Publications

The latest published manuscripts from Hope Center investigators. Click on titles to learn more. Read More

Simple nutrients bypass the requirement for HLH-30 in coupling lysosomal nutrient sensing to survival

Posted on June 11, 2019

John T. Murphy , Haiyan Liu , Xiucui Ma, Alex Shaver, Brian M. Egan, Clara Oh, Alexander Boyko, Travis Mazer, Samuel Ang, Rohan Khopkar, Ali Javaheri, Sandeep Kumar, Xuntian Jiang, Daniel Ory, Kartik Mani, Scot J. Matkovich, Kerry Kornfeld , Abhinav Diwan. PLoS biology, Volume 17, Issue 5, 1 May 2019, Page e3000245 Read More

Posted in: HPAN, Lysosome, Neurodegeneration, Publications Faculty:

Sphingosine-1-phosphate receptor 1 activation in astrocytes contributes to neuropathic pain

Posted on June 10, 2019

Zhoumou Chen, Timothy M. Doyle, Livio Luongo, Tally M. Largent-Milnes, Luigino Antonio Giancotti, Grant Kolar, Silvia Squillace, Serena Boccella, John K. Walker, Alexander Pendleton, Sarah Spiegel, William L. Neumann, Todd W. Vanderah, and Daniela Salvemini. Proceedings of the National Academy of Sciences of the United States of America, Volume 116, Issue 21, 2019, Pages 10557-10562 Read More

Posted in: Publications Faculty:

Fat-Produced Adipsin Regulates Inflammatory Arthritis

Posted on June 10, 2019

Yongjia Li, Wei Zou, Jonathan R. Brestoff, Nidhi Rohatgi, Xiaobo Wu, John P. Atkinson, Charles A. Harris, Steven L. Teitelbaum. Cell Reports, Volume 27, Issue 10, 4 June 2019, Pages 2809-2816.e3 Read More

Posted in: Neurogenetics & Transcriptomics, Neurovascular Injury & Repair, Publications Faculty: ,

miRNA contributions to pediatric-onset multiple sclerosis inferred from GWAS

Posted on June 7, 2019

Brooke Rhead, Xiaorong Shao, Jennifer S. Graves, Tanuja Chitnis, Amy T. Waldman, Timothy Lotze, Teri Schreiner, Anita Belman, Lauren Krupp, Benjamin M. Greenberg, Bianca Weinstock–Guttman, Gregory Aaen, Jan M. Tillema, Moses Rodriguez, Janace Hart, Stacy Caillier, Jayne Ness, Yolanda Harris, Jennifer Rubin, Meghan S. Candee, Mark Gorman, Leslie Benson, Soe Mar, Ilana Kahn, John Rose, T. Charles Casper, Hong Quach, Diana Quach, Catherine Schaefer, Emmanuelle Waubant, Lisa F. Barcellos on behalf of the US Network of Pediatric MS Centers. Annals of Clinical and Translational Neurology 2019 Read More

Posted in: HPAN, Neurodegeneration, Neurogenetics & Transcriptomics, Publications Faculty:

Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression

Posted on June 5, 2019

Filip Liebsch, Luka Kulic, Charlotte Teunissen, Adeola Shobo, Irem Ulku, Vivienne Engelschalt, Mark A. Hancock, Wiesje M. van der Flier, Peter Kunach, Pedro Rosa-Neto, Philip Scheltens, Judes Poirier, Paul Saftig, Randall J. Bateman, John Breitner, Christoph Hock & Gerhard Multhaup. Nature Communications, Volume 10, Issue 1, 1 December 2019, Article number 2240 Read More

Posted in: HPAN, Neurodegeneration, Neurogenetics & Transcriptomics, Publications Faculty: