Publications

The latest published manuscripts from Hope Center investigators. Click on titles to learn more. Read More

The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk

Posted on August 21, 2019

Yuetiva Deming, Fabia Filipello, Francesca Cignarella, Claudia Cantoni, Simon Hsu, Robert Mikesell, Zeran Li, Jorge L Del-Aguila, Umber Dube, Fabiana Geraldo Farias, Joseph Bradley, John Budde, Laura Ibanez, Maria Victoria Fernandez, Kaj Blennow, Henrik Zetterberg, Amanda Heslegrave, Per M Johansson, Johan Svensson, Bengt Nellgård, Alberto Lleo, Daniel Alcolea, Jordi Clarimon, Lorena Rami, José Luis Molinuevo, Marc Suárez-Calvet, Estrella Morenas-Rodríguez, Gernot Kleinberger, Michael Ewers, Oscar Harari, Christian Haass, Thomas J Brett, Bruno A. Benitez, Celeste M. Karch, Laura Piccio and Carlos Cruchaga. Science Translational Medicine, Vol 11, Issue 505,14 August 2019 Read More

Posted in: Axon Injury & Repair, HPAN, Lysosome, Neurodegeneration, Neurogenetics & Transcriptomics, Publications Faculty: , , , ,

High-precision plasma β-amyloid 42/40 predicts current and future brain amyloidosis

Posted on August 5, 2019

Suzanne E. Schindler, James G. Bollinger, Vitaliy Ovod, Kwasi G. Mawuenyega, Yan Li, Brian A. Gordon, David M. Holtzman, John C. Morris, Tammie L.S. Benzinger, Chengjie Xiong, Anne M. Fagan, Randall J. Bateman. Neurology 2019 Read More

Posted in: HPAN, Neurodegeneration, Neurogenetics & Transcriptomics, Publications Faculty: , , , ,

Desmin forms toxic, seeding-competent amyloid aggregates that persist in muscle fibers

Posted on August 2, 2019

Niraja Kedia, Khalid Arhzaouy, Sara K. Pittman, Yuanzi Sun, Mark Batchelor, Conrad C. Weihl, and Jan Bieschke. PNAS first published August 1, 2019 Read More

Posted in: HPAN, Neurodegeneration, Pilot Projects, Publications Faculty:

Altered neuropsychological performance and reduced brain volumetrics in people living with HIV on integrase strand transfer inhibitors

Posted on July 31, 2019

Jane O’Halloran, Sarah Cooley, Jeremy Strain, Anna Boerwinkle, Robert Paul, Rachel Presti, Beau Ances. AIDS (London, England), Volume 33, Issue 9, 15 July 2019, Pages 1477-1483 Read More

Posted in: HPAN, Neurodegeneration, Publications Faculty:

CRTAM protects against intestinal dysbiosis during pathogenic parasitic infection by enabling Th17 maturation

Posted on July 27, 2019

Luisa Cervantes-Barragan, Victor S. Cortez, Qiuling Wang, Keely G. McDonald, Jiani N. Chai, Blanda Di Luccia, Susan Gilfillan, Chyi-Song Hsieh, Rodney D. Newberry, L. David Sibley and Marco Colonna. Frontiers in Immunology, Volume 10, Issue JUL, 2019, Article number 1423 Read More

Posted in: HPAN, Neurodegeneration, Neurogenetics & Transcriptomics, Publications Faculty: