Promoting axonal regeneration in models of ALS via activation of the preconditioning response in iPSC-derived human neurons
2013 Award
Principal Investigator: Aaron DiAntonio (WUSTL Developmental Biology)
Co-Investigators: Jeffrey Milbrandt (WUSTL Genetics), Timothy Miller (WUSTL Neurology)
TREM2 signaling as a biomarker and therapeutic target in ALS
2013 Award
Principal Investigator: Matthew Harms (WUSTL Neurology)
Co-Investigators: Timothy Miller (WUSTL Neurology), Marco Colonna (WUSTL Pathology & Immunology)
Using biosensors to identify therapy-driven brain reorganization in children
2013 Award
Principal Investigator: Bradley Schlaggar (WUSTL Neurology)
Co-Investigators: Nico Dosenbach (WUSTL Neurology), Catherine Lang (WUSTL Physical Therapy), Steve Petersen (WUSTL Neurology)
Axonal Injury in Intracerebral Hemorrhage
2012 Award
Principal Investigator: Terrance Kummer, MD, PhD (WUSTL Neurology)
Co-Investigators: David Brody, MD, PhD (WUSTL Neurology), Gregory Zipfel, MD (WUSTL Neurosurgery)
Modulation of proteostasis for treatment of Niemann-Pick C disease
2012 Award
Principal Investigator: Daniel Ory, MD (WUSTL Internal Medicine)
Co-Investigator: Mark Sands, PhD (WUSTL Internal Medicine)
Immunomodulatory role of plasmacytoid dendritic cells in multiple sclerosis
2012 Award
Principal Investigator: Laura Piccio, MD, PhD (WUSTL Neurology)
Co-Investigator: Marina Cella, MD (WUSTL Pathology & Immunology)
DNAJB6 in protein aggregation: Integration of clinical material, mouse models and yeast genetics
2011 Award
Principal Investigator: Conrad Weihl, MD, PhD (WUSTL Neurology)
Co-investigators: Heather True-Krob, PhD (WUSTL Cell Biology & Physiology), Matt Harms, MD (WUSTL Neurology)
Quantitation of Amyloid-β peptides in CSF of Alzheimer’s disease participants by immunoprecipitation/mass spectrometry (IP/MS) and solid phase extraction/mass spectrometry (SPE/MS)
2011 Award
Principal Investigators: Randall Bateman, MD and Anne Fagan, PhD (WUSTL Neurology)
Isolating Cell-Type Specific miRNAs from Mice
2011 Award
Principal Investigator: Timothy Miller, MD, PhD (WUSTL Neurology)
Co-investigator: Joseph Dougherty, PhD (WUSTL Genetics)
Noninvasive white matter histology of living EAE mice
2011 Award
Investigator: Victor Song, PhD (WUSTL Radiology)
Co-investigator: Anne Cross, MD (WUSTL Neurology)
Citalopram Decreases Aβ Plaque Accumulation in APP Mice and CSF Aβ in Humans
2010 Award
Principal Investigator: Jin-Moo Lee, MD, PhD (WUSTL Neurology)
Co-investigators: Yvette Sheline, MD (WUSTL Psychiatry) , Robert Swarm, MD (WUSTL Anesthesiology)
Identification and functional characterization of the genetic variant causing Kufs’ disease with early dementia in a family with an autosomal dominant inheritance
2010 Award
Principal Investigator: Carlos Cruchaga, PhD (WUSTL Psychiatry)
Co-investigator: Mark Sands, PhD (WUSTL Internal Medicine)
Cis-regulatory mapping of dominant human retinal neurodegenerative disorders
2010 Award
Principal Investigator: Joseph Corbo, MD, PhD (WUSTL Pathology & Immunology)
Co-investigators: Rob Mitra, PhD (WUSTL Genetics), Frans Cremers, PhD (Nijmegen Medical Centre, The Netherlands)
Mechanism of Huntington Aggregation Regulated by Profilin
2010 Award
Principal Investigator: Rohit Pappu, PhD (WUSTL Biomedical Engineering)
Co-investigator: Marc Diamond, MD (WUSTL Neurology)
PET tracers for cerebrovascular-specific amyloid imaging
2009 Award
Principal Investigator: Gregory Zipfel, MD (WUSTL Neurosurgery)
Co-investigators: Robert Mach, PhD (WUSTL Radiology), Byung Hee Han, PhD (WUSTL Neurosurgery)
Generating Amyloid Seeds in Lysosomes
2009 Award
Principal Investigator: Carl Frieden, PhD (WUSTL Biochemistry)
Co-investigators: Marc Diamond, MD (WUSTL Neurology, Jin-Moo Lee, MD, PhD (WUSTL Neurology)
Understanding How the Liver Successfully Handles Misfolded SOD1
2009 Award
Principal Investigator: Timothy Miller, MD, PhD (WUSTL Neurology)
Co-investigator: Chris Weihl, MD, PhD (WUSTL Neurology)
Inhibition of the DLK/JNK Pathway as a Therapeutic Target for Axonopathy
2008 Award
Principal Investigator: Aaron DiAntonio, MD, PhD (WUSTL Developmental Biology)
Co-investigator: Jeffrey Milbrandt, MD, PhD (WUSTL Genetics)
Functional RNAi screen to identify pathways essential for protein aggregate clearance and degradation
2008 Award
Principal Investigator: Conrad Weihl, MD, PhD (WUSTL Neurology)
Co-investigator: David Piwnica-Worms, MD, PhD (WUSTL Radiology)
Misfolded protein accumulation and neurodegeneration due to phospholipase gene mutations
2007 Award
Principal Investigator: Paul Kotzbauer, MD, PhD (WUSTL Neurology)
Co-investigator: Joy Snider, MD, PhD (WUSTL Neurology)
Function of FGF14 in progressive spinocerebellar ataxia
2007 Award
Principal Investigator: David Ornitz, MD, PhD (WUSTL Developmental Biology)
Co-investigators: Kel Yamada, MD (WUSTL Neurology), Jeanne Nerbonne, PhD (WUSTL Developmental Biology), David Wozniak, PhD (WUSTL Psychiatry)
Microdevice development for the study of axon degeneration and injury
2007 Award
Principal Investigator: Shelly Sakiyama-Elbert, PhD (WUSTL Biomedical Engineering)
Co-investigators: Karen O’Malley, PhD (WUSTL Anatomy & Neurobiology), Amy Shen, PhD (WUSTL Mechanical Engineering)
Development of a Clinically Relevant Model of Infant Traumatic Brain Injury
2007 Award
Principal Investigator: David Brody, MD, PhD (WUSTL Neurology)
Co-investigators: Alexander Parsadanian, PhD (WUSTL Neurology), Philip Bayly, PhD (WUSTL Mechanical Engineering), Krikor Dikranian, MD, PhD (WUSTL Anatomy & Neurobiology)
Unraveling the amyloid fibril with polyphenols
2006 Award
Principal Investigator: Jin-Moo Lee, MD, PhD (WUSTL Neurology)
Co-investigators: Carl Frieden, PhD (WUSTL Biochemistry), John Heuser, MD (WUSTL Cell Biology & Physiology), Rohit Pappu, PhD (WUSTL Biomedical Engineering), David Wozniak, PhD (WUSTL Psychiatry)
In vivo labeled proteomics in human CSF
2006 Award
Principal Investigator: Randall Bateman, MD (WUSTL Neurology)
Co-investigators: Donald Elbert, PhD (WUSTL Biomedical Engineering), Alison Goate, DPhil (WUSTL Psychiatry)
Use of hybrid mammalian-yeast prions to identify factors that inhibit protein aggregation (2006)
2006 Award
Principal Investigator: David Harris, MD, PhD (WUSTL Cell Biology & Physiology)
Co-investigator: Heather True-Krob, PhD (WUSTL Cell Biology & Physiology)
Genetics of Amyotrophic Lateral Sclerosis
2005 Award
Principal Investigator: Alison Goate, DPhil (WUSTL Psychiatry)
Inhibitors of Sodium Channels as Axonal Protectants in Experimental Autoimmune Encephalomyelitis
2005 Award
Principal Investigator: Anne Cross, MD (WUSTL Neurology)
Stimulating Axonal Protection in ALS via Activation of Nuclear NAD Biosynthesis
2005 Award
Principal Investigators: Jeffrey Milbrandt, MD, PhD (WUSTL Genetics), Anneliese Schaefer, JD, PhD (WUSTL Neurology)
Active Pilot Projects
Hope Center Pilot awards are two-year projects. Click below to learn about active pilot projects.
