Program, 2019 Retreat
Welcome and Opening Remarks – David Holtzman, MD and Anneliese Schaefer, JD, PhD
Session 1: Lysosome Processing & Transport Group
Lysosome Chair: Bruno Benitez, MD (Psychiatry)
- Leah Czerniewski (Lee Lab, Neurology)
“Tracking the intracellular itinerary of APP and de novo Aβ generation using click chemistry” - Andrew Findlay, MD (Weihl Lab, Neurology)
“Lithium chloride corrects weakness and myopathology in a preclinical model of LGMD1D”
Session 2: Protein Aggregation & Neurodegeneration Group
Neurodegeneration Chair: Timothy Miller, MD, PhD (Neurology)
- Fabia Filipello, PhD (Piccio Lab, Neurology/Karch Lab, Psychiatry)
“The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer disease risk” - Rachel French, PhD (Ayala Lab, SLU Biochemistry)
“TDP-43 oligomers detected as initial intermediate species during aggregate formation“
Session 3: Neurogenetics & Transcriptomics Group
Neurogenetics Chair: Oscar Harari, PhD (Psychiatry)
- Matthew Lalli, PhD (Mitra/Milbrandt Labs, Genetics)
“Rapid high-throughput single-cell neurodevelopmental disease modeling” - Michael Vasek, PhD (Dougherty Lab, Genetics)
“Microglia: Local translation and synaptic homeostasis”
Hope Center Lecture – Guoping Feng, PhD (Massachusetts Institute of Technology)
“Dissecting synaptic and circuitry mechanisms of psychiatric disorders”
Hope Center Lecture – Sally Temple, PhD (Neural Stem Cell Institute)
”Neural stem cells in aging and modeling neurodegenerative disease”
Session 4: Clocks & Sleep Club and NeuroRestorative Therapy Group
Clocks & Sleep Chair: Yao Chen, PhD (Neuroscience)
NeuroRestorative Chair: Fumihiko Urano, MD, PhD (Medicine)
- Percy Griffin (Musiek Lab, Neurology)
“Circadian regulation of neuroinflammation and neurodegeneration by Rev-erbα” - Sindhu Manivasagam (Klein Lab, Medicine)
“Investigating type III interferons as a novel therapeutic target during autoimmune neuroinflammation”
Session 5: Neurovascular Injury & Repair and Axon Injury & Repair Groups
Neurovascular Chair: Jin Moo Lee, MD, PhD (Neurology)
Axon Chair: Valeria Cavalli, PhD (Neuroscience)
- Hailun Li (DiAntonio Lab, Developmental Biology)
“A novel potassium buffering mechanism for neuroprotection against ischemic stroke” - Satya Kothapalli, PhD (Yablonskiy Lab, Radiology)
“In vivo measurements of Alzheimer disease-related neuronal loss in the hippocampal subfields with quantitative Gradient Recalled Echo (qGRE) MRI”
Poster session
