Principal Investigator: Oscar Harari (WashU Psychiatry)
Collaborator: Ting Wang (WashU Genetics)
Alzheimer’s disease (AD) is the most common neurodegenerative disease, but currently there is no effective means of prevention or treatment. Age is the major risk factor for AD, but AD is not a normal part of aging. The cause of AD is complex and not specific to a single genetic factor or brain cell-type. DNA methylation is a reversible process that can modulate the expression of genes, without changing the genetic sequence. It varies across the lifespan and its levels are influenced by lifestyle and environmental and genetic factors 11. Through the execution of this project we will study the age-related changes in DNA methylation in AD and in individuals who do not show AD-related brain changes. Our results will provide a better understanding of the molecular mechanisms that drive AD pathogenesis.
Pilot project teams include Hope Center faculty members and others. For more about Hope Center faculty on this team, click below.