Fixing the Broken Clock: Optogenetic methods to restore circadian rhythms in a mouse model of Alzheimer’s Disease
2015 Award
Principal Investigator: Erik Musiek (WashU Neurology)
Collaborators: Erik Herzog (WashU Biology) and Geraldine Kress (WashU Neurology)
Mechanisms of neonatal seizures in a mouse model of term-equivalent cerebral hypoxia-ischemia
2015 Award
Principal Investigator: Michael Wong (WashU Neurology)
Collaborator: Rafael Galindo (WUSTL Neurology)
MicroRNA regulation of dendritic cell function in an animal model of multiple sclerosis
2015 Award
Principal Investigator: Gregory Wu (WashU Neurology)
Collaborator: Timothy Miller (WashU Neurology)
The role of DNA methylation in Huntington’s disease
2015 Award
Principal Investigator: Hiroko Yano (WashU Neurosurgery)
Collaborator: Ting Wang (WashU Genetics)
Neuronal subtype-specific vulnerability in tauopathies using reprogramming methods in human somatic and stem cells
2014 Award
Principal Investigator: Celeste Karch (WashU Psychiatry)
Collaborator: Andrew Yoo (WashU Developmental Biology)
Identification and functional characterization of rare variants in DNAJC5/CSP gene associated with Alzheimer Disease
2014 Award
Principal Investigators: Carlos Cruchaga (WashU Psychiatry) and Bruno Benitez (WashU Medicine)
Characterization of neural bridge circuits for spinal cord repair
2014 Award
Principal Investigator: Shelly Sakiyama-Elbert (formerly WashU Biomedical Engineering)
Collaborator: Dennis Barbour (WashU Biomedical Engineering)
MR Elastography and CSF Biomarkers in Post-Hemorrhagic Hydrocephalus
2014 Award
Principal Investigator: David Limbrick (WashU Neurosurgery)
Collaborators: Pat McAllister (WashU Neurosurgery), Philip Bayly (WashU Mechanical Engineering), Robyn Klein (WashU Medicine)
Role of nicotinamide adenine dinucleotide (NAD+) metabolism in the pathogenesis of retinal neurodegeneration
2014 Award
Principal Investigator: Shin-Ichiro Imai (WashU Developmental Biology)
Collaborator: Rajendra Apte (WashU Ophthalmology & Visual Sciences)
Promoting axonal regeneration in models of ALS via activation of the preconditioning response in iPSC-derived human neurons
2013 Award
Principal Investigator: Aaron DiAntonio (WashU Developmental Biology)
Co-Investigators: Jeffrey Milbrandt (WashU Genetics), Timothy Miller (WashU Neurology)
TREM2 signaling as a biomarker and therapeutic target in ALS
2013 Award
Principal Investigator: Matthew Harms (formerly WashU Neurology)
Co-Investigators: Timothy Miller (WashU Neurology), Marco Colonna (WashU Pathology & Immunology)
Using biosensors to identify therapy-driven brain reorganization in children
2013 Award
Principal Investigator: Bradley Schlaggar (WashU Neurology)
Co-Investigators: Nico Dosenbach (WashU Neurology), Catherine Lang (WashU Physical Therapy), Steve Petersen (WashU Neurology)
Axonal Injury in Intracerebral Hemorrhage
2012 Award
Principal Investigator: Terrance Kummer, MD, PhD (WashU Neurology)
Co-Investigators: David Brody, MD, PhD (WashU Neurology), Gregory Zipfel, MD (WashU Neurosurgery)
Modulation of proteostasis for treatment of Niemann-Pick C disease
2012 Award
Principal Investigator: Daniel Ory, MD (WashU Medicine)
Co-Investigator: Mark Sands, PhD (WashU Medicine)
Immunomodulatory role of plasmacytoid dendritic cells in multiple sclerosis
2012 Award
Principal Investigator: Laura Piccio, MD, PhD (WashU Neurology)
Co-Investigator: Marina Cella, MD (WashU Pathology & Immunology)
DNAJB6 in protein aggregation: Integration of clinical material, mouse models and yeast genetics
2011 Award
Principal Investigator: Conrad Weihl, MD, PhD (WashU Neurology)
Co-investigators: Heather True-Krob, PhD (WashU Cell Biology & Physiology), Matt Harms, MD (formerly WashU Neurology)
Quantitation of Amyloid-β peptides in CSF of Alzheimer’s disease participants by immunoprecipitation/mass spectrometry (IP/MS) and solid phase extraction/mass spectrometry (SPE/MS)
2011 Award
Principal Investigators: Randall Bateman, MD and Anne Fagan, PhD (WashU Neurology)
Isolating Cell-Type Specific miRNAs from Mice
2011 Award
Principal Investigator: Timothy Miller, MD, PhD (WashU Neurology)
Co-investigator: Joseph Dougherty, PhD (WashU Genetics)
Noninvasive white matter histology of living EAE mice
2011 Award
Investigator: Victor Song, PhD (WashU Radiology)
Co-investigator: Anne Cross, MD (WashU Neurology)
Citalopram Decreases Aβ Plaque Accumulation in APP Mice and CSF Aβ in Humans
2010 Award
Principal Investigator: Jin-Moo Lee, MD, PhD (WashU Neurology)
Co-investigators: Yvette Sheline, MD (formerly WashU Psychiatry) , Robert Swarm, MD (WashU Anesthesiology)
Identification and functional characterization of the genetic variant causing Kufs’ disease with early dementia in a family with an autosomal dominant inheritance
2010 Award
Principal Investigator: Carlos Cruchaga, PhD (WashU Psychiatry)
Co-investigator: Mark Sands, PhD (WashU Medicine)
Cis-regulatory mapping of dominant human retinal neurodegenerative disorders
2010 Award
Principal Investigator: Joseph Corbo, MD, PhD (WashU Pathology & Immunology)
Co-investigators: Rob Mitra, PhD (WashU Genetics), Frans Cremers, PhD (Nijmegen Medical Centre, The Netherlands)
Mechanism of Huntington Aggregation Regulated by Profilin
2010 Award
Principal Investigator: Rohit Pappu, PhD (WashU Biomedical Engineering)
Co-investigator: Marc Diamond, MD (formerly WashU Neurology)
PET tracers for cerebrovascular-specific amyloid imaging
2009 Award
Principal Investigator: Gregory Zipfel, MD (WashU Neurosurgery)
Co-investigators: Robert Mach, PhD (WashU Radiology), Byung Hee Han, PhD (WashU Neurosurgery)
Generating Amyloid Seeds in Lysosomes
2009 Award
Principal Investigator: Carl Frieden, PhD (WashU Biochemistry)
Co-investigators: Marc Diamond, MD (formerly WashU Neurology), Jin-Moo Lee, MD, PhD (WashU Neurology)
Understanding How the Liver Successfully Handles Misfolded SOD1
2009 Award
Principal Investigator: Timothy Miller, MD, PhD (WashU Neurology)
Co-investigator: Chris Weihl, MD, PhD (WashU Neurology)
Inhibition of the DLK/JNK Pathway as a Therapeutic Target for Axonopathy
2008 Award
Principal Investigator: Aaron DiAntonio, MD, PhD (WashU Developmental Biology)
Co-investigator: Jeffrey Milbrandt, MD, PhD (WashU Genetics)
Functional RNAi screen to identify pathways essential for protein aggregate clearance and degradation
2008 Award
Principal Investigator: Conrad Weihl, MD, PhD (WashU Neurology)
Co-investigator: David Piwnica-Worms, MD, PhD (formerly WashU Radiology)
Misfolded protein accumulation and neurodegeneration due to phospholipase gene mutations
2007 Award
Principal Investigator: Paul Kotzbauer, MD, PhD (WashU Neurology)
Co-investigator: Joy Snider, MD, PhD (WashU Neurology)
Function of FGF14 in progressive spinocerebellar ataxia
2007 Award
Principal Investigator: David Ornitz, MD, PhD (WashU Developmental Biology)
Co-investigators: Kel Yamada, MD (WashU Neurology), Jeanne Nerbonne, PhD (WashU Developmental Biology), David Wozniak, PhD (WashU Psychiatry)
Microdevice development for the study of axon degeneration and injury
2007 Award
Principal Investigator: Shelly Sakiyama-Elbert, PhD (formerly WashU Biomedical Engineering)
Co-investigators: Karen O’Malley, PhD (WashU Neuroscience), Amy Shen, PhD (formerly WashU Mechanical Engineering)
Development of a Clinically Relevant Model of Infant Traumatic Brain Injury
2007 Award
Principal Investigator: David Brody, MD, PhD (WashU Neurology)
Co-investigators: Alexander Parsadanian, PhD (WashU Neurology), Philip Bayly, PhD (WashU Mechanical Engineering), Krikor Dikranian, MD, PhD (WashU Neuroscience)
Unraveling the amyloid fibril with polyphenols
2006 Award
Principal Investigator: Jin-Moo Lee, MD, PhD (WashU Neurology)
Co-investigators: Carl Frieden, PhD (WashU Biochemistry), John Heuser, MD (WashU Cell Biology & Physiology), Rohit Pappu, PhD (WashU Biomedical Engineering), David Wozniak, PhD (WashU Psychiatry)
In vivo labeled proteomics in human CSF
2006 Award
Principal Investigator: Randall Bateman, MD (WashU Neurology)
Co-investigators: Donald Elbert, PhD (formerly WashU Biomedical Engineering), Alison Goate, DPhil (formerly WashU Psychiatry)
Use of hybrid mammalian-yeast prions to identify factors that inhibit protein aggregation (2006)
2006 Award
Principal Investigator: David Harris, MD, PhD (formerly WashU Cell Biology & Physiology)
Co-investigator: Heather True-Krob, PhD (WashU Cell Biology & Physiology)
Genetics of Amyotrophic Lateral Sclerosis
2005 Award
Principal Investigator: Alison Goate, DPhil (formerly WashU Psychiatry)
Inhibitors of Sodium Channels as Axonal Protectants in Experimental Autoimmune Encephalomyelitis
2005 Award
Principal Investigator: Anne Cross, MD (WashU Neurology)
Stimulating Axonal Protection in ALS via Activation of Nuclear NAD Biosynthesis
2005 Award
Principal Investigators: Jeffrey Milbrandt, MD, PhD (WashU Genetics), Anneliese Schaefer, JD, PhD (WashU Neurology)
Active Pilot Projects
Hope Center Pilot awards are two-year projects. Click below to learn about active pilot projects.
