Representing fourteen academic departments and both campuses of Washington University Read More

HPAN Faculty

Each faculty member of the Hope Center Program on Protein Aggregation & Neurodegeneration (HPAN) has an active research program and/or collaboration to investigate the role of protein aggregation in neurodegenerative disease.  In addition, HPAN was chosen by the Dean to be a BioMed 21 Interdisciplinary Research Center, with an award of space in the new BJC Institute of Health and a financial commitment.

  • ances_beau (131x131)

    Beau Ances MD, PhD, MSc

    Associate Professor of Neurology

    Therapeutic Strategies for HIV Associated Neurocognitive Impairment Read More

  • ayala

    Yuna Ayala, PhD

    Assistant Professor of Biochemistry & Molecular Biology, St. Louis University

    Role of RNA processing and TDP-43 function in neurodegeneration Read More

  • Randall Bateman

    Randall Bateman, MD

    Charles F. and Joanne Knight Distinguished Professor of Neurology

    Alzheimer’s Disease: Pathophysiology, biomarkers, predictive diagnostics and treatments Read More

  • bieschke (150x150)

    Jan Bieschke, PhD

    Assistant Professor of Biomedical Engineering

    Mechanisms and therapeutic strategies in age-related protein misfolding Read More

  • blumer_kendall

    Kendall Blumer, PhD

    Professor of Cell Biology & Physiology

    Signal transduction in the cardiovascular, nervous and visual systems

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  • brody_david

    David Brody, MD, PhD

    Associate Professor of Neurology

    Translational research in traumatic brain injury Read More

  • cairns_nigel

    Nigel Cairns, PhD, FRCPath

    Professor of Neurology

    Protein misfolding, inclusion formation and neurodegeneration in Frontotemperal Dementias Read More

  • Cashikar (150x150)

    Anil Cashikar, PhD

    Assistant Professor in Cell Biology & Physiology

    Multivesicular body and ESCRT functions in proteostasis Read More

  • chen_zhou-feng

    Zhou-Feng Chen, PhD

    Professor of Anesthesiology

    Molecular and cellular mechanisms of itch sensation

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  • cirrito_john

    John Cirrito, PhD

    Associate Professor of Neurology

    Relationship between synaptic activity and amyloid-beta metabolism in Alzheimer’s disease Read More

  • cruchaga (150x150)

    Carlos Cruchaga, PhD

    Associate Professor of Psychiatry

    Second-generation sequencing technology to identify rare variants implicated in neurodegenerative diseases Read More

  • dani_adish

    Adish Dani, PhD

    Assistant Professor of Pathology & Immunology

    High-resolution imaging of synaptic architecture and function Read More

  • diamond_marc

    Marc Diamond, MD

    Adjunct Professor at Washington University, Professor of Neurology & Neurotherapeutics, UT Southwestern Medical Center

    Therapeutic Mechanisms in Human Disease: Polyglutamine Disease Pathogensis and Protein Misfolding in Tauopathy Read More

  • Diwan

    Abhinav Diwan, MD

    Assistant Professor of Medicine

    Regulation of Lysosome function in Cellular Physiology and Pathology Read More

  • Fagan

    Anne Fagan, PhD

    Professor of Neurology

    Cerebrospinal fluid and plasma biomarkers of early stage Alzheimer’s Disease Read More

  • frieden_carl

    Carl Frieden, PhD

    Professor of Biochemistry & Molecular Biophysics

    Protein folding, structure Read More

  • gidday_jeff

    Jeff Gidday, PhD

    Associate Professor of Neurological Surgery

    Identifying endogenous epigenetic mechanisms of neurovascular protection in acute and chronic disease Read More

  • goate_alison

    Alison Goate, DPhil

    Director, Center on Alzheimer’s Disease
    Icahn School of Medicine at Mount Sinai

    Genetic and genomic approaches to uncovering susceptibility to neurological and psychiatric diseases Read More

  • hallahan_dennis

    Dennis Hallahan, MD

    Elizabeth H and James S McDonnell III Distinguished Professor of Medicine

    The mechanisms of cell death in normal tissues during cancer therapy Read More

  • hanson_phyllis

    Phyllis Hanson, MD, PhD

    Professor of Cell Biology & Physiology

    Protein-protein and protein-membrane interactions in neuronal membrane trafficking Read More

  • Hershey

    Tamara Hershey, PhD

    Professor of Psychiatry

    Clinical and cognitive neuroscience Read More

  • Hodzic

    Didier Hodzic, PhD

    Assistant Professor of Ophthalmology & Visual Sciences

    Role of LINC complexes (Linkers of the Nucleoskeleton to the Cytoskeleton) in nucleokinesis and neuronal migration Read More

  • holtzman_david

    David Holtzman, MD

    Andrew B & Gretchen P Jones Professor of Neurology

    Cellular/Molecular/Biomarker studies of Alzheimer’s Disease and neonatal brain injury Read More

  • jain_sanjay

    Sanjay Jain, MD, PhD

    Associate Professor of Medicine

    GFL-Ret mediated mechanisms in the development, repair and regeneration of the nervous and urogenital systems Read More

  • Karch_small

    Celeste Karch, PhD

    Assistant Professor of Psychiatry

    Molecular mechanisms underlying tauopathies Read More

  • kotzbauer_paul

    Paul Kotzbauer, MD, PhD

    Associate Professor of Neurology

    Mechanisms of neurodegeneration in Parkinson’s disease and related disorders Read More

  • Lee

    Jin-Moo Lee, MD, PhD

    Professor of Neurology

    Understanding the molecular pathogenesis of spontaneous intracerebral hemorrhage Read More

  • li_mingjie

    Mingjie Li, MD, PhD

    Assistant Professor of Neurology

    Developing viral vectors for applications in neuroscience Read More

  • limbrick_david

    David Limbrick, MD, PhD

    Associate Professor of Neurological Surgery

    Neuronal membrane physiology, patch-clamp electrophysiology, CSF proteomics, hydrocephalus, neuroprosthetics, brain tumor biology Read More

  • Lucey

    Brendan Lucey, MD

    Assistant Professor of Neurology

    Understanding the relationship between sleep, the amyloid beta diurnal pattern, and Alzheimer’s disease Read More

  • Moe-cropped-e1377703241760

    Moe Mahjoub, PhD

    Assistant Professor of Medicine

    Mechanisms of cell-cell signaling in normal development and neurodegenerative disease Read More

  • Soe Soe

    Soe Soe Mar, MD

    Associate Professor of Neurology

    Pediatric multiple sclerosis and other white matter diseases, and pediatric migraine Read More

  • mennerick_steven

    Steven Mennerick, PhD

    Professor of Psychiatry

    Physiology of glutamate and GABA neurotransmission in the CNS Read More

  • miller_tim

    Timothy Miller, MD, PhD

    David Clayson Professor of Neurology

    Mechanisms of neurodegeneration and gene targeted therapies in motor neuron diseases Read More

  • Mirica member page

    Liviu Mirica, PhD

    Associate Professor of Chemistry

    Development of therapeutic and imaging chemical agents for Alzheimer’s disease; Design of specific inhibitors of histone demethylases Read More

  • morris_john

    John Morris, MD

    Harvey A & Dorismae Hacker Friedman Distinguished Professor of Neurology

    Establishing phenotypes for inherited forms of Alzheimer’s disease and other dementias Read More

  • Musiek

    Erik Musiek, MD, PhD

    Assistant Professor of Neurology

    Aging, oxidative stress, and circadian clock genes in neurodegenerative diseases Read More

  • ornitz_david

    David Ornitz, MD, PhD

    Alumni Endowed Professor of Developmental Biology

    Neuronal development, regeneration, physiology Read More

  • ory_dan

    Daniel Ory, MD

    Alan A and Edith L Wolff Distinguished Professor of Medicine

    Molecular basis of Niemann-Pick C disease and the regulation of NPC1 and NPC2 genes in cholesterol homeostasis Read More

  • Pappu

    Rohit Pappu, PhD

    Edwin H. Murty Professor of Engineering

    Mechanisms of aggregation and neurodegeneration in polyglutamine expansion disorders, specifically Huntington’s disease Read More

  • perlmutter_joel

    Joel Perlmutter, MD

    Elliot Stein Professor of Neurology

    Pharmacology, physiology and pathophysiology of basal ganglia and movement disorders Read More

  • perrin

    Richard Perrin, MD, PhD

    Assistant Professor of Pathology & Immunology

    Novel cerebrospinal fluid biomarkers for early diagnosis, prognosis, and staging of neurodegenerative diseases
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  • pestronk_alan

    Alan Pestronk, MD

    Professor of Neurology

    Diagnosis, pathogenesis and treatment of immune, hereditary and degenerative neuromuscular disorders Read More

  • Petersen_S (126x126)

    Steve Petersen, PhD

    James S McDonnell Professor of Cognitive Neuroscience

    Behavioral and fMRI studies of attention and cognitive development Read More

  • raichle (150x149)

    Marcus Raichle, MD

    Alan A. and Edith L. Wolff Distinguished Professor of Medicine

    Functional brain imaging with positron emission tomography and magnetic resonance Read More

  • sands_mark

    Mark Sands, PhD

    Professor of Medicine

    Pathophysiology and novel therapies for lysosomal storage diseases Read More

  • schmidt_robert (150x150)

    Robert Schmidt, MD, PhD

    Professor of Pathology & Immunology

    Pathogenetic mechanisms of diabetic and age-related autonomic neuropathy Read More

  • Singh member page

    Itender Singh, PhD

    Assistant Professor of Neurosurgery

    Neurovascular dysfunction in Alzheimer’s disease (AD) and stroke Read More

  • snider_joy

    Joy Snider, MD, PhD

    Associate Professor of Neurology

    Mechanisms of protein degradation and intracellular calcium homeostasis in neurodegenerative disorders Read More

  • true_heather

    Heather True-Krob, PhD

    Associate Professor of Cell Biology & Physiology

    Protein misfolding and aggregation of prion proteins Read More

  • Urano Pic

    Fumihiko Urano, MD, PhD

    Samuel E Schechter Professor of Medicine

    Patient-based therapeutic development for Wolfram syndrome, the link between endoplasmic reticulum and neurodegeneration Read More

  • Vlassenko (150x150)

    Andrei Vlassenko, MD, PhD

    Assistant Professor of Radiology

    Advanced neuroimaging techniques in aging and neurodegenerative disorders Read More

  • yong pic

    Yong Wang, PhD

    Assistant Professor of Obstetrics & Gynecology

    Developing and applying MRI methods for quantification of pathological changes in neurodegeneration diseases Read More

  • weihl_chris

    Conrad (Chris) Weihl, MD, PhD

    Associate Professor of Neurology

    Protein degradation pathways and their relation to aging, muscle weakness and neurodegeneration Read More

  • wozniak_david

    David Wozniak, PhD

    Professor of Psychiatry

    Role of NMDA receptors in neuropathologic changes and cognitive decline Read More

  • admin-ajax (2)

    Qin Yang, MD, PhD

    Associate Professor of Radiation Oncology

    Understand neural cell reprogramming/regeneration and generate “safe” neural cells for neurological disorder treatment Read More

  • Yano (150x150)

    Hiroko Yano, PhD

    Assistant Professor of Neurological Surgery

    Molecular pathogenesis of neurodegenerative diseases; Epigenetic regulation of gene expression in Huntington’s disease Read More

  • yoo

    Andrew Yoo, PhD

    Assistant Professor of Developmental Biology

    MicroRNA-mediated neuronal reprogramming and chromatin remodeling Read More

  • zipfel_greg

    Gregory Zipfel, MD

    Associate Professor of Neurological Surgery

    Role of cerebral amyloid angiopathy on cerebral blood flow, cerebral ischemia, cerebral hemorrhage, and dementia; Pathophysiology and novel therapeutic approaches for aneurysmal subarachnoid hemorrhage Read More