Development of a Clinically Relevant Mouse Model of Infant Traumatic Brain Injury

2007 Pilot Project Read More

Investigators

Principal Investigator: David Brody, MD, PhD (WashU Neurology)
Co-investigators: Alexander Parsadanian, PhD (WashU Neurology), Philip Bayly, PhD (WashU Mechanical Engineering), Krikor Dikranian, MD, PhD (WashU  Neuroscience)

Description

The human brain undergoes substantial growth and development during the first two years of life. Traumatic brain injury (TBI) during this window is a leading cause of death and disability, and can cause profound alterations of the brain including cognitive dysfunction, attention deficit, hyperactivity and impairment in emotional regulation and judgment. There currently are no effective treatments for TBI other than supportive care, and relatively little research focuses on pediatric TBI compared to other problems of comparable importance. To better understand how infant TBI leads to these behavioral changes, this research project will develop and characterize a clinically relevant mouse model.

Funded Grants

“Stereotaxic Accessory for Reproducible Neurotrauma”
NIH/NINDS (SBIR Phase II R44 NS46825 – Scouten (PI, Bayly on subcontract to myNeuroLab.com)     9/30/06 – 8/31/08

“Amyloid-β and traumatic brain injury in children”
Thrasher Research Fund (PI, Brody)    1/1/06 – 12/31/08

“Combined Magnetic Resonance Elastography and Diffusion Tensor Imaging of the Brain”
Naval Research Laboratory N00173-14-P-3472, N00173-15-P-6401, N0001417P7002
(PIs, Phil Bayly and Anthony Romano, Co-I: Brody)     10/1/14 – 9/30/17

“In Vivo Measurement of Brain Biomechanics” 
NIH/NINDS R01 NS055951 (PI, Bayly)     7/1/07 – 11/30/17

“Mechanisms Underlying Amyloid-beta and Tau Pathologies Following Traumatic Brain Injury”
NIH/NINDS R01 NS065069-07 (PI, Brody)     7/1/09-6/30/18

 

Publications

Mac Donald CL, Dikranian K, Bayly P, Holtzman D, Brody D. Diffusion tensor imaging reliably detects experimental traumatic axonal injury and indicates approximate time of injury. J Neurosci.;27(44):11869-76, (2007)

Brody DL, Mac Donald C, Kessens CC, Yuede C, Parsadanian M, Spinner M, Kim E, Schwetye KE, Holtzman DM, Bayly PV. Electromagnetic controlled cortical impact device for precise, graded experimental traumatic brain injury. J Neurotrauma;24(4):657-73, (2007).

Mac Donald CL, Dikranian K, Song SK, Bayly PV, Holtzman DM, Brody DL. Detection of traumatic axonal injury with diffusion tensor imaging in a mouse model of traumatic brain injury. Exp Neurol. ;205(1):116-31, (2007).

Dikranian K, Cohen R, Mac Donald C, Pan Y, Brakefield D, Bayly P. Parsadanian Mild traumatic brain injury to the infant mouse causes robust white matter axonal degeneration which precedes apoptotic death of cortical and thalamic neurons. Exp Neurol.;211(2):551-60, (2008).

Shitaka Y, Tran HT, Bennett RE, Sanchez L, Levy MA, Dikranian K, Brody DL. Repetitive closed-skull traumatic brain injury in mice causes persistent multifocal axonal injury and microglial reactivity. J Neuropathol Exp Neurol.;70(7):551-67, (2011).

Updated July 2017

Hope Center Investigators

Krikor Dikranian

Philip Bayly

David Brody