HPAN Faculty
Each faculty member of the Hope Center Program on Protein Aggregation & Neurodegeneration (HPAN) has an active research program and/or collaboration to investigate the role of protein aggregation in neurodegenerative disease. In addition, HPAN was chosen by the Dean to be a BioMed 21 Interdisciplinary Research Center, with an award of space in the new BJC Institute of Health and a financial commitment.
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Beau Ances MD, PhD, MSc
Daniel J. Brennan, MD Professor of Neurology
Therapeutic Strategies for HIV Associated Neurocognitive Impairment Read More
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Ghazal Ashrafi, PhD
Assistant Professor of Cell Biology & Physiology
Metabolic regulation of neurotransmission Read More
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Yuna Ayala, PhD
Assistant Professor of Biochemistry & Molecular Biology, Saint Louis University
Role of RNA processing and TDP-43 function in neurodegeneration Read More
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Randall Bateman, MD
Charles F. and Joanne Knight Distinguished Professor of Neurology
Alzheimer’s Disease: Pathophysiology, biomarkers, predictive diagnostics and treatments Read More
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Bruno Benítez, MD
Assistant Professor of Psychiatry
Integration of phenotypic data with genomic, transcriptomic and proteomic data of individuals with neurodegenerative diseases Read More
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Kendall Blumer, PhD
Professor of Cell Biology & Physiology
Signal transduction in the cardiovascular, nervous and visual systems
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Thomas Brett, PhD
Associate Professor of Medicine
Investigate the molecular mechanisms of inflammatory signaling in diseases hallmarked by chronic inflammation Read More
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Thomas Burris, PhD
Alumni Endowed Professor, University of Health Sciences & Pharmacy
Pharmacology and chemical biology of nuclear receptors (NRs) Read More
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Anil Cashikar, PhD
Assistant Professor of Psychiatry
Oxysterols in Alzheimer’s disease Read More
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Zhou-Feng Chen, PhD
Russell D. and Mary B. Shelden Professor of Anesthesiology
Molecular and cellular mechanisms of itch sensation
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John Cirrito, PhD
Associate Professor of Neurology
Relationship between synaptic activity and amyloid-beta metabolism in Alzheimer’s disease Read More
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Marco Colonna, MD
Robert Rock Belliveau MD Professor of Pathology and Immunology
Innate immune responses in neurodegeneration Read More
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Carlos Cruchaga, PhD
Professor of Psychiatry
Genetic and multi-omic approaches to identify novel variants, genes and pathways implicated on neurodegeneration, with the ultimate goal of understanding the biology of neurodegenerative diseases Read More
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Albert (Gus) Davis, MD, PhD
Assistant Professor of Neurology
Understanding the molecular and cellular mechanisms of protein aggregation and neurodegeneration in Parkinson disease and dementia with Lewy bodies Read More
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Marc Diamond, MD
Adjunct Professor of Neurology
Therapeutic Mechanisms in Human Disease: Polyglutamine Disease Pathogensis and Protein Misfolding in Tauopathy Read More
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Abhinav Diwan, MD
Associate Professor of Medicine
Regulation of Lysosome function in Cellular Physiology and Pathology Read More
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Anne Fagan, PhD
Professor of Neurology
Cerebrospinal fluid and plasma biomarkers of early stage Alzheimer’s Disease Read More
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Carl Frieden, PhD
Professor of Biochemistry & Molecular Biophysics
Protein folding, structure Read More
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Gilbert Gallardo, PhD
Assistant Professor of Neurology
Discovering mechanisms of neurodegeneration for potential therapeutic intervention Read More
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Brian Gordon, PhD
Assistant Professor of Radiology
Using in vivo neuroimaging and biofluid measurements in humans to better understand the pathophysiology of Alzheimer disease Read More
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Dennis Hallahan, MD
Elizabeth H and James S McDonnell III Distinguished Professor of Medicine
The mechanisms of cell death in normal tissues during cancer therapy Read More
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Edward Han, PhD
Assistant Professor of Neuroscience
Identifying the role of neurotoxic protein aggregates on neuronal network activity and cell health using in vivo imaging Read More
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Tamara Hershey, PhD
Professor of Psychiatry
Clinical and cognitive neuroscience Read More
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David Holtzman, MD
Andrew B & Gretchen P Jones Professor of Neurology
Cellular/Molecular/Biomarker studies of Alzheimer’s Disease and neonatal brain injury Read More
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Meredith Jackrel, PhD
Assistant Professor of Chemistry
Engineering and applying protein-remodeling factors to counter neurodegenerative disease Read More
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Sanjay Jain, MD, PhD
Associate Professor of Medicine
GFL-Ret mediated mechanisms in the development, repair and regeneration of the nervous and urogenital systems Read More
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Celeste Karch, PhD
Associate Professor of Psychiatry
Molecular mechanisms underlying tauopathies Read More
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Paul Kotzbauer, MD, PhD
Professor of Neurology
Mechanisms of neurodegeneration in Parkinson’s disease and related disorders Read More
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Alexxai Kravitz, PhD
Associate Professor of Psychiatry
Basal ganglia contributions to movement Read More
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Geraldine Kress, PhD
Assistant Professor of Neurology
Role of circadian function on memory during aging and Alzheimer’s disease (AD) progression Read More
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Jin-Moo Lee, MD, PhD
Norman J. Stupp Professor of Neurology
Understanding Mechanisms of Neurologic Disease Read More
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Mingjie Li, MD, PhD
Associate Professor of Neurology
Developing viral vectors for applications in neuroscience Read More
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David Limbrick, MD, PhD
Professor of Neurosurgery
Neuronal membrane physiology, patch-clamp electrophysiology, CSF proteomics, hydrocephalus, neuroprosthetics, brain tumor biology Read More
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Brendan Lucey, MD
Associate Professor of Neurology
Understanding the relationship between sleep, the amyloid beta diurnal pattern, and Alzheimer’s disease Read More
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Moe Mahjoub, PhD
Associate Professor of Medicine
Mechanisms of cell-cell signaling in normal development and neurodegenerative disease Read More
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Soe Soe Mar, MD
Professor of Neurology
Pediatric multiple sclerosis and other white matter diseases, and pediatric migraine Read More
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Helen McNeill, PhD
BJC Investigator, Larry J. Shapiro and Carol-Ann Uetake-Shapiro Professor of Developmental Biology
Understanding how Fat cadherins and the Hippo pathway regulate growth and patterning Read More
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Steven Mennerick, PhD
John P. Feighner Professor of Psychiatry
Physiology of glutamate and GABA neurotransmission in the CNS Read More
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Timothy Miller, MD, PhD
David Clayson Professor of Neurology
New, effective, and safe treatments for neurodegenerative diseases Read More
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Liviu Mirica, PhD
William H. and Janet G. Lycan Professor of Chemistry, University of Illinois
Development of therapeutic and imaging chemical agents for Alzheimer’s disease; Design of specific inhibitors of histone demethylases Read More
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John Morris, MD
Harvey A & Dorismae Hacker Friedman Distinguished Professor of Neurology
Establishing phenotypes for inherited forms of Alzheimer’s disease and other dementias Read More
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Erik Musiek, MD, PhD
Associate Professor of Neurology
Aging, oxidative stress, and circadian clock genes in neurodegenerative diseases Read More
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Andrew Nguyen, PhD
Assistant Professor of Medicine, Saint Louis University
Strategies for increasing progranulin levels as potential therapies for progranulin-deficient FTD Read More
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David Ornitz, MD, PhD
Alumni Endowed Professor of Developmental Biology
Neuronal development, regeneration, physiology Read More
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Rohit Pappu, PhD
Edwin H. Murty Professor of Engineering
Mechanisms of aggregation and neurodegeneration in polyglutamine expansion disorders, specifically Huntington’s disease Read More
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Steven Paul, MD
Professor of Psychiatry
Understanding how apoE contributes to the clearance and metabolism of Aβ in Alzheimer’s disease Read More
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David Perlmutter, MD
Professor of Pediatrics, Executive Vice Chancellor for Medical Affairs and Dean
Cellular mechanisms to clear misfolded proteins, and therapies to minimize toxicity by stimulating degradation of misfolded proteins Read More
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Joel Perlmutter, MD
Elliot Stein Professor of Neurology
Pharmacology, physiology and pathophysiology of basal ganglia and movement disorders Read More
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Richard Perrin, MD, PhD
Assistant Professor of Pathology & Immunology
Novel cerebrospinal fluid biomarkers for early diagnosis, prognosis, and staging of neurodegenerative diseases
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Alan Pestronk, MD
Professor of Neurology
Diagnosis, pathogenesis and treatment of immune, hereditary and degenerative neuromuscular disorders Read More
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Steve Petersen, PhD
James S McDonnell Professor of Cognitive Neuroscience
Behavioral and fMRI studies of attention and cognitive development Read More
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Marcus Raichle, MD
Alan A. and Edith L. Wolff Distinguished Professor of Medicine
Functional brain imaging with positron emission tomography and magnetic resonance Read More
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Mark Sands, PhD
Professor of Medicine
Pathophysiology and novel therapies for lysosomal storage diseases Read More
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Robert Schmidt, MD, PhD
Professor of Pathology & Immunology
Pathogenetic mechanisms of diabetic and age-related autonomic neuropathy Read More
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Joy Snider, MD, PhD
Professor of Neurology
Mechanisms of protein degradation and intracellular calcium homeostasis in neurodegenerative disorders Read More
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Amber Stratman, PhD
Assistant Professor of Cell Biology & Physiology
Mechanisms regulating blood vessel formation, stabilization, and blood flow sensing during development and disease Read More
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Heather True, PhD
Professor of Cell Biology & Physiology
Protein misfolding and aggregation of prion proteins Read More
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Fumihiko Urano, MD, PhD
Samuel E Schechter Professor of Medicine
Patient-based therapeutic development for Wolfram syndrome, the link between endoplasmic reticulum and neurodegeneration Read More
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Andrei Vlassenko, MD, PhD
Associate Professor of Radiology
Advanced neuroimaging techniques in aging and neurodegenerative disorders Read More
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Yong Wang, PhD
Assistant Professor of Obstetrics & Gynecology
Developing and applying MRI methods for quantification of pathological changes in neurodegeneration diseases Read More
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Conrad (Chris) Weihl, MD, PhD
Professor of Neurology
Protein degradation pathways and their relation to aging, muscle weakness and neurodegeneration Read More
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David Wozniak, PhD
Professor of Psychiatry
Role of NMDA receptors in neuropathologic changes and cognitive decline Read More
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Qin Yang, MD, PhD
Associate Professor of Radiation Oncology
Understand neural cell reprogramming/regeneration and generate “safe” neural cells for neurological disorder treatment Read More
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Hiroko Yano, PhD
Associate Professor of Neurosurgery
Molecular pathogenesis of neurodegenerative diseases; Epigenetic regulation of gene expression in Huntington’s disease Read More
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Andrew Yoo, PhD
Associate Professor of Developmental Biology
MicroRNA-mediated neuronal reprogramming and chromatin remodeling Read More
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Gregory Zipfel, MD
Ralph G. Dacey Distinguished Professor of Neurological Surgery
Role of cerebral amyloid angiopathy on cerebral blood flow, cerebral ischemia, cerebral hemorrhage, and dementia; Pathophysiology and novel therapeutic approaches for aneurysmal subarachnoid hemorrhage Read More