January 16, 2018
Chris Weihl, MD, PhD: Course Introduction
January 23, 2018
Erik Musiek, MD, PhD: Alzheimer’s Disease
- Clinical and biomarker changes in dominantly inherited Alzheimer’s disease
- TREM2 Maintains Microglial Metabolic Fitness in Alzheimer’s Disease
Review: Three dimensions of the amyloid hypothesis: time, space and ‘wingmen’
January 30, 2018
Deanna Barch, PhD: Psychiatric disorders
- Schizophrenia risk alleles and neurodevelopmental outcomes in childhood: a population-based cohort study
- Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium
Review: The nature of dopamine dysfunction in schizophrenia and what this means for treatment
February 6, 2018
Toni Pearson, MD: Child metabolic
- Brain microvasculature defects and Glut1 deficiency syndrome averted by early repletion of the glucose transporter-1 protein
- GLUT1 mutations are a cause of paroxysmal exertion-induced dyskinesias and induce hemolytic anemia by a cation leak
Review:
- Defective glucose transport across the blood-brain barrier as a cause of persistent hypoglycorrhachia, seizures, and developmental delay (initial description)
- Phenotypic spectrum of glucose transporter type 1 deficiency syndrome (Glut1 DS)
February 13, 2018
Stefanie Geisler, MD, PhD: Neuropathy
- Gut microbiota is critical for the induction of chemotherapy-induced pain
- Pharmacological augmentation of nicotinamide phosphoribosyltransferase (NAMPT) protects against paclitaxel-induced peripheral neuropathy
Review: Chemotherapy-induced peripheral neuropathy: A current review
February 20, 2018
Mike Wong, MD, PhD: Epilepsy
- Somatic mutations in TSC1 and TSC2 cause focal cortical dysplasia
- Neuronal hyperexcitability in a mouse model of SCN8A epileptic encephalopathy
Review: Molecular mechanisms of epilepsy
February 27, 2018
Milan Chheda, MD, PhD: Neuro-oncology
- Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
- Identification of a cancer stem cell in human brain tumors
Review: Identification of human brain tumour initiating cells
March 6, 2018
O’Leary Prize
March 13, 2018
Spring Break
March 20, 2018
Tim Miller, MD, PhD: ALS
- TIA1 mutations in amyotrophic lateral sclerosis and frontotemporal dementia promote phase separation and alter stress granule dynamics
- Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons
March 27, 2018
Alex Carter, MD, PhD: Neuro-Rehabilitation
- Frontal lesions predict response to prism adaptation treatment in spatial neglect – a randomized controlled study
- Theta burst stimulation reduces disability during the activities of daily living in spatial neglect
April 3, 2018
Yo-El Ju, MD: Sleep
- Loss of dorsolateral nigral hyperintensity on 3.0 tesla susceptibility-weighted imaging in idiopathic rapid eye movement sleep behavior disorder
- Assessment of α-synuclein in submandibular glands of patients with idiopathic rapid-eye-movement sleep behaviour disorder: a case-control study
Review: Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease
April 10, 2018
Hope Center Retreat
April 17, 2018
Chris Weihl, MD, PhD: Myositis
- Targeting protein homeostasis in sporadic inclusion body myositis
- Inclusion body myositis functional rating scale: a reliable and valid measure of disease severity
- A prospective natural history study of inclusion body myositis: implications for clinical trials
April 24, 2018
Pietro Mazzoni, MD, PhD: Movement disorders
