Active Pilot Projects

Pilot Projects awarded in 2014 and 2015. Read More

Fixing the Broken Clock: Optogenetic methods to restore circadian rhythms in a mouse model of Alzheimer’s Disease

2015 Award
Principal Investigator: Erik Musiek (WUSTL Neurology)
Collaborators: Erik Herzog (WUSTL Biology) and Geraldine Kress (WUSTL Neurology)

Pilot Project Details

Mechanisms of neonatal seizures in a mouse model of term-equivalent cerebral hypoxia-ischemia

2015 Award
Principal Investigator: Michael Wong (WUSTL Neurology)
Collaborator: Rafael Galindo (WUSTL Neurology)

Pilot Project Details

MicroRNA regulation of dendritic cell function in an animal model of multiple sclerosis

2015 Award
Principal Investigator: Gregory Wu (WUSTL Neurology)
Collaborator: Timothy Miller (WUSTL Neurology)

Pilot Project Details

The role of DNA methylation in Huntington’s disease

2015 Award
Principal Investigator:  Hiroko Yano (WUSTL Neurosurgery)
Collaborator: Ting Wang (WUSTL Genetics)

Pilot Project Details

Neuronal subtype-specific vulnerability in tauopathies using reprogramming methods in human somatic and stem cells

2014 Award
Principal Investigator: Celeste Karch (WUSTL Psychiatry)
Collaborator: Andrew Yoo (WUSTL Developmental Biology)

Pilot Project Details

Identification and functional characterization of rare variants in DNAJC5/CSP gene associated with Alzheimer Disease

2014 Award
Principal Investigators: Carlos Cruchaga (WUSTL Psychiatry) and Bruno Benitez (WUSTL Internal Medicine)

Pilot Project Details

Characterization of neural bridge circuits for spinal cord repair

2014 Award
Principal Investigator: Shelly Sakiyama-Elbert (WUSTL Biomedical Engineering)
Collaborator: Dennis Barbour (WUSTL Biomedical Engineering)

Pilot Project Details

MR Elastography and CSF Biomarkers in Post-Hemorrhagic Hydrocephalus

2014 Award
Principal Investigator: David Limbrick (WUSTL Neurosurgery)
Collaborators: Pat McAllister (WUSTL Neurosurgery), Philip Bayly (WUSTL Mechanical Engineering), Robyn Klein (WUSTL Internal Medicine)

Pilot Project Details

Role of nicotinamide adenine dinucleotide (NAD+) metabolism in the pathogenesis of retinal neurodegeneration

2014 Award
Principal Investigator: Shin-Ichiro Imai (WUSTL Developmental Biology)
Collaborator: Rajendra Apte (WUSTL Ophthalmology & Visual Sciences)

Pilot Project Details

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Previous Pilot Awards

Hope Center Pilot awards are two-year projects.  Click below to learn details about past pilot projects.

Previous pilot awards