November 21: Season kick-off
- Alison Goate, “State of the Hope Center”
- Renate Lewis, “Zinc Finger Nucleases and TAL Effector Nucleases: Powerful New Tools for Genome Modification”
- Michael Bruchas, “In vivo Optogenetics for Mapping Neural Circuits”
Neurovirology mini-series
Organizer, Beau Ances
- November 28: Beau Ances (WUSTL Neurology), “Magic Moments: Lessons Learned from NeuroAIDS”
- December 5: Robyn Klein (WUSTL Internal Medicine),”Who let the dogs out? Protective versus pathologic immunity in viral encephalitis”
- December 12: David Clifford (WUSTL Neurology), “Progressive multifocal leuko encephalopathy”
- December 19: Ken Tyler (University of Colorado, Denver), “Veni, Vidi, Vici (I came, I saw, I conquered): Reovirus-induced cell death in the CNS”
Epigenetics and Epigenomics mini-series
Organizer, Joe Dougherty
- January 9: Skirmantas Kriaucionis (University of Oxford), “DNA modifications in brain cells – identity and functional implications”
- January 23: Sarah Elgin (WUSTL Biology), “Targeting Heterochromatin Formation in Drosophila”
- January 30: Ting Wang (WUSTL Genetics), “Transposable elements, landscapers for shaping genetic and epigenetic regulatory network”
- February 6: Kristen Kroll (WUSTL Developmental Biology), “Epigenetic regulation of neural development: making stem cells into neurons”
CNS Endothelium in Health and Disease mini-series
Organizers, Robyn Klein and Josh Rubin
- February 13: Dennis Hallahan (WUSTL Radiation Oncology),“Exploiting the Physiologic Response of Ionizing Radiation in Microvasculature of Brain Tumors”
- February 20: Josh Rubin (WUSTL Pediatrics), “Eavesdropping on a brain tumor-vascular endothelial cell tete a tete”
- February 27: Greg Zipfel (WUSTL Neurosurgery), “The role of endothelial cell and smooth muscle cell dysfunction in subarachnoid hemorrhage-induced cerebral vasospasm”
- March 5: Kelly Doran (University of California, San Diego), “Blood-Brain Barrier Failure during Bacterial Meningitis”
Prion-like mechanisms mini-series
Organizer, Marc Diamond
- March 19: Jan Bieschke (WUSTL Biomedical Engineering), “Therapeutic strategies for interfering with amyloid formation and propagation”
- March 26: Marc Diamond (WUSTL Neurology), “Transcellular propagation of misfolding: A framework for new therapeutic and diagnostic opportunities in neurodegenerative disease”
- April 2: William Seeley** (University of California, San Francisco),“Selective vulnerability in neurodegenerative disease: insights from frontotemporal dementia”
- April 9: Special seminar (see below)
- April 16: Heather True (WUSTL Cell Biology & Physiology), “Prions: 31 Flavors of Infectious Particles”
**William Seeley’s talk on April 2 is co-hosted by the Neuroimaging Informatics and Analysis Center (NIAC).
Protein Homeostasis mini-series
Organizer, Chris Weihl
- April 30: Chris Weihl (WUSTL Neurology),“Promiscuous Proteinopathies: chaperone function and degenerative disease”
- May 2: Special Seminar (see below)
- May 7: Paul Taylor (St. Jude Children’s Research Hospital), “Mutations in prion-like domains found in two RNA-binding proteins cause multisystem proteinopathy”
- May 21: Rohit Pappu (WUSTL Biomedical Engineering), “Sequence context as functional modules, gatekeepers and regulators of homeostasis”
Special seminars
- April 9: Ron DeMattos (Eli Lilly and Company), “Engaging the Enemy: Novel Insights for Alzheimer’s Immunotherapy”
- May 2: Takaomi Saido (Riken Brain Science Institute), “A new mouse model of Alzheimer’s disease: Distinguishing facts from artifacts”
