregation Regulated by Profilin
2010 Award
Principal Investigator: Rohit Pappu (WashU Biomedical Engineering)
Co-investigator: Marc Diamond (formerly WashU Neurology)
PET tracers for cerebrovascular-specific amyloid imaging
2009 Award
Principal Investigator: Gregory Zipfel (WashU Neurosurgery)
Co-investigators: Robert Mach (WashU Radiology), Byung Hee Han (WashU Neurosurgery)
Generating Amyloid Seeds in Lysosomes
2009 Award
Principal Investigator: Carl Frieden (WashU Biochemistry)
Co-investigators: Marc Diamond (formerly WashU Neurology), Jin-Moo Lee(WashU Neurology)
Understanding How the Liver Successfully Handles Misfolded SOD1
2009 Award
Principal Investigator: Timothy Miller (WashU Neurology)
Co-investigator: Chris Weihl (WashU Neurology)
Inhibition of the DLK/JNK Pathway as a Therapeutic Target for Axonopathy
2008 Award
Principal Investigator: Aaron DiAntonio (WashU Developmental Biology)
Co-investigator: Jeffrey Milbrandt (WashU Genetics)
Functional RNAi screen to identify pathways essential for protein aggregate clearance and degradation
2008 Award
Principal Investigator: Conrad Weihl (WashU Neurology)
Co-investigator: David Piwnica-Worms (formerly WashU Radiology)
Misfolded protein accumulation and neurodegeneration due to phospholipase gene mutations
2007 Award
Principal Investigator: Paul Kotzbauer (WashU Neurology)
Co-investigator: Joy Snider (WashU Neurology)
Function of FGF14 in progressive spinocerebellar ataxia
2007 Award
Principal Investigator: David Ornitz (WashU Developmental Biology)
Co-investigators: Kel Yamada (WashU Neurology), Jeanne Nerbonne (WashU Developmental Biology), David Wozniak (WashU Psychiatry)
Microdevice development for the study of axon degeneration and injury
2007 Award
Principal Investigator: Shelly Sakiyama-Elbert, PhD (formerly WashU Biomedical Engineering)
Co-investigators: Karen O’Malley (WashU Neuroscience), Amy Shen (formerly WashU Mechanical Engineering)
Development of a Clinically Relevant Model of Infant Traumatic Brain Injury
2007 Award
Principal Investigator: David Brody (WashU Neurology)
Co-investigators: Alexander Parsadanian (WashU Neurology), Philip Bayly (WashU Mechanical Engineering), Krikor Dikranian (WashU Neuroscience)
Unraveling the amyloid fibril with polyphenols
2006 Award
Principal Investigator: Jin-Moo Lee (WashU Neurology)
Co-investigators: Carl Frieden (WashU Biochemistry), John Heuser (WashU Cell Biology & Physiology), Rohit Pappu (WashU Biomedical Engineering), David Wozniak (WashU Psychiatry)
In vivo labeled proteomics in human CSF
2006 Award
Principal Investigator: Randall Bateman (WashU Neurology)
Co-investigators: Donald Elbert (formerly WashU Biomedical Engineering), Alison Goate (formerly WashU Psychiatry)
Use of hybrid mammalian-yeast prions to identify factors that inhibit protein aggregation (2006)
2006 Award
Principal Investigator: David Harris (formerly WashU Cell Biology & Physiology)
Co-investigator: Heather True (WashU Cell Biology & Physiology)
Genetics of Amyotrophic Lateral Sclerosis
2005 Award
Principal Investigator: Alison Goate (formerly WashU Psychiatry)
Inhibitors of Sodium Channels as Axonal Protectants in Experimental Autoimmune Encephalomyelitis
2005 Award
Principal Investigator: Anne Cross (WashU Neurology)
Stimulating Axonal Protection in ALS via Activation of Nuclear NAD Biosynthesis
2005 Award
Principal Investigators: Jeffrey Milbrandt (WashU Genetics), Anneliese Schaefer (WashU Neurology)
Active Pilot Projects
Hope Center Pilot awards are two-year projects. Click below to learn about active pilot projects.
