The overall objective of the Animal Surgery Core (ASC) is to assist translation of scientific discoveries to rodent models and to facilitate development of new therapeutic strategies for nervous system disorders. The ASC provides access to core equipment and facilities, and expertise for surgery or protocol development. In addition, specific surgical and genetic models of disease will be made available to the Washington University community to accelerate investigation in disorder-related neuroscience.
Additionally, equipment in the facility is open to Hope Center investigators who complete appropriate training. Animal Studies Committee approval is required.
Scroll down to learn about services and equipment in the core, as well as suggested language for acknowledging core use.
Rodent surgical and pharmacological models
- Stroke (focal and global ischemia) models
- Stereotaxic brain injections (for virus, tracers)
- Brain and spinal cord traumatic injury
- Epilepsy models and monitoring
- Perinatal hypoxia/ischemia
- Interface with microscopy core for in vivo imaging
Veterinary care resources
- Animal survival care and facilities
- Animal safety, protocols, ASC approvals
- Surgical stereo dissecting microscopes
- Autoregulated thermocontrollers
- Surgical drills
- Laser doppler Transonic system and Perimed Periflux system 5000
- Inhalant anesthesia delivery system (Isotec)
- Drug infusion pumps
- Stoelting Nano injector
- Drummond nano injector
- Spinal cord injury impactor (NYU model)
- Biosafety hood for viral delivery
- Surgical Instruments Sterilizer (Tuttnauer)
- Light source Schott KL 2500 LCD for Photothrombosis
- Digital Blood Pressure Monitor (Digimed BPA)
- Gas Mixing Device (VTI O2 analyzer-Aalborg)
- ThermoCare Incubator
- Short-term rodent housing
Tissue preparation and histology:
- Animal perfusion set up
- Paraffin embedding unit
- Fluorescent microscope
Acknowledging the Core
The Animal Surgery Core has received additional support via the grants below. Publications that include data from core use should acknowledge grants as appropriate (suggested language below). Please note that end-dates for grants are included to help determine relevant support. Acknowledgements are crucial in tracking success of the core and obtaining future funding, and are required by the NIH Public Access Policy.
- NIH Neuroscience Blueprint Interdisciplinary Center Core Grant (P30 NS057105)
- End date: August 31, 2013
Suggested language to include in acknowledgements: “This work was supported by the Hope Center Animal Surgery Core and a P30 Neuroscience Blueprint Interdisciplinary Center Core award to Washington University (P30 NS057105).”
We always strive to improve services and resources offered by the Hope Center Cores. To provide feedback, see contact information below.
To initiate a new project, contact Karen Smith.