Defining the mechanisms by which MS4A4A regulates TREM2 in Alzheimer disease

2018 Pilot Project Read More


Principal Investigator: Celeste Karch (WashU Psychiatry)
Collaborator: Thomas Brett (WashU Medicine), Laura Piccio (WashU Neurology)


Alzheimer’s disease is the most common neurodegenerative disease; however, there are currently no effective means of prevention or treatment. Human genetic and animal models have recently implicated the TREM2 gene in microglial function and in AD pathogenesis. In this proposal, we will study the mechanism by which a novel regulator of TREM2 influences AD risk using molecular and biochemical approaches in stem cell models. The results of this project will provide the mechanistic framework needed to develop treatments that restore or enhance TREM2 functions in order to prevent neurodegenerative disease.


Pilot project teams include Hope Center faculty members and others. For more about Hope Center faculty on this team, click below.

Celeste Karch

Laura Piccio