PET tracers for cerebrovascular-specific amyloid imaging
American Health Assistance Foundation ADRC
The goal of this project is to identify novel heterocyclic compounds that preferentially bind cerebrovascular amyloid over neuritic plaques and explore their feasibility for live imaging for the diagnosis of amyloid deposition in a mouse model of cerebral amyloid angiopathy.
Mechanisms of amyloid-β-induced vascular smooth muscle cell and cerebral arteriole dysfunction
The major goal of this project is to understand whether CAA is contributing to vascular dysfunction and cognitive dysfunction and the molecular mechanisms underlying CAA-induced cerebrovascular impairment.