Past Pilot Projects

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Neuronal subtype-specific vulnerability in tauopathies using reprogramming methods in human somatic and stem cells

2014 Award
Principal Investigator: Celeste Karch (WashU Psychiatry)
Collaborator: Andrew Yoo (WashU Developmental Biology)

Pilot Project Details

Identification and functional characterization of rare variants in DNAJC5/CSP gene associated with Alzheimer Disease

2014 Award
Principal Investigators: Carlos Cruchaga (WashU Psychiatry) and Bruno Benitez (WashU Medicine)

Pilot Project Details

Characterization of neural bridge circuits for spinal cord repair

2014 Award
Principal Investigator: Shelly Sakiyama-Elbert (WashU Biomedical Engineering)
Collaborator: Dennis Barbour (WashU Biomedical Engineering)

Pilot Project Details

MR Elastography and CSF Biomarkers in Post-Hemorrhagic Hydrocephalus

2014 Award
Principal Investigator: David Limbrick (WashU Neurosurgery)
Collaborators: Pat McAllister (WashU Neurosurgery), Philip Bayly (WashU Mechanical Engineering), Robyn Klein (WashU Medicine)

Pilot Project Details

Role of nicotinamide adenine dinucleotide (NAD+) metabolism in the pathogenesis of retinal neurodegeneration

2014 Award
Principal Investigator: Shin-Ichiro Imai (WashU Developmental Biology)
Collaborator: Rajendra Apte (WashU Ophthalmology & Visual Sciences)

Pilot Project Details

Promoting axonal regeneration in models of ALS via activation of the preconditioning response in iPSC-derived human neurons

2013 Award
Principal Investigator: Aaron DiAntonio (WashU Developmental Biology)
Co-Investigators: Jeffrey Milbrandt (WashU Genetics), Timothy Miller (WashU Neurology)

Pilot Project Details

TREM2 signaling as a biomarker and therapeutic target in ALS

2013 Award
Principal Investigator: Matthew Harms (WashU Neurology)
Co-Investigators: Timothy Miller (WashU Neurology), Marco Colonna (WashU Pathology & Immunology)

Pilot Project Details

Using biosensors to identify therapy-driven brain reorganization in children

2013 Award
Principal Investigator: Bradley Schlaggar (WashU Neurology)
Co-Investigators: Nico Dosenbach (WashU Neurology), Catherine Lang (WashU Physical Therapy), Steve Petersen (WashU Neurology)

Pilot Project Details

Axonal Injury in Intracerebral Hemorrhage

2012 Award
Principal Investigator: Terrance Kummer, MD, PhD (WashU Neurology)
Co-Investigators: David Brody, MD, PhD (WashU Neurology), Gregory Zipfel, MD (WashU Neurosurgery)

Pilot Project Details

Modulation of proteostasis for treatment of Niemann-Pick C disease

2012 Award
Principal Investigator: Daniel Ory, MD (WashU Medicine)
Co-Investigator: Mark Sands, PhD (WashU Medicine)

Pilot Project Details

Immunomodulatory role of plasmacytoid dendritic cells in multiple sclerosis

2012 Award
Principal Investigator: Laura Piccio, MD, PhD (WashU Neurology)
Co-Investigator: Marina Cella, MD (WashU Pathology & Immunology)

Pilot Project Details

DNAJB6 in protein aggregation: Integration of clinical material, mouse models and yeast genetics

2011 Award
Principal Investigator: Conrad Weihl, MD, PhD (WashU Neurology)
Co-investigators: Heather True-Krob, PhD (WashU Cell Biology & Physiology), Matt Harms, MD (WashU Neurology)

Pilot Project Details

Quantitation of Amyloid-β peptides in CSF of Alzheimer’s disease participants by immunoprecipitation/mass spectrometry (IP/MS) and solid phase extraction/mass spectrometry (SPE/MS)

2011 Award
Principal Investigators: Randall Bateman, MD and Anne Fagan, PhD (WashU Neurology)

Pilot Project Details

Isolating Cell-Type Specific miRNAs from Mice

2011 Award
Principal Investigator: Timothy Miller, MD, PhD (WashU Neurology)
Co-investigator: Joseph Dougherty, PhD (WashU Genetics)

Pilot Project Details

Noninvasive white matter histology of living EAE mice

2011 Award
Investigator: Victor Song, PhD (WashU Radiology)
Co-investigator: Anne Cross, MD (WashU Neurology)

Pilot Project Details

Citalopram Decreases Aβ Plaque Accumulation in APP Mice and CSF Aβ in Humans

2010 Award
Principal Investigator: Jin-Moo Lee, MD, PhD (WashU Neurology)
Co-investigators: Yvette Sheline, MD (WashU Psychiatry) , Robert Swarm, MD (WashU Anesthesiology)

Pilot Project Details

Identification and functional characterization of the genetic variant causing Kufs’ disease with early dementia in a family with an autosomal dominant inheritance

2010 Award
Principal Investigator: Carlos Cruchaga, PhD (WashU Psychiatry)
Co-investigator: Mark Sands, PhD (WashU Medicine)

Pilot Project Details

Cis-regulatory mapping of dominant human retinal neurodegenerative disorders

2010 Award
Principal Investigator: Joseph Corbo, MD, PhD (WashU Pathology & Immunology)
Co-investigators: Rob Mitra, PhD (WashU Genetics), Frans Cremers, PhD (Nijmegen Medical Centre, The Netherlands)

Pilot Project Details

Mechanism of Huntington Aggregation Regulated by Profilin

2010 Award
Principal Investigator: Rohit Pappu, PhD (WashU Biomedical Engineering)
Co-investigator: Marc Diamond, MD (WashU Neurology)

Pilot Project Details

 

PET tracers for cerebrovascular-specific amyloid imaging

2009 Award
Principal Investigator: Gregory Zipfel, MD (WashU Neurosurgery)
Co-investigators: Robert Mach, PhD (WashU Radiology), Byung Hee Han, PhD (WashU Neurosurgery)

Pilot Project Details

Generating Amyloid Seeds in Lysosomes

2009 Award
Principal Investigator: Carl Frieden, PhD (WashU Biochemistry)
Co-investigators: Marc Diamond, MD (WashU Neurology, Jin-Moo Lee, MD, PhD (WashU Neurology)

Pilot Project Details

Understanding How the Liver Successfully Handles Misfolded SOD1

2009 Award
Principal Investigator: Timothy Miller, MD, PhD (WashU Neurology)
Co-investigator: Chris Weihl, MD, PhD (WashU Neurology)

Pilot Project Details

Inhibition of the DLK/JNK Pathway as a Therapeutic Target for Axonopathy

2008 Award
Principal Investigator: Aaron DiAntonio, MD, PhD (WashU Developmental Biology)
Co-investigator: Jeffrey Milbrandt, MD, PhD (WashU Genetics)

Pilot Project Details

Functional RNAi screen to identify pathways essential for protein aggregate clearance and degradation

2008 Award
Principal Investigator: Conrad Weihl, MD, PhD (WashU Neurology)
Co-investigator: David Piwnica-Worms, MD, PhD (WashU Radiology)

Pilot Project Details

Misfolded protein accumulation and neurodegeneration due to phospholipase gene mutations

2007 Award
Principal Investigator: Paul Kotzbauer, MD, PhD (WashU Neurology)
Co-investigator: Joy Snider, MD, PhD (WashU Neurology)

Pilot Project Details

Function of FGF14 in progressive spinocerebellar ataxia

2007 Award
Principal Investigator: David Ornitz, MD, PhD (WashU Developmental Biology)
Co-investigators: Kel Yamada, MD (WashU Neurology), Jeanne Nerbonne, PhD (WashU Developmental Biology), David Wozniak, PhD (WashU Psychiatry)

Pilot Project Details

Microdevice development for the study of axon degeneration and injury

2007 Award
Principal Investigator: Shelly Sakiyama-Elbert, PhD (WashU Biomedical Engineering)
Co-investigators: Karen O’Malley, PhD (WashU Anatomy & Neurobiology), Amy Shen, PhD (WashU Mechanical Engineering)

Pilot Project Details

Development of a Clinically Relevant Model of Infant Traumatic Brain Injury

2007 Award
Principal Investigator: David Brody, MD, PhD (WashU Neurology)
Co-investigators: Alexander Parsadanian, PhD (WashU Neurology), Philip Bayly, PhD (WashU Mechanical Engineering), Krikor Dikranian, MD, PhD (WashU Anatomy & Neurobiology)

Pilot Project Details

Unraveling the amyloid fibril with polyphenols

2006 Award
Principal Investigator: Jin-Moo Lee, MD, PhD (WashU Neurology)
Co-investigators: Carl Frieden, PhD (WashU Biochemistry), John Heuser, MD (WashU Cell Biology & Physiology), Rohit Pappu, PhD (WashU Biomedical Engineering), David Wozniak, PhD (WashU Psychiatry)

Pilot Project Details

In vivo labeled proteomics in human CSF

2006 Award
Principal Investigator: Randall Bateman, MD (WashU Neurology)
Co-investigators: Donald Elbert, PhD (WashU Biomedical Engineering), Alison Goate, DPhil (WashU Psychiatry)

Pilot Project Details

Use of hybrid mammalian-yeast prions to identify factors that inhibit protein aggregation (2006)

2006 Award
Principal Investigator: David Harris, MD, PhD (WashU Cell Biology & Physiology)
Co-investigator: Heather True-Krob, PhD (WashU Cell Biology & Physiology)

Pilot Project Details

Genetics of Amyotrophic Lateral Sclerosis

2005 Award
Principal Investigator: Alison Goate, DPhil (WashU Psychiatry)

Inhibitors of Sodium Channels as Axonal Protectants in Experimental Autoimmune Encephalomyelitis

2005 Award
Principal Investigator: Anne Cross, MD (WashU Neurology)

Stimulating Axonal Protection in ALS via Activation of Nuclear NAD Biosynthesis

2005 Award
Principal Investigators: Jeffrey Milbrandt, MD, PhD (WashU Genetics), Anneliese Schaefer, JD, PhD (WashU Neurology)

Active Pilot Projects

Hope Center Pilot awards are two-year projects.  Click below to learn about active pilot projects.

Active pilot projects