News & Publications for:

Carlos Cruchaga

Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease

Posted on January 31, 2019

Oliver Preische, Stephanie A. Schultz, Anja Apel, Jens Kuhle, Stephan A. Kaeser, Christian Barro, Susanne Gräber, Elke Kuder-Buletta, Christian LaFougere, Christoph Laske, Jonathan Vöglein, Johannes Levin, Colin L. Masters, Ralph Martins, Peter R. Schofield, Martin N. Rossor, Neill R. Graff-Radford, Stephen Salloway, Bernardino Ghetti, John M. Ringman, James M. Noble, Jasmeer Chhatwal, Alison M. Goate, Tammie L. S. Benzinger, John C. Morris, Randall J. Bateman, Guoqiao Wang, Anne M. Fagan, Eric M. McDade, Brian A. Gordon, Mathias Jucker & Dominantly Inherited Alzheimer Network. Nature Medicine 2019 Read More

Posted in: HPAN, Neurodegeneration, Publications Faculty: , , , , , , , ,

Early increase of CSF sTREM2 in Alzheimer’s disease is associated with tau related-neurodegeneration but not with amyloid-β pathology

Posted on January 23, 2019

Marc Suárez-Calvet, Estrella Morenas-Rodríguez, Gernot Kleinberger, Kai Schlepckow, Miguel Ángel Araque Caballero, Nicolai Franzmeier, Anja Capell, Katrin Fellerer, Brigitte Nuscher, Erden Eren, Johannes Levin, Yuetiva Deming, Laura Piccio, Celeste M. Karch, Carlos Cruchaga, Leslie M. Shaw, John Q. Trojanowski, Michael Weiner, Michael Ewers, Christian Haass and for the Alzheimer’s Disease Neuroimaging Initiative. Molecular Neurodegeneration, Volume 14, Issue 1, 10 January 2019, Article number 1 Read More

Posted in: Axon Injury & Repair, HPAN, Lysosome, Neurodegeneration, Neurogenetics & Transcriptomics, Publications Faculty: , ,

Assessment of Racial Disparities in Biomarkers for Alzheimer Disease

Posted on January 16, 2019

John C. Morris, Suzanne E. Schindler, Lena M. McCue, Krista L. Moulder, Tammie L. S. Benzinger, Carlos Cruchaga, Anne M. Fagan, Elizabeth Grant, Brian A. Gordon, David M. Holtzman, Chengjie Xiong. JAMA Neurology 2018 Read More

Posted in: Axon Injury & Repair, Clocks & Sleep, HPAN, Lysosome, Neurodegeneration, Neurogenetics & Transcriptomics, Publications Faculty: , , , ,

Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP

Posted on December 27, 2018

Shan Jiang, Natalie Wen, Zeran Li, Umber Dube, Jorge Del Aguila, John Budde, Rita Martinez, Simon Hsu, Maria V. Fernandez, Nigel J. Cairns, Dominantly Inherited Alzheimer Network (DIAN), International FTD-Genomics Consortium (IFGC), Oscar Harari, Carlos Cruchaga & Celeste M. Karch . Translational Psychiatry, Volume 8, Issue 1, 1 December 2018, Article number 265 Read More

Posted in: Axon Injury & Repair, HPAN, Neurodegeneration, Neurogenetics & Transcriptomics, Pilot Projects, Publications Faculty: , ,

Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia

Posted on December 17, 2018

Vivek Swarup, Flora I. Hinz, Jessica E. Rexach, Ken-ichi Noguchi, Hiroyoshi Toyoshiba, Akira Oda, Keisuke Hirai, Arjun Sarkar, Nicholas T. Seyfried, Chialin Cheng, Stephen J. Haggarty, International Frontotemporal Dementia Genomics Consortium, Murray Grossman, Vivianna M. Van Deerlin, John Q. Trojanowski, James J. Lah, Allan I. Levey, Shinichi Kondou & Daniel H. Geschwind. Nature Medicine 2018 Read More

Posted in: HPAN, Lysosome, Neurodegeneration, Neurogenetics & Transcriptomics Faculty: