Citalopram Decreases ABeta Plaque Accumulation in APP Mice and CSF ABeta in Humans

2010 Pilot Project Read More

Investigators

Principal Investigator: Yvette Sheline, MD (WUSTL Psychiatry)
Co-investigators: Jin-Moo Lee, MD, PhD (WUSTL Neurology), Robert Swarm, MD (WUSTL Anesthesiology)

Description

The investigators will conduct two studies in parallel: a mouse study to determine the longitudinal growth of amyloid plaques in transgenic mice and a human study to determine the acute effects of antidepressants in human CSF. Dr. Sheline and her co-investigators have demonstrated that antidepressants lower amyloid production in mouse brain in transgenic mice. They now extend the study to determine the effect on amyloid plaque accumulation. In addition they will gather preliminary data on antidepressant effects on human CSF amyloid, a marker of Alzheimer’s disease.

Funded Grants

“Citalopram Decreases Amyloid-B Synthesis in Human CSF”
NIH-NINDS, R21AG0390690-01A1 (Sheline, PI)
This project will determine whether compared to placebo, SSRI antidepressants lower the production of Aβ in human CSF.

“Citalopram decreases CSF Aβ: a randomized dose finding trial”
NIH-NINDS, R01AG041502-01A1 (Sheline, PI)

“Synaptic regulation of ERK-mediated amyloid-β metabolism”
NIH-NINDS, R01AG042513 (Cirrito, PI)

Publications

Cirrito JR, DiSabato BM, Restivo JL, Verges DK, Goebel WD, Sathyan A, Hayreh D, D’Angelo G, Benzinger T, Yoon H, Kim J, Morris JC, Mintun MA, Sheline YI. Serotonin signaling is associated with lower amyloid-beta levels and plaques in transgenic mice and humans. PNAS, 108:14968-73 (2011).

 

Updated 10/31/2012

EmailPrintShare

Hope Center Investigators

Yvette Sheline

Jin-Moo Lee

Support

This pilot is made possible by a generous gift from Doug and Vicki Hill, and the Danforth Foundation Challenge.

Danforth Challenge