Zipfel Research Projects

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Cerebral Amyloid Angiopathy, Vascular Dysfunction & Ischemic Brain Injury

NIH-NINDS
The major goal of this project is to understand the role of CAA in vasomotor impairment, cerebral blood flow, and focal ischemic brain injury using a transgenic animal model.

Pathogenesis of CAA-induced neurovascular dysfunction

NIH-NINDS
The major goal of this project is to understand whether CAA is contributing to vascular dysfunction and brain injury using ex vivo and in vivo model systems; and to determine the impact of ApoE on CAA-related pathology.

A-beta peptide as mediator of Apolipoprotein E4’s effect on cerebral vasospasm

American Heart Association
The major goal of this project is to examine if ApoE4 exacerbates cerebral vasospasm after experimental subarachnoid hemorrhage in mice; and if so, whether this is Aβ-mediated.

Endogenous Protective Mechanisms Against Cerebral Vasospasm

Brain Aneurysm Foundation, Anna Orthwein Chair of Research
The major goal of this project is to elucidate the underlying mechanisms of hypoxic preconditioning-induced protection against cerebral vasospasm following experimental subarachnoid hemorrhage in mice.

PET tracers for cerebrovascular-specific amyloid imaging

Hope Center for Neurological Disorders
The major goal of this project is to develop novel cerebrovascular-specific amyloid-binding agents that can be radiolabeled and utilized as PET tracers.

Selective PET tracers for Human Cerebral Amyloid Angiopathy

Knight Alzheimer’s Disease Research Center
The major goal of this project is to determine whether newly identified cerebrovascular-specific amyloid-binding agents (first identified in mouse models) have selectivity for cerebral amyloid angiopathy in humans.

Role of Matrix metalloproteinase-9 in vasospasm after subarachnoid hemorrhage

McDonnell Center for Cellular and Molecular Neurobiology
The goal of this project was to explore molecular mechanisms by which MMP-9 activation contributes to cerebral vasospasm following subarachnoid hemorrhage.

Matrix metalloproteinase-9 in neurovascular dysfunction following SAH

The Brain Aneurysm foundation
The goal of this project is to examine whether MMP-9 activation contributes to brain edema and the blood-brain barrier integrity after subarachnoid hemorrhage and pharmacological MMP-9 inhibition affords a promising new therapeutic approach towards amelioration of SAH brain injury.

PET tracers for cerebrovascular-specific amyloid imaging

American Health Assistance Foundation
The goal of this project is to identify novel heterocyclic compounds that preferentially bind cerebrovascular amyloid over neutric plaques and explore their feasibility for live imaging for the diagnosis of amyloid deposition in a mouse model of cerebral amyloid angiopathy.

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