2018 Hope Center Retreat

April 10, 2018: Danforth Plant Science Center Read More

Program, 2018 Retreat

Welcome and Opening Remarks from David Holtzman, MD and Anneliese Schaefer, JD, PhD

Hope Center Lecture – Leonard Petrucelli, PhD (Mayo Clinic Florida) 

“Mechanistic and Therapeutic Insights into c9FTD/ALS”

Session 1: Neurodegeneration Group (Chair: Timothy Miller, MD, PhD (Neurology))

  • Kiersten Ruff, PhD (Pappu Lab, Biomedical Engineering)
    “Polyglutamine length dependent structural properties and phase behavior of huntingtin exon 1”
  • Tien-Phat Huynh (Holtzman Lab, Neurology)
    “Age-dependent effects of apoE reduction using antisense oligonucleotides in a model of β-amyloidosis”

Session 2: Lysosome Processing & Transport Group (Chair: Bruno Benitez, MD (Medicine)); NeuroRestorative Therapy Group (Chairs: Albert Kim, MD, PhD (Neurosurgery) and Fumihiko Urano, MD, PhD (Medicine))

  • Devi Annamalai, PhD (Kim Lab, Neurosurgery)
    “Epigenomic reprogramming as a therapeutic strategy for malignant gliomas”
  • Sidhartha Mahali, PhD (Karch Lab, Psychiatry)
    “Lysosomal dysfunction and altered tau metabolism in stem cell models of autosomal dominant Alzheimer’s disease”

Session 3: Neurovascular Injury & Repair Group (Chair: Jin-Moo Lee, MD, PhD (Neurology))

  • Charise Garber (Klein Lab, Medicine)
    “T-cells promote microglial activation and prevent cognitive recovery from viral encephalitis via interferon gamma”
  • Deepti Diwan, PhD (Zipfel Lab, Neurosurgery)
    “Sirt1 mediates hypoxic conditioning-induced delayed cerebral ischemia protection in subarachnoid hemorrhage”

Session 4: Neurogenetics & Transcriptomics Group (Chair: Carlos Cruchaga, PhD (Psychiatry))

  • Umber Dube (Cruchaga Lab, Psychiatry)
    “Circular RNAs in Alzheimers disease brain tissues”
  • Denis Avey, PhD (Milbrandt Lab, Genetics)
    “Single cell RNA-seq facilitates characterization of glial and neuronal responses to morphine”

Session 5: Axon Injury & Repair Group (Chair: Valeria Cavalli, PhD (Neuroscience))

  • Scott Karney-Grobe (DiAntonio Lab, Developmental Biology)
    “HSP90 is a chaperone for DLK and is required for axon injury signaling”
  • Deng Pan (Mackinnon Lab, Surgery)
    “Reduced T cell accumulation in long gap nerve injuries inhibit peripheral nerve regeneration”

Poster session