2017/2018 Monday Noon Seminars

Archive of mini-series topics and speakers Read More

2017/2018 Schedule

Mondays, 12-1p
September – June
Holden Auditorium (Farrell Learning and Teaching Center)

Mini-Series Topics:

Role of Glia in Neurodegeneration
Addiction and Reward System
Microbiome and Neurological Disease
Neuronal Aging and Proteostasis

Special Hope Center Seminars

Role of Glia in Neurodegeneration

Organizer, Erik Musiek

  • October 30: Beau Ances (WashU Neurology) “Imaging of Microglia using PET and MRI”
  • November 6: Tyler Ulland (Colonna Lab, WashU Pathology & Immunology) “Trem2: key to microglial fitness in Alzheimer’s disease”
  • November 27: Robyn Klein (WashU Medicine) “Glia Reprogram Brain Function During WNV Encephalitis”
  • December 4: Joseph Dougherty (WashU Genetics) “Astrocyte alternative translation and neurological disease”
  • December 11: Erik Musiek (WashU Neurology) “Circadian regulation of neuroinflammation”
  • December 18: Kim Green (University of California, Irvine) “Exploring the roles of microglia in the pathogenesis of Alzheimer’s disease”

Addiction and Reward System

Organizer, Michael Bruchas

  • January 8: Julia Lemos (University of Minnesota) “Restructuring of basal ganglia circuitry and associated behaviors triggered by low striatal D2 receptor expression: implications for substance use disorders”
  • January 22: Jose Moron-Concepcion (WashU Anesthesiology) “Opioid-induced plasticity and the intersection with pain”
  • CANCELLED January 29: Ream Al-Hasani (St. Louis College of Pharmacy/WashU Anesthesiology)  “Dissecting endogenous opioid systems in motivated behaviors”
  • February 5: Ilya Monosov (WashU Dept. of Neuroscience) “Why would you want to know? Brain networks for uncertainty reduction”

Microbiome and Neurological Disease

Organizer, Laura Piccio

  • February 19: Larissa Thackray (WashU Medicine) “The Role of the Gut Microbiota in Neurotropic Flavivirus Infection”
  • February 26: Barbara Warner (WashU Pediatrics) “The Gut Microbiome Contribution to Neurodevelopment and Neuropsychiatric Disorders”
  • March 5: Yanjiao Zhou (The Jackson Laboratory), Laura Piccio (WashU Neurology) “Intermittent fasting and gut microbiome in CNS autoimmunity”
  • March 12: Barbara Bendlin (University of Wisconsin) “From fringe to foreground: do microbes play a role in Alzheimer’s?”


Organizers, Chris Weihl and Timothy Miller

  • March 19: Timothy Miller (WashU Neurology) “ALS and Frontotemporal Dementia” 
  • March 26: Yuna Ayala (Saint Louis University) “Walking the tightrope: an emerging role of RNA binding proteins in ALS and FTD” 
  • April 9:  Clotilde Lagier-Tourenne (Harvard Medical School) “Modeling C9ORF72 disease: a crucial step for therapeutic development in ALS/FTD”
  • April 16: Meredith Jackrel (WashU Chemistry) “Protein disaggregases to counter TDP-43, FUS, DPR, and SOD1 misfolding implicated in ALS”

Neuronal Aging and Proteostasis

Organizer, Andrew Yoo and Samantha Morris (co-hosted with the Department of Developmental Biology)

  • April 30: Fumihiko Urano (WashU Medicine) “Precision Medicine for Endoplasmic Reticulum Disease”
  • May 7: Erik Musiek (WashU Neurology) “Differential regulation of amyloid-beta and tau by the circadian clock”
  • May 14: Shin-Ichiro Imai (WashU Developmental Biology) “Achieving Productive Aging Based on the NAD World 2.0: The Importance of eNAMPT and the NMN Transporter”
  • May 21 at 10:00a: Anne Bertolotti (MRC Laboratory of Molecular Biology, UK) “Boosting protein quality control to prevent neurodegenerative diseases”
    NOTE time


Special Seminars

  • October 2: Vikram Shakkottai (University of Michigan Medicine), “Targeting neuronal dysfunction in cerebellar ataxia” 
  • November 20: David Holtzman, “State of the Hope Center”
  • June 4: Winners, Hope Center Awards
    Scott Karney-Grobe (DiAntonio Lab, Developmental Biology) “HSP90 is a chaperone for DLK and is required for axon injury signaling”
    Alex Cammack (Miller Lab, Neurology) “C9orf72 G4C2 repeat expansions in ALS patients are dynamic and result in large dipeptide repeat proteins”