Hope Center Members

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Our Team

The diverse laboratories that make up the Hope Center represent scientists and physician scientists on the Medical and Danforth campuses of Washington University.  In addition to the Principal Investigator of each laboratory, there are graduate students, post docs, technicians, and others, more than 500 investigators in total, who ensure that research moves forward.

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  • ances_beau (131x131)

    Beau Ances MD, PhD, MSc

    Associate Professor of Neurology

    Therapeutic Strategies for HIV Associated Neurocognitive Impairment Read More

  • ayala

    Yuna Ayala, PhD

    Assistant Professor of Biochemistry & Molecular Biology, St. Louis University

    Role of RNA processing and TDP-43 function in neurodegeneration Read More

  • Randall Bateman

    Randall Bateman, MD

    Charles F. and Joanne Knight Distinguished Professor of Neurology

    Alzheimer’s Disease: Pathophysiology, biomarkers, predictive diagnostics and treatments Read More

  • bayly_philip

    Philip Bayly, PhD

    Lilyan and E. Lisle Hughes Professor of Mechanical Engineering

    Biomechanical factors in traumatic injury to the brain and spinal cord Read More

  • bieschke (150x150)

    Jan Bieschke, PhD

    Assistant Professor of Biomedical Engineering

    Mechanisms and therapeutic strategies in age-related protein misfolding Read More

  • blumer_kendall

    Kendall Blumer, PhD

    Professor of Cell Biology & Physiology

    Signal transduction in the cardiovascular, nervous and visual systems

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  • brody_david

    David Brody, MD, PhD

    Associate Professor of Neurology

    Translational research in traumatic brain injury Read More

  • Michael_Bruchas (150x150)

    Michael Bruchas, PhD

    Assistant Professor of Anesthesiology

    Genetic, pharmacological, and behavioral dissection of G-protein coupled receptor signal transduction in pain and neuropsychiatric disorders

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  • brunstrom_janice

    Janice Brunstrom-Hernandez, MD

    Associate Professor of Neurology

    Motor disorders arising from injury to the developing brain Read More

  • cairns_nigel

    Nigel Cairns, PhD, FRCPath

    Research Professor of Neurology

    Protein misfolding, inclusion formation and neurodegeneration in Frontotemperal Dementias Read More

  • cao_yuqing

    Yu-Qing Cao, PhD

    Assistant Professor of Anesthesiology

    Voltage-gated calcium channel, synaptic transmission and pathophysiology of migraine headache

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  • Cashikar (150x150)

    Anil Cashikar, PhD

    Research Assistant Professor in Cell Biology & Physiology

    Multivesicular body and ESCRT functions in proteostasis Read More

  • Cavalli (150x150)

    Valeria Cavalli, PhD

    Assistant Professor of Anatomy & Neurobiology

    Molecular, cellular and epigenetic mechanisms regulating axon regeneration Read More

  • chen_zhou-feng

    Zhou-Feng Chen, PhD

    Professor of Anesthesiology

    Molecular and cellular mechanisms of itch sensation

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  • cirrito_john

    John Cirrito, PhD

    Assistant Professor of Neurology

    Relationship between synaptic activity and amyloid-beta metabolism in Alzheimer’s disease Read More

  • corbo_joseph

    Joseph Corbo, MD, PhD

    Associate Professor of Pathology & Immunology

    Transcriptional regulatory networks in photoreceptor development, evolution, and disease Read More

  • cross_anne

    Anne Cross, MD

    Professor of Neurology

    Neuroimmunology related to multiple sclerosis Read More

  • crowder_michael

    Michael Crowder, MD, PhD

    Dr. Seymour and Rose T Brown Professor of Anesthesiology

    Fundamental mechanisms of neuronal cell death following hypoxic injury Read More

  • cruchaga (150x150)

    Carlos Cruchaga, PhD

    Assistant Professor of Psychiatry

    Second-generation sequencing technology to identify rare variants implicated in neurodegenerative diseases Read More

  • dacey_ralph

    Ralph Dacey, MD

    Henry G & Edith Schwartz Professor of Neurological Surgery

    Regulatory mechanisms of the cerebrovascular microcirculation Read More

  • dani_adish

    Adish Dani, PhD

    Research Assistant Professor of Pathology & Immunology

    High-resolution imaging of synaptic architecture and function Read More

  • diamond_marc

    Marc Diamond, MD

    David Clayson Professor of Neurology

    Therapeutic Mechanisms in Human Disease: Polyglutamine Disease Pathogensis and Protein Misfolding in Tauopathy Read More

  • diantonio_aaron

    Aaron DiAntonio, MD, PhD

    Professor of Developmental Biology

    Axonal biology in development and disease Read More

  • dietrich_hans

    Hans Dietrich, PhD

    Assistant Professor of Neurological Surgery

    Regulatory mechanisms of cerebrovascular microcirculation Read More

  • dikranian_krikor

    Krikor Dikranian, MD, PhD

    Associate Professor of Anatomy & Neurobiology

    Neurodegeneration in the developing and mature brain Read More

  • Dorn (150x150) (2)

    Gerald Dorn, MD

    Philip & Sima K Needleman Professor of Medicine

    Pink-parkin signaling and mitochondrial quality control Read More

  • dougherty_joe

    Joseph Dougherty, PhD

    Assistant Professor of Genetics

    Identification of genes and cell types responsible for neurological disorders in humans. Read More

  • evers_alex

    Alex Evers, MD

    Henry E Mallinckrodt Professor of Anesthesiology

    Molecular mechanisms of anesthetics in the nervous system Read More

  • Fagan

    Anne Fagan, PhD

    Research Professor of Neurology

    Cerebrospinal fluid and plasma biomarkers of early stage Alzheimer’s Disease Read More

  • fisher_simon

    Simon Fisher, MD, PhD

    Associate Professor of Medicine

    Role of nutritional and hormonal brain signaling in pathogenesis of obesity, diabetes, and impaired hypoglycemic counterregulation

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  • frieden_carl

    Carl Frieden, PhD

    Professor of Biochemistry & Molecular Biophysics

    Protein folding, structure Read More

  • Gereau

    Robert Gereau, PhD

    Dr. Seymour and Rose T. Brown Professor of Anesthesiology

    Roles of mGluRs in pain plasticity Read More

  • gidday_jeff

    Jeff Gidday, PhD

    Associate Professor of Neurological Surgery

    Identifying endogenous epigenetic mechanisms of neurovascular protection in acute and chronic disease Read More

  • goate_alison

    Alison Goate, DPhil

    Samuel & Mae S Ludwig Professor of Genetics in Psychiatry

    Genetic and genomic approaches to uncovering susceptibility to neurological and psychiatric diseases Read More

  • Gurnett (150x150)

    Christina Gurnett, MD, PhD

    Associate Professor of Neurology

    Genetic basis of epilepsy Read More

  • hallahan_dennis

    Dennis Hallahan, MD

    Elizabeth H and James S McDonnell III Distinguished Professor

    The mechanisms of cell death in normal tissues during cancer therapy Read More

  • han_henry

    Byung-Hee (Henry) Han, PhD

    Assistant Professor of Neurological Surgery

    Mechanisms of CAA-induced cerebrovascular impairment Read More

  • hanson_phyllis

    Phyllis Hanson, MD, PhD

    Professor of Cell Biology & Physiology

    Protein-protein and protein-membrane interactions in neuronal membrane trafficking Read More

  • harms (129x129)

    Matthew Harms, MD

    Assistant Professor of Neurology

    Genetic causes of hereditary neuromuscular diseases Read More

  • admin-ajax (1)

    Charles Harris, MD, PhD

    Assistant Professor of Medicine

    Molecular effects of the glucocorticoid stress hormones Read More

  • Hershey

    Tamara Hershey, PhD

    Professor of Psychiatry

    Clinical and cognitive neuroscience Read More

  • herzog_erik

    Erik Herzog, PhD

    Professor of Biology

    Molecular mechanism of circadian rhythms Read More

  • heuckeroth_robert

    Robert Heuckeroth, MD, PhD

    Alumni Endowed Professor of Pediatrics

    Molecular mechanisms of neuronal development Read More

  • Hodzic

    Didier Hodzic, PhD

    Assistant Professor of Ophthalmology & Visual Sciences

    Role of LINC complexes (Linkers of the Nucleoskeleton to the Cytoskeleton) in nucleokinesis and neuronal migration Read More

  • holtzman_david

    David Holtzman, MD

    Andrew B & Gretchen P Jones Professor of Neurology

    Cellular/Molecular/Biomarker studies of Alzheimer’s Disease and neonatal brain injury Read More

  • shin ichiro

    Shin-ichiro Imai, MD, PhD

    Professor of Developmental Biology

    Understanding the molecular mechanism of aging and longevity in mammals Read More

  • jacquin_mark

    Mark Jacquin, PhD

    Professor of Neurology

    Molecular mechanisms of mammalian sensory system development, plasticity and repair Read More

  • jain_sanjay

    Sanjay Jain, MD, PhD

    Associate Professor of Medicine

    GFL-Ret mediated mechanisms in the development, repair and regeneration of the nervous and urogenital systems Read More

  • johnson_gene

    Eugene Johnson, PhD

    Professor of Neurology

    Biological function and pharmacological potential of GFL neurotrophic factors Read More

  • Karch_small

    Celeste Karch, PhD

    Research Instructor in Psychiatry

    Molecular mechanisms underlying tauopathies Read More

  • Kerschensteiner (150x150)

    Daniel Kerschensteiner, MD

    Assistant Professor of Ophthalmology & Visual Sciences

    Neural circuit assembly and visual processing in the retina Read More

  • kim_albert (150x150)

    Albert Kim, MD, PhD

    Assistant Professor of Neurological Surgery Read More

  • Klein

    Robyn Klein, MD, PhD

    Associate Professor of Medicine

    Cellular and molecular studies of viral and autoimmune encephalitides Read More

  • klyachko_vitaly

    Vitaly Klyachko, PhD

    Assistant Professor of Cell Biology & Physiology

    Understanding the synaptic basis for neural plasticity with the goal of understanding how neural circuits analyze information Read More

  • kotzbauer_paul

    Paul Kotzbauer, MD, PhD

    Assistant Professor of Neurology

    Mechanisms of neurodegeneration in Parkinson’s disease and related disorders Read More

  • Kummer (150x150)

    Terrance Kummer, MD, PhD

    Assistant Professor in Neurology

    Mechanisms of neuronal injury in acute brain trauma Read More

  • lee-jinmoo

    Jin-Moo Lee, MD, PhD

    Professor of Neurology

    Understanding the molecular pathogenesis of spontaneous intracerebral hemorrhage Read More

  • li_mingjie

    Mingjie Li, MD, PhD

    Research Assistant Professor of Neurology

    Developing viral vectors for applications in neuroscience Read More

  • limbrick_david

    David Limbrick, MD, PhD

    Associate Professor of Neurological Surgery

    Neuronal membrane physiology, patch-clamp electrophysiology, CSF proteomics, hydrocephalus, neuroprosthetics, brain tumor biology Read More

  • mackinnon_susan

    Susan Mackinnon, MD

    Sydney M & Robert H Shoenberg Professor of Surgery

    Allograft and the effects of GDNF on Peripheral Nerve Regeneration Read More

  • Moe-cropped-e1377703241760

    Moe Mahjoub, PhD

    Assistant Professor of Medicine

    Mechanisms of cell-cell signaling in normal development and neurodegenerative disease Read More

  • Mecham

    Robert Mecham, PhD

    Alumni Endowed Professor of Cell Biology & Physiology

    Cell-matrix interactions, extracellular matrix and development, vascular development and disease Read More

  • mennerick_steven

    Steven Mennerick, PhD

    Professor of Psychiatry

    Physiology of glutamate and GABA neurotransmission in the CNS Read More

  • milbrandt_jeff

    Jeffrey Milbrandt, MD, PhD

    James S McDonnell Professor of Genetics

    Axonal degeneration, regulation of myelination, neuronal energetics and mitochondrial function in neuropathy and neurodegenerative disease Read More

  • miller_tim

    Timothy Miller, MD, PhD

    Associate Professor of Neurology

    Mechanisms of neurodegeneration and gene targeted therapies in motor neuron diseases Read More

  • monk_kelly

    Kelly Monk, PhD

    Assistant Professor of Developmental Biology

    Molecular mechanisms of myelin formation and repair Read More

  • morris_john

    John Morris, MD

    Harvey A & Dorismae Hacker Friedman Distinguished Professor of Neurology

    Establishing phenotypes for inherited forms of Alzheimer’s disease and other dementias Read More

  • Musiek

    Erik Musiek, MD, PhD

    Assistant Professor of Neurology

    Aging, oxidative stress, and circadian clock genes in neurodegenerative diseases. Read More

  • nerbonne_jeanne (150x150)

    Jeanne Nerbonne, PhD

    Alumni Endowed Professor of Molecular Biology and Pharmacology in Developmental Biology and Internal Medicine

    Molecular mechanisms controlling the regulation and dysregulation of membrane excitability in the cardiovascular and nervous systems Read More

  • o'malley_karen

    Karen O’Malley, PhD

    Professor of Anatomy & Neurobiology

    Mechanisms underlying the specification, regulation and neurodegeneration of dopaminergic and glutamatergic systems Read More

  • ornitz_david

    David Ornitz, MD, PhD

    Alumni Endowed Professor of Developmental Biology

    Neuronal development, regeneration, physiology Read More

  • ory_dan

    Daniel Ory, MD

    Alan A and Edith L Wolff Distinguished Professor of Medicine

    Molecular basis of Niemann-Pick C disease and the regulation of NPC1 and NPC2 genes in cholesterol homeostasis Read More

  • Pappu

    Rohit Pappu, PhD

    Professor of Biomedical Engineering

    Mechanisms of aggregation and neurodegeneration in polyglutamine expansion disorders, specifically Huntington’s disease Read More

  • perlmutter_joel

    Joel Perlmutter, MD

    Elliot Stein Professor of Neurology

    Pharmacology, physiology and pathophysiology of basal ganglia and movement disorders Read More

  • perrin

    Richard Perrin, MD, PhD

    Assistant Professor of Pathology & Immunology

    Novel cerebrospinal fluid biomarkers for early diagnosis, prognosis, and staging of neurodegenerative diseases
    Read More

  • pestronk_alan

    Alan Pestronk, MD

    Professor of Neurology

    Diagnosis, pathogenesis and treatment of immune, hereditary and degenerative neuromuscular disorders Read More

  • Petersen_S (126x126)

    Steve Petersen, PhD

    James S McDonnell Professor of Cognitive Neuroscience

    Behavioral and fMRI studies of attention and cognitive development Read More

  • piccio_laura

    Laura Piccio, MD, PhD

    Research Assistant Professor of Neurology

    Induction and regulation of adaptive autoimmune responses in Multiple Sclerosis Read More

  • raichle (150x149)

    Marcus Raichle, MD

    Professor of Radiology

    Functional brain imaging with positron emission tomography and magnetic resonance Read More

  • Ray (150x150)

    Wilson (Zack) Ray, MD

    Assistant Professor of Neurological Surgery

    Development of innovative technology targeting neuroprosthetic interfaces Read More

  • rubin_josh

    Joshua Rubin, MD, PhD

    Associate Professor of Pediatrics

    Biology and treatment of pediatric brain tumors Read More

  • sakiyama_shelly

    Shelly Sakiyama-Elbert, PhD

    Professor of Biomedical Engineering on the Joseph and Florence Farrow Endowment

    Tissue and cellular engineering approaches to neurological diseases Read More

  • sands_mark

    Mark Sands, PhD

    Professor of Medicine

    Pathophysiology and novel therapies for lysosomal storage diseases Read More

  • schaefer_anneliese

    Anneliese Schaefer, JD, PhD

    Associate Professor of Neurology

    Hope Center Executive Director Read More

  • schlaggar_brad

    Bradley Schlaggar, MD, PhD

    A Ernest & Jane G Stein Professor of Developmental Neurology, in Neurology

    The development and plasticity of human cognition and language Read More

  • schmidt_robert (150x150)

    Robert Schmidt, MD, PhD

    Professor of Pathology & Immunology

    Pathogenetic mechanisms of diabetic and age-related autonomic neuropathy Read More

  • shoykhet

    Michael Shoykhet, MD, PhD

    Instructor in Pediatrics

    Establish mechanistic basis for selective vulnerability of defined neuronal population to hypoxic-ischemic insult Read More

  • snider_joy

    Joy Snider, MD, PhD

    Associate Professor of Neurology

    Mechanisms of protein degradation and intracellular calcium homeostasis in neurodegenerative disorders Read More

  • song_victor

    Sheng-Kwei (Victor) Song, PhD

    Professor of Radiology

    Development of non-invasive imaging of central nervous system white matter Read More

  • admin-ajax5

    William Spees, PhD

    Research Assistant Professor of Radiology

    White-matter diffusion fMRI Read More

  • taghert_paul

    Paul Taghert, PhD

    Professor of Anatomy & Neurobiology

    Circadian neurobiology and developmental neurobiology Read More

  • thio_liulin

    Liu Lin Thio, MD, PhD

    Associate Professor of Neurology

    Glycine receptors in the central nervous system Read More

  • true_heather

    Heather True-Krob, PhD

    Associate Professor of Cell Biology & Physiology

    Protein misfolding and aggregation of prion proteins Read More

  • Urano Pic

    Fumihiko Urano, MD, PhD

    Samuel E Schechter Professor of Medicine

    Patient-based therapeutic development for Wolfram syndrome, the link between endoplasmic reticulum and neurodegeneration Read More

  • Van-Stavern-e1371481970308

    Gregory Van Stavern, MD

    Associate Professor of Ophthalmology & Visual Sciences

    Neuro-inflammation in patients with optic neuritis (ON) affects neuronal activity within visual pathways. Read More

  • Vlassenko (150x150)

    Andrei Vlassenko, MD, PhD

    Research Assistant Professor of Radiology

    Advanced neuroimaging techniques in aging and neurodegenerative disorders Read More

  • wang_lihong

    Lihong Wang, PhD

    Gene K Beare Distinguished Professor of Biomedical Engineering

    Functional and molecular imaging by non-ionizing electromagnetic and ultrasonic waves Read More

  • Yong

    Yong Wang, PhD

    Research Instructor of Radiology

    Developing and applying MRI methods for quantification of pathological changes in neurodegeneration diseases Read More

  • weihl_chris

    Conrad (Chris) Weihl, MD, PhD

    Associate Professor of Neurology

    Protein degradation pathways and their relation to aging, muscle weakness and neurodegeneration Read More

  • wong_michael

    Michael Wong, MD, PhD

    Professor of Neurology

    Cellular mechanisms of epileptogenesis and seizure-induced brain injury Read More

  • wozniak_david

    David Wozniak, PhD

    Research Professor of Psychiatry

    Role of NMDA receptors in neuropathologic changes and cognitive decline Read More

  • wu_greg

    Gregory Wu, MD, PhD

    Assistant Professor of Neurology

    Antigen presentation and inflammation in the central nervous system Read More

  • yamada_kelvin

    Kelvin Yamada, MD

    Professor of Neurology

    Modulation and derangements of synaptic transmission at central nervous system synapses Read More

  • admin-ajax (2)

    Qin Yang, MD, PhD

    Associate Professor of Radiation Oncology

    Understand neural cell reprogramming/regeneration and generate “safe” neural cells for neurological disorder treatment Read More

  • Yano (150x150)

    Hiroko Yano, PhD

    Assistant Professor of Neurological Surgery

    Molecular pathogenesis of neurodegenerative diseases; Epigenetic regulation of gene expression in Huntington’s disease Read More

  • yoo

    Andrew Yoo, PhD

    Assistant Professor of Developmental Biology

    MicroRNA-mediated neuronal reprogramming and chromatin remodeling Read More

  • zhang_weixiong

    Weixiong Zhang, PhD

    Professor of Computer Science & Engineering

    Whole transcriptions modeling and analysis in neurodegenerative diseases Read More

  • zipfel_greg

    Gregory Zipfel, MD

    Associate Professor of Neurological Surgery

    Role of cerebral amyloid angiopathy on cerebral blood flow, cerebral ischemia, cerebral hemorrhage, and dementia; Pathophysiology and novel therapeutic approaches for aneurysmal subarachnoid hemorrhage Read More

  • zorumski_charles

    Charles Zorumski, MD

    Samuel B Guze Professor of Psychiatry

    Modulation of excitatory and inhibitory synaptic transmission Read More