In vivo labeled proteomics in human CSF

2006 Pilot Project Read More

Investigators

Principal Investigator: Randall Bateman, MD (WUSTL Neurology)
Co-investigators: Donald Elbert, PhD (WUSTL Biomedical Engineering), Alison Goate, DPhil (WUSTL Psychiatry)

Description

Dr. Randy Bateman is a new faculty member of the Hope Center. A neurology physician-scientist working in Dr. David Holtzman’s laboratory, Dr. Bateman developed a new method for measuring the production of brain proteins by sensitive measurement from human cerebrospinal fluid. This technique has been used for pioneering studies of Alzheimer’s Disease and now offers potential for use in early diagnosis and treatment of a range of important neurological conditions.

Funded Grants

FACS study was awarded a supplemental grant from Specific Aim 1

Publications

Elbert DL, Mawuenyega KG, Scott EA, Wildsmith KR, Bateman RJ. Stable isotope labeling tandem mass spectrometry (SILT): integration with peptide identification and extension to data-dependent scans. J Proteome Res (2008).

Intellectual Property

SILTmass program

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Hope Center Investigators

Randall Bateman

Alison Goate