Principal Investigator: David Brody, MD, PhD (WUSTL Neurology)
Co-investigators: Alexander Parsadanian, PhD (WUSTL Neurology), Philip Bayly, PhD (WUSTL Mechanical Engineering), Krikor Dikranian, MD, PhD (WUSTL Anatomy & Neurobiology)
The human brain undergoes substantial growth and development during the first two years of life. Traumatic brain injury (TBI) during this window is a leading cause of death and disability, and can cause profound alterations of the brain including cognitive dysfunction, attention deficit, hyperactivity and impairment in emotional regulation and judgment. There currently are no effective treatments for TBI other than supportive care, and relatively little research focuses on pediatric TBI compared to other problems of comparable importance. To better understand how infant TBI leads to these behavioral changes, this research project will develop and characterize a clinically relevant mouse model.