HPAN Labs

HPAN Faculty

Each faculty member of the Hope Center Program on Protein Aggregation & Neurodegeneration (HPAN) has an active research program and/or collaboration to investigate the role of protein aggregation in neurodegenerative disease.  In addition, HPAN was chosen by the Dean to be a BioMed 21 Interdisciplinary Research Center, with an award of space in the new BJC Institute of Health and a financial commitment.

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  Beau Ances MD, PhD, MSc

  Associate Professor of Neurology

  Therapeutic Strategies for HIV Associated Neurocognitive Impairment Read More

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  Yuna Ayala, PhD

  Assistant Professor of Biochemistry & Molecular Biology, St. Louis University

  Role of RNA processing and TDP-43 function in neurodegeneration Read More

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  Randall Bateman, MD

  Charles F. and Joanne Knight Distinguished Professor of Neurology

  Alzheimer’s Disease: Pathophysiology, biomarkers, predictive diagnostics and treatments Read More

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  Jan Bieschke, PhD

  Assistant Professor of Biomedical Engineering

  Mechanisms and therapeutic strategies in age-related protein misfolding Read More

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  Kendall Blumer, PhD

  Professor of Cell Biology & Physiology

  Signal transduction in the cardiovascular, nervous and visual systems

  Read More

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  David Brody, MD, PhD

  Associate Professor of Neurology

  Translational research in traumatic brain injury Read More

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  Nigel Cairns, PhD, FRCPath

  Professor of Neurology

  Protein misfolding, inclusion formation and neurodegeneration in Frontotemperal Dementias Read More

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  Anil Cashikar, PhD

  Assistant Professor in Cell Biology & Physiology

  Multivesicular body and ESCRT functions in proteostasis Read More

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  Zhou-Feng Chen, PhD

  Professor of Anesthesiology

  Molecular and cellular mechanisms of itch sensation

  Read More

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  John Cirrito, PhD

  Assistant Professor of Neurology

  Relationship between synaptic activity and amyloid-beta metabolism in Alzheimer’s disease Read More

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  Carlos Cruchaga, PhD

  Assistant Professor of Psychiatry

  Second-generation sequencing technology to identify rare variants implicated in neurodegenerative diseases Read More

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  Adish Dani, PhD

  Assistant Professor of Pathology & Immunology

  High-resolution imaging of synaptic architecture and function Read More

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  Marc Diamond, MD

  Adjunct Professor at Washington University, Professor of Neurology & Neurotherapeutics, UT Southwestern Medical Center

  Therapeutic Mechanisms in Human Disease: Polyglutamine Disease Pathogensis and Protein Misfolding in Tauopathy Read More

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  Abhinav Diwan, MD

  Assistant Professor of Medicine

  Regulation of Lysosome function in Cellular Physiology and Pathology Read More

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  Anne Fagan, PhD

  Professor of Neurology

  Cerebrospinal fluid and plasma biomarkers of early stage Alzheimer’s Disease Read More

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  Carl Frieden, PhD

  Professor of Biochemistry & Molecular Biophysics

  Protein folding, structure Read More

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  Jeff Gidday, PhD

  Associate Professor of Neurological Surgery

  Identifying endogenous epigenetic mechanisms of neurovascular protection in acute and chronic disease Read More

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  Alison Goate, DPhil

  Director, Center on Alzheimer’s Disease
  Icahn School of Medicine at Mount Sinai

  Genetic and genomic approaches to uncovering susceptibility to neurological and psychiatric diseases Read More

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  Dennis Hallahan, MD

  Elizabeth H and James S McDonnell III Distinguished Professor of Medicine

  The mechanisms of cell death in normal tissues during cancer therapy Read More

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  Byung-Hee (Henry) Han, PhD

  Assistant Professor of Neurological Surgery

  Mechanisms of CAA-induced cerebrovascular impairment Read More

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  Phyllis Hanson, MD, PhD

  Professor of Cell Biology & Physiology

  Protein-protein and protein-membrane interactions in neuronal membrane trafficking Read More

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  Matthew Harms, MD

  Assistant Professor of Neurology

  Genetic causes of hereditary neuromuscular diseases Read More

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  Tamara Hershey, PhD

  Professor of Psychiatry

  Clinical and cognitive neuroscience Read More

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  Didier Hodzic, PhD

  Assistant Professor of Ophthalmology & Visual Sciences

  Role of LINC complexes (Linkers of the Nucleoskeleton to the Cytoskeleton) in nucleokinesis and neuronal migration Read More

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  David Holtzman, MD

  Andrew B & Gretchen P Jones Professor of Neurology

  Cellular/Molecular/Biomarker studies of Alzheimer’s Disease and neonatal brain injury Read More

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  Sanjay Jain, MD, PhD

  Associate Professor of Medicine

  GFL-Ret mediated mechanisms in the development, repair and regeneration of the nervous and urogenital systems Read More

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  Celeste Karch, PhD

  Assistant Professor of Psychiatry

  Molecular mechanisms underlying tauopathies Read More

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  Paul Kotzbauer, MD, PhD

  Associate Professor of Neurology

  Mechanisms of neurodegeneration in Parkinson’s disease and related disorders Read More

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  Jin-Moo Lee, MD, PhD

  Professor of Neurology

  Understanding the molecular pathogenesis of spontaneous intracerebral hemorrhage Read More

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  Mingjie Li, MD, PhD

  Assistant Professor of Neurology

  Developing viral vectors for applications in neuroscience Read More

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  David Limbrick, MD, PhD

  Associate Professor of Neurological Surgery

  Neuronal membrane physiology, patch-clamp electrophysiology, CSF proteomics, hydrocephalus, neuroprosthetics, brain tumor biology Read More

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  Brendan Lucey, MD

  Assistant Professor of Neurology

  Understanding the relationship between sleep, the amyloid beta diurnal pattern, and Alzheimer’s disease. Read More

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  Moe Mahjoub, PhD

  Assistant Professor of Medicine

  Mechanisms of cell-cell signaling in normal development and neurodegenerative disease Read More

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  Soe Soe Mar, MD

  Associate Professor of Neurology

  Pediatric multiple sclerosis and other white matter diseases, and pediatric migraine. Read More

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  Steven Mennerick, PhD

  Professor of Psychiatry

  Physiology of glutamate and GABA neurotransmission in the CNS Read More

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  Timothy Miller, MD, PhD

  Associate Professor of Neurology

  Mechanisms of neurodegeneration and gene targeted therapies in motor neuron diseases Read More

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  John Morris, MD

  Harvey A & Dorismae Hacker Friedman Distinguished Professor of Neurology

  Establishing phenotypes for inherited forms of Alzheimer’s disease and other dementias Read More

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  Erik Musiek, MD, PhD

  Assistant Professor of Neurology

  Aging, oxidative stress, and circadian clock genes in neurodegenerative diseases. Read More

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  David Ornitz, MD, PhD

  Alumni Endowed Professor of Developmental Biology

  Neuronal development, regeneration, physiology Read More

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  Daniel Ory, MD

  Alan A and Edith L Wolff Distinguished Professor of Medicine

  Molecular basis of Niemann-Pick C disease and the regulation of NPC1 and NPC2 genes in cholesterol homeostasis Read More

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  Rohit Pappu, PhD

  Professor of Biomedical Engineering

  Mechanisms of aggregation and neurodegeneration in polyglutamine expansion disorders, specifically Huntington’s disease Read More

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  Joel Perlmutter, MD

  Elliot Stein Professor of Neurology

  Pharmacology, physiology and pathophysiology of basal ganglia and movement disorders Read More

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  Richard Perrin, MD, PhD

  Assistant Professor of Pathology & Immunology

  Novel cerebrospinal fluid biomarkers for early diagnosis, prognosis, and staging of neurodegenerative diseases
  Read More

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  Alan Pestronk, MD

  Professor of Neurology

  Diagnosis, pathogenesis and treatment of immune, hereditary and degenerative neuromuscular disorders Read More

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  Steve Petersen, PhD

  James S McDonnell Professor of Cognitive Neuroscience

  Behavioral and fMRI studies of attention and cognitive development Read More

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  Marcus Raichle, MD

  Alan A. and Edith L. Wolff Distinguished Professor of Medicine

  Functional brain imaging with positron emission tomography and magnetic resonance Read More

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  Mark Sands, PhD

  Professor of Medicine

  Pathophysiology and novel therapies for lysosomal storage diseases Read More

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  Robert Schmidt, MD, PhD

  Professor of Pathology & Immunology

  Pathogenetic mechanisms of diabetic and age-related autonomic neuropathy Read More

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  Joy Snider, MD, PhD

  Associate Professor of Neurology

  Mechanisms of protein degradation and intracellular calcium homeostasis in neurodegenerative disorders Read More

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  Heather True-Krob, PhD

  Associate Professor of Cell Biology & Physiology

  Protein misfolding and aggregation of prion proteins Read More

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  Fumihiko Urano, MD, PhD

  Samuel E Schechter Professor of Medicine

  Patient-based therapeutic development for Wolfram syndrome, the link between endoplasmic reticulum and neurodegeneration Read More

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  Andrei Vlassenko, MD, PhD

  Assistant Professor of Radiology

  Advanced neuroimaging techniques in aging and neurodegenerative disorders Read More

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  Yong Wang, PhD

  Instructor of Radiology

  Developing and applying MRI methods for quantification of pathological changes in neurodegeneration diseases Read More

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  Conrad (Chris) Weihl, MD, PhD

  Associate Professor of Neurology

  Protein degradation pathways and their relation to aging, muscle weakness and neurodegeneration Read More

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  David Wozniak, PhD

  Research Professor of Psychiatry

  Role of NMDA receptors in neuropathologic changes and cognitive decline Read More

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  Qin Yang, MD, PhD

  Associate Professor of Radiation Oncology

  Understand neural cell reprogramming/regeneration and generate “safe” neural cells for neurological disorder treatment Read More

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  Hiroko Yano, PhD

  Assistant Professor of Neurological Surgery

  Molecular pathogenesis of neurodegenerative diseases; Epigenetic regulation of gene expression in Huntington’s disease Read More

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  Andrew Yoo, PhD

  Assistant Professor of Developmental Biology

  MicroRNA-mediated neuronal reprogramming and chromatin remodeling Read More

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  Gregory Zipfel, MD

  Associate Professor of Neurological Surgery

  Role of cerebral amyloid angiopathy on cerebral blood flow, cerebral ischemia, cerebral hemorrhage, and dementia; Pathophysiology and novel therapeutic approaches for aneurysmal subarachnoid hemorrhage Read More