Active Pilot Projects

Pilot Project awards in 2019 and 2020 Read More

Role of satellite glia cells in chemotherapy-induced neuropathy

2020 Award

Principal Investigator: Stefanie Geisler (WashU Neurology)
Collaborator: Valeria Cavalli (WashU Dept. of Neuroscience)

Pilot Project Details

Microglial Phagocytosis as a Determinant of Neuro-inflammation in AD pathogenesis

2020 Award

Principal investigator: Abhinav Diwan (WashU Medicine)
Collaborators: Carolina Soriano Tarraga (WashU Psychiatry), Oscar Harari (WashU Psychiatry)

Pilot Project Details

Defining the molecular basis for inhibiting LRP1-mediated cellular propagation of pathogenic tau

2020 Award

Principal Investigator: Thomas Brett (WashU Medicine)
Collaborator: Gaya Amarasinghe (WashU Pathology & Immunology)

Pilot Project Details

A synthetic gene therapy approach for Angelman syndrome

2020 Award

Principal Investigator: Jason Yi (WashU Dept of Neuroscience)
Collaborator: Susan Maloney (WashU Psychiatry)

Pilot Project Details

Targeting DNMT3A as a therapeutic strategy for Huntington’s disease

2020 Award

Principal Investigator: Hiroko Yano (WashU Neurosurgery)
Collaborator: Andrew Yoo (WashU Developmental Biology), Allegra Petti (WashU Neurosurgery)

Pilot Project Details

Determining the pathogenic role of FGFR3 autoantibodies in idiopathic small fiber neuropathy

2019 Award

Principal Investigator: Robert Gereau (WashU Anesthesiology)
Collaborator: David Ornitz (WashU Developmental Biology)

Pilot Project Details

Reversibility of amyloid-induced mitochondrial dysfunction in Alzheimer’s disease

2019 Award

Principal Investigator: Jin-Moo Lee (WashU Neurology)
Collaborator: Song Hu (WashU Biomedical Engineering)

Pilot Project Details

SARM1 inhibition as a novel therapeutic strategy for Cln1 disease

2019 Award

Principal Investigator: Aaron DiAntonio (WashU Developmental Biology)
Collaborator: Jonathan Cooper (WashU Pediatrics), Mark Sands (WashU Medicine)

Pilot Project Details

Internet of things (IoT) monitoring of rodent home-cages to understand circadian plasticity

2019 Award

Principal Investigator: Alexxai Kravitz (WashU Psychiatry)
Collaborator: Erik Herzog (WashU Biology)

Pilot Project Details

DNA methylation in Alzheimer’s disease

2019 Award

Principal Investigator: Oscar Harari (WashU Psychiatry)
Collaborator: Ting Wang (WashU Genetics)

Pilot Project Details

Previous Pilot Awards

Hope Center Pilot awards are two-year projects.  Click below to learn details about past pilot projects.

Previous pilot awards