HPAN Faculty
Each faculty member of the Hope Center Program on Protein Aggregation & Neurodegeneration (HPAN) has an active research program and/or collaboration to investigate the role of protein aggregation in neurodegenerative disease. In addition, HPAN was chosen by the Dean to be a BioMed 21 Interdisciplinary Research Center, with an award of space in the new BJC Institute of Health and a financial commitment.
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Beau Ances MD, PhD, MSc
Associate Professor of Neurology
Therapeutic Strategies for HIV Associated Neurocognitive Impairment Read More
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Yuna Ayala, PhD
Assistant Professor of Biochemistry & Molecular Biology, St. Louis University
Role of RNA processing and TDP-43 function in neurodegeneration Read More
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Randall Bateman, MD
Charles F. and Joanne Knight Distinguished Professor of Neurology
Alzheimer’s Disease: Pathophysiology, biomarkers, predictive diagnostics and treatments Read More
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Jan Bieschke, PhD
Assistant Professor of Biomedical Engineering
Mechanisms and therapeutic strategies in age-related protein misfolding Read More
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Kendall Blumer, PhD
Professor of Cell Biology & Physiology
Signal transduction in the cardiovascular, nervous and visual systems
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David Brody, MD, PhD
Associate Professor of Neurology
Translational research in traumatic brain injury Read More
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Nigel Cairns, PhD, FRCPath
Research Professor of Neurology
Protein misfolding, inclusion formation and neurodegeneration in Frontotemperal Dementias Read More
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Anil Cashikar, PhD
Research Assistant Professor in Cell Biology & Physiology
Multivesicular body and ESCRT functions in proteostasis Read More
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Zhou-Feng Chen, PhD
Professor of Anesthesiology
Molecular and cellular mechanisms of itch sensation
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John Cirrito, PhD
Assistant Professor of Neurology
Relationship between synaptic activity and amyloid-beta metabolism in Alzheimer’s disease Read More
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Michael Crowder, MD, PhD
Dr. Seymour and Rose T Brown Professor of Anesthesiology
Fundamental mechanisms of neuronal cell death following hypoxic injury Read More
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Carlos Cruchaga, PhD
Assistant Professor of Psychiatry
Second-generation sequencing technology to identify rare variants implicated in neurodegenerative diseases Read More
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Adish Dani, PhD
Research Assistant Professor of Pathology & Immunology
High-resolution imaging of synaptic architecture and function Read More
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Marc Diamond, MD
David Clayson Professor of Neurology
Therapeutic Mechanisms in Human Disease: Polyglutamine Disease Pathogensis and Protein Misfolding in Tauopathy Read More
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Hans Dietrich, PhD
Assistant Professor of Neurological Surgery
Regulatory mechanisms of cerebrovascular microcirculation Read More
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Anne Fagan, PhD
Research Professor of Neurology
Cerebrospinal fluid and plasma biomarkers of early stage Alzheimer’s Disease Read More
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Simon Fisher, MD, PhD
Associate Professor of Medicine
Role of nutritional and hormonal brain signaling in pathogenesis of obesity, diabetes, and impaired hypoglycemic counterregulation
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Carl Frieden, PhD
Professor of Biochemistry & Molecular Biophysics
Protein folding, structure Read More
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Jeff Gidday, PhD
Associate Professor of Neurological Surgery
Identifying endogenous epigenetic mechanisms of neurovascular protection in acute and chronic disease Read More
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Alison Goate, DPhil
Samuel & Mae S Ludwig Professor of Genetics in Psychiatry
Genetic and genomic approaches to uncovering susceptibility to neurological and psychiatric diseases Read More
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Dennis Hallahan, MD
Elizabeth H and James S McDonnell III Distinguished Professor
The mechanisms of cell death in normal tissues during cancer therapy Read More
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Byung-Hee (Henry) Han, PhD
Assistant Professor of Neurological Surgery
Mechanisms of CAA-induced cerebrovascular impairment Read More
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Phyllis Hanson, MD, PhD
Professor of Cell Biology & Physiology
Protein-protein and protein-membrane interactions in neuronal membrane trafficking Read More
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Matthew Harms, MD
Assistant Professor of Neurology
Genetic causes of hereditary neuromuscular diseases Read More
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Tamara Hershey, PhD
Professor of Psychiatry
Clinical and cognitive neuroscience Read More
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Robert Heuckeroth, MD, PhD
Alumni Endowed Professor of Pediatrics
Molecular mechanisms of neuronal development Read More
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Didier Hodzic, PhD
Assistant Professor of Ophthalmology & Visual Sciences
Role of LINC complexes (Linkers of the Nucleoskeleton to the Cytoskeleton) in nucleokinesis and neuronal migration Read More
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David Holtzman, MD
Andrew B & Gretchen P Jones Professor of Neurology
Cellular/Molecular/Biomarker studies of Alzheimer’s Disease and neonatal brain injury Read More
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Sanjay Jain, MD, PhD
Associate Professor of Medicine
GFL-Ret mediated mechanisms in the development, repair and regeneration of the nervous and urogenital systems Read More
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Celeste Karch, PhD
Research Instructor in Psychiatry
Molecular mechanisms underlying tauopathies Read More
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Paul Kotzbauer, MD, PhD
Assistant Professor of Neurology
Mechanisms of neurodegeneration in Parkinson’s disease and related disorders Read More
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Jin-Moo Lee, MD, PhD
Professor of Neurology
Understanding the molecular pathogenesis of spontaneous intracerebral hemorrhage Read More
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Mingjie Li, MD, PhD
Research Assistant Professor of Neurology
Developing viral vectors for applications in neuroscience Read More
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David Limbrick, MD, PhD
Associate Professor of Neurological Surgery
Neuronal membrane physiology, patch-clamp electrophysiology, CSF proteomics, hydrocephalus, neuroprosthetics, brain tumor biology Read More
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Moe Mahjoub, PhD
Assistant Professor of Medicine
Mechanisms of cell-cell signaling in normal development and neurodegenerative disease Read More
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Steven Mennerick, PhD
Professor of Psychiatry
Physiology of glutamate and GABA neurotransmission in the CNS Read More
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Timothy Miller, MD, PhD
Associate Professor of Neurology
Mechanisms of neurodegeneration and gene targeted therapies in motor neuron diseases Read More
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John Morris, MD
Harvey A & Dorismae Hacker Friedman Distinguished Professor of Neurology
Establishing phenotypes for inherited forms of Alzheimer’s disease and other dementias Read More
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Erik Musiek, MD, PhD
Assistant Professor of Neurology
Aging, oxidative stress, and circadian clock genes in neurodegenerative diseases. Read More
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David Ornitz, MD, PhD
Alumni Endowed Professor of Developmental Biology
Neuronal development, regeneration, physiology Read More
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Daniel Ory, MD
Alan A and Edith L Wolff Distinguished Professor of Medicine
Molecular basis of Niemann-Pick C disease and the regulation of NPC1 and NPC2 genes in cholesterol homeostasis Read More
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Rohit Pappu, PhD
Professor of Biomedical Engineering
Mechanisms of aggregation and neurodegeneration in polyglutamine expansion disorders, specifically Huntington’s disease Read More
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Joel Perlmutter, MD
Elliot Stein Professor of Neurology
Pharmacology, physiology and pathophysiology of basal ganglia and movement disorders Read More
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Richard Perrin, MD, PhD
Assistant Professor of Pathology & Immunology
Novel cerebrospinal fluid biomarkers for early diagnosis, prognosis, and staging of neurodegenerative diseases
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Alan Pestronk, MD
Professor of Neurology
Diagnosis, pathogenesis and treatment of immune, hereditary and degenerative neuromuscular disorders Read More
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Steve Petersen, PhD
James S McDonnell Professor of Cognitive Neuroscience
Behavioral and fMRI studies of attention and cognitive development Read More
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Marcus Raichle, MD
Professor of Radiology
Functional brain imaging with positron emission tomography and magnetic resonance Read More
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Mark Sands, PhD
Professor of Medicine
Pathophysiology and novel therapies for lysosomal storage diseases Read More
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Robert Schmidt, MD, PhD
Professor of Pathology & Immunology
Pathogenetic mechanisms of diabetic and age-related autonomic neuropathy Read More
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Joy Snider, MD, PhD
Associate Professor of Neurology
Mechanisms of protein degradation and intracellular calcium homeostasis in neurodegenerative disorders Read More
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Heather True-Krob, PhD
Associate Professor of Cell Biology & Physiology
Protein misfolding and aggregation of prion proteins Read More
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Fumihiko Urano, MD, PhD
Samuel E Schechter Professor of Medicine
Patient-based therapeutic development for Wolfram syndrome, the link between endoplasmic reticulum and neurodegeneration Read More
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Andrei Vlassenko, MD, PhD
Research Assistant Professor of Radiology
Advanced neuroimaging techniques in aging and neurodegenerative disorders Read More
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Yong Wang, PhD
Research Instructor of Radiology
Developing and applying MRI methods for quantification of pathological changes in neurodegeneration diseases Read More
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Conrad (Chris) Weihl, MD, PhD
Associate Professor of Neurology
Protein degradation pathways and their relation to aging, muscle weakness and neurodegeneration Read More
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David Wozniak, PhD
Research Professor of Psychiatry
Role of NMDA receptors in neuropathologic changes and cognitive decline Read More
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Qin Yang, MD, PhD
Associate Professor of Radiation Oncology
Understand neural cell reprogramming/regeneration and generate “safe” neural cells for neurological disorder treatment Read More
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Hiroko Yano, PhD
Assistant Professor of Neurological Surgery
Molecular pathogenesis of neurodegenerative diseases; Epigenetic regulation of gene expression in Huntington’s disease Read More
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Andrew Yoo, PhD
Assistant Professor of Developmental Biology
MicroRNA-mediated neuronal reprogramming and chromatin remodeling Read More
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Gregory Zipfel, MD
Associate Professor of Neurological Surgery
Role of cerebral amyloid angiopathy on cerebral blood flow, cerebral ischemia, cerebral hemorrhage, and dementia; Pathophysiology and novel therapeutic approaches for aneurysmal subarachnoid hemorrhage Read More
