Representing fourteen academic departments and both campuses of Washington University Read More

HPAN Faculty

Each faculty member of the Hope Center Program on Protein Aggregation & Neurodegeneration (HPAN) has an active research program and/or collaboration to investigate the role of protein aggregation in neurodegenerative disease.  In addition, HPAN was chosen by the Dean to be a BioMed 21 Interdisciplinary Research Center, with an award of space in the new BJC Institute of Health and a financial commitment.

  • ances_beau (131x131)

    Beau Ances MD, PhD, MSc

    Associate Professor of Neurology

    Therapeutic Strategies for HIV Associated Neurocognitive Impairment Read More

  • ayala

    Yuna Ayala, PhD

    Assistant Professor of Biochemistry & Molecular Biology, St. Louis University

    Role of RNA processing and TDP-43 function in neurodegeneration Read More

  • Randall Bateman

    Randall Bateman, MD

    Charles F. and Joanne Knight Distinguished Professor of Neurology

    Alzheimer’s Disease: Pathophysiology, biomarkers, predictive diagnostics and treatments Read More

  • bieschke (150x150)

    Jan Bieschke, PhD

    Assistant Professor of Biomedical Engineering

    Mechanisms and therapeutic strategies in age-related protein misfolding Read More

  • blumer_kendall

    Kendall Blumer, PhD

    Professor of Cell Biology & Physiology

    Signal transduction in the cardiovascular, nervous and visual systems

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  • brody_david

    David Brody, MD, PhD

    Associate Professor of Neurology

    Translational research in traumatic brain injury Read More

  • cairns

    Nigel Cairns, PhD, FRCPath

    Professor of Neurology
    Professor of Pathology & Immunology

    Neuropathology of neurodegenerative diseases. Frontotemporal diseases. Protein misfolding. Models of neurodegeneration. Read More

  • Cashikar (150x150)

    Anil Cashikar, PhD

    Assistant Professor of Cell Biology & Physiology

    Multivesicular body and ESCRT functions in proteostasis Read More

  • chen_zhou-feng

    Zhou-Feng Chen, PhD

    Professor of Anesthesiology

    Molecular and cellular mechanisms of itch sensation

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  • cirrito_john

    John Cirrito, PhD

    Associate Professor of Neurology

    Relationship between synaptic activity and amyloid-beta metabolism in Alzheimer’s disease Read More

  • cruchaga (150x150)

    Carlos Cruchaga, PhD

    Associate Professor of Psychiatry

    Second-generation sequencing technology to identify rare variants implicated in neurodegenerative diseases Read More

  • dani_adish

    Adish Dani, PhD

    Assistant Professor of Pathology & Immunology

    High-resolution imaging of synaptic architecture and function Read More

  • diamond_marc

    Marc Diamond, MD

    Professor of Neurology & Neurotherapeutics, UT Southwestern Medical Center, Dallas, Texas

    Therapeutic Mechanisms in Human Disease: Polyglutamine Disease Pathogensis and Protein Misfolding in Tauopathy Read More

  • Diwan

    Abhinav Diwan, MD

    Assistant Professor of Medicine

    Regulation of Lysosome function in Cellular Physiology and Pathology Read More

  • Fagan

    Anne Fagan, PhD

    Professor of Neurology

    Cerebrospinal fluid and plasma biomarkers of early stage Alzheimer’s Disease Read More

  • frieden_carl

    Carl Frieden, PhD

    Professor of Biochemistry & Molecular Biophysics

    Protein folding, structure Read More

  • goate_alison

    Alison Goate, DPhil

    Icahn School of Medicine at Mount Sinai

    Genetic and genomic approaches to uncovering susceptibility to neurological and psychiatric diseases Read More

  • hallahan_dennis

    Dennis Hallahan, MD

    Elizabeth H and James S McDonnell III Distinguished Professor of Medicine

    The mechanisms of cell death in normal tissues during cancer therapy Read More

  • hanson_phyllis

    Phyllis Hanson, MD, PhD

    Professor of Cell Biology & Physiology

    Protein-protein and protein-membrane interactions in neuronal membrane trafficking Read More

  • Hershey

    Tamara Hershey, PhD

    Professor of Psychiatry

    Clinical and cognitive neuroscience Read More

  • Hodzic

    Didier Hodzic, PhD

    Assistant Professor of Ophthalmology & Visual Sciences

    Role of LINC complexes (Linkers of the Nucleoskeleton to the Cytoskeleton) in nucleokinesis and neuronal migration Read More

  • holtzman_david

    David Holtzman, MD

    Andrew B & Gretchen P Jones Professor of Neurology

    Cellular/Molecular/Biomarker studies of Alzheimer’s Disease and neonatal brain injury Read More

  • jain_sanjay

    Sanjay Jain, MD, PhD

    Associate Professor of Medicine

    GFL-Ret mediated mechanisms in the development, repair and regeneration of the nervous and urogenital systems Read More

  • Karch_small

    Celeste Karch, PhD

    Assistant Professor of Psychiatry

    Molecular mechanisms underlying tauopathies Read More

  • kotzbauer_paul

    Paul Kotzbauer, MD, PhD

    Associate Professor of Neurology

    Mechanisms of neurodegeneration in Parkinson’s disease and related disorders Read More

  • Lee

    Jin-Moo Lee, MD, PhD

    Professor of Neurology

    Understanding the molecular pathogenesis of spontaneous intracerebral hemorrhage Read More

  • li_mingjie

    Mingjie Li, MD, PhD

    Assistant Professor of Neurology

    Developing viral vectors for applications in neuroscience Read More

  • limbrick_david

    David Limbrick, MD, PhD

    Associate Professor of Neurosurgery

    Neuronal membrane physiology, patch-clamp electrophysiology, CSF proteomics, hydrocephalus, neuroprosthetics, brain tumor biology Read More

  • Lucey

    Brendan Lucey, MD

    Assistant Professor of Neurology

    Understanding the relationship between sleep, the amyloid beta diurnal pattern, and Alzheimer’s disease Read More

  • Moe-cropped-e1377703241760

    Moe Mahjoub, PhD

    Assistant Professor of Medicine

    Mechanisms of cell-cell signaling in normal development and neurodegenerative disease Read More

  • Soe Soe

    Soe Soe Mar, MD

    Associate Professor of Neurology

    Pediatric multiple sclerosis and other white matter diseases, and pediatric migraine Read More

  • mennerick_steven

    Steven Mennerick, PhD

    Professor of Psychiatry

    Physiology of glutamate and GABA neurotransmission in the CNS Read More

  • miller_tim

    Timothy Miller, MD, PhD

    David Clayson Professor of Neurology

    New, effective, and safe treatments for neurodegenerative diseases Read More

  • Mirica member page

    Liviu Mirica, PhD

    Associate Professor of Chemistry

    Development of therapeutic and imaging chemical agents for Alzheimer’s disease; Design of specific inhibitors of histone demethylases Read More

  • morris_john

    John Morris, MD

    Harvey A & Dorismae Hacker Friedman Distinguished Professor of Neurology

    Establishing phenotypes for inherited forms of Alzheimer’s disease and other dementias Read More

  • Musiek

    Erik Musiek, MD, PhD

    Assistant Professor of Neurology

    Aging, oxidative stress, and circadian clock genes in neurodegenerative diseases Read More

  • ornitz_david

    David Ornitz, MD, PhD

    Alumni Endowed Professor of Developmental Biology

    Neuronal development, regeneration, physiology Read More

  • ory_dan

    Daniel Ory, MD

    Alan A and Edith L Wolff Distinguished Professor of Medicine

    Molecular basis of Niemann-Pick C disease and the regulation of NPC1 and NPC2 genes in cholesterol homeostasis Read More

  • Pappu

    Rohit Pappu, PhD

    Edwin H. Murty Professor of Engineering

    Mechanisms of aggregation and neurodegeneration in polyglutamine expansion disorders, specifically Huntington’s disease Read More

  • Perlmutter

    David Perlmutter, MD

    Professor of Pediatrics, Executive Vice Chancellor for Medical Affairs and Dean

    Cellular mechanisms to clear misfolded proteins, and therapies to minimize toxicity by stimulating degradation of misfolded proteins Read More

  • perlmutter_joel

    Joel Perlmutter, MD

    Elliot Stein Professor of Neurology

    Pharmacology, physiology and pathophysiology of basal ganglia and movement disorders Read More

  • perrin

    Richard Perrin, MD, PhD

    Assistant Professor of Pathology & Immunology

    Novel cerebrospinal fluid biomarkers for early diagnosis, prognosis, and staging of neurodegenerative diseases
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  • pestronk_alan

    Alan Pestronk, MD

    Professor of Neurology

    Diagnosis, pathogenesis and treatment of immune, hereditary and degenerative neuromuscular disorders Read More

  • Petersen_S (126x126)

    Steve Petersen, PhD

    James S McDonnell Professor of Cognitive Neuroscience

    Behavioral and fMRI studies of attention and cognitive development Read More

  • raichle (150x149)

    Marcus Raichle, MD

    Alan A. and Edith L. Wolff Distinguished Professor of Medicine

    Functional brain imaging with positron emission tomography and magnetic resonance Read More

  • sands_mark

    Mark Sands, PhD

    Professor of Medicine

    Pathophysiology and novel therapies for lysosomal storage diseases Read More

  • schmidt_robert (150x150)

    Robert Schmidt, MD, PhD

    Professor of Pathology & Immunology

    Pathogenetic mechanisms of diabetic and age-related autonomic neuropathy Read More

  • Singh member page

    Itender Singh, PhD

    Assistant Professor of Neurosurgery

    Neurovascular dysfunction in Alzheimer’s disease (AD) and stroke Read More

  • snider_joy

    Joy Snider, MD, PhD

    Associate Professor of Neurology

    Mechanisms of protein degradation and intracellular calcium homeostasis in neurodegenerative disorders Read More

  • true_heather

    Heather True-Krob, PhD

    Associate Professor of Cell Biology & Physiology

    Protein misfolding and aggregation of prion proteins Read More

  • Urano Pic

    Fumihiko Urano, MD, PhD

    Samuel E Schechter Professor of Medicine

    Patient-based therapeutic development for Wolfram syndrome, the link between endoplasmic reticulum and neurodegeneration Read More

  • Vlassenko (150x150)

    Andrei Vlassenko, MD, PhD

    Assistant Professor of Radiology

    Advanced neuroimaging techniques in aging and neurodegenerative disorders Read More

  • yong pic

    Yong Wang, PhD

    Assistant Professor of Obstetrics & Gynecology

    Developing and applying MRI methods for quantification of pathological changes in neurodegeneration diseases Read More

  • weihl_chris

    Conrad (Chris) Weihl, MD, PhD

    Associate Professor of Neurology

    Protein degradation pathways and their relation to aging, muscle weakness and neurodegeneration Read More

  • wozniak_david

    David Wozniak, PhD

    Professor of Psychiatry

    Role of NMDA receptors in neuropathologic changes and cognitive decline Read More

  • admin-ajax (2)

    Qin Yang, MD, PhD

    Associate Professor of Radiation Oncology

    Understand neural cell reprogramming/regeneration and generate “safe” neural cells for neurological disorder treatment Read More

  • Yano (150x150)

    Hiroko Yano, PhD

    Assistant Professor of Neurosurgery

    Molecular pathogenesis of neurodegenerative diseases; Epigenetic regulation of gene expression in Huntington’s disease Read More

  • yoo

    Andrew Yoo, PhD

    Assistant Professor of Developmental Biology

    MicroRNA-mediated neuronal reprogramming and chromatin remodeling Read More

  • zipfel_greg

    Gregory Zipfel, MD

    Professor of Neurosurgery

    Role of cerebral amyloid angiopathy on cerebral blood flow, cerebral ischemia, cerebral hemorrhage, and dementia; Pathophysiology and novel therapeutic approaches for aneurysmal subarachnoid hemorrhage Read More