Jin-Moo Lee Lab

Amyloid plaque pathogenesis
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Research Overview

A primary research interest in the lab is to understand mechanisms in the brain that lead to the appearance and growth of amyloid plaques using cellular and mouse models of Alzheimer’s disease.  We are investigating cellular models to examine the possibility that the seeds for amyloid plaques are generated inside the cells in lysosomally-derived vesicles.  We hypothesize that nascent aggregates of the Aß peptide generated in lysosomes are extruded to the extracellular space where they may form seeds for the generation of amyloid plaques.   Using mouse models of Alzheimer’s disease, we are also interested in understanding factors that influence plaque appearance and growth, including extracellular Aß concentrations, reactive gliosis, and neuronal activity.

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