News & Publications for:

Carlos Cruchaga

APOE genotype regulates pathology and disease progression in synucleinopathy

Posted on February 20, 2020

Albert A. Davis, Casey E. Inman, Zachary M. Wargel, Umber Dube, Brittany M. Freeberg, Alexander Galluppi, Jessica N. Haines, Dhruva D. Dhavale, Rebecca Miller, Fahim A. Choudhury, Patrick M. Sullivan, Carlos Cruchaga, Joel S. Perlmutter, Jason D. Ulrich, Bruno A. Benitez, Paul T. Kotzbauer and David M. Holtzman. Science Translational Medicine, Volume 12, Issue 529, 5 February 2020 Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, Neurogenetics & Transcriptomics, Publications Faculty: , , , ,

Overlapping genetic architecture between Parkinson disease and melanoma

Posted on January 4, 2020

Umber Dube, Laura Ibanez, John P. Budde, Bruno A. Benitez, Albert A. Davis, Oscar Harari, Mark M. Iles, Matthew H. Law, Kevin M. Brown, 23andMe Research Team, Melanoma-Meta-analysis Consortium, Carlos Cruchaga. Acta Neuropathologica 2019 Read More

Posted in: HPAN, Lysosome, Neurodegeneration, Neurogenetics & Transcriptomics, Publications Faculty: , ,

An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations

Posted on November 6, 2019

Umber Dube, Jorge L Del-Aguila, Zeran Li, John P Budde, Shan Jiang, Simon Hsu, Laura Ibanez, Maria Victoria Fernandez, Fabiana Farias, Joanne Norton, Jen Gentsch, Fengxian Wang, the Dominantly Inherited Alzheimer Network (DIAN), Stephen Salloway, Colin L Masters, Jae-Hong Lee, Neill R Graff-Radford, Jasmeer P Chhatwal, Randall J Bateman, John C Morris, Celeste M Karch, Oscar Harari & Carlos Cruchaga. Nature Neuroscience, Volume 22, Issue 11, 1 November 2019, Pages 1903-1912 Read More

Posted in: Axon Injury & Repair, Clocks & Sleep, HPAN, Neurodegeneration, Neurogenetics & Transcriptomics, Publications Faculty: , , , , , ,

A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain

Posted on August 23, 2019

Jorge L. Del-Aguila, Zeran Li, Umber Dube, Kathie A. Mihindukulasuriya, John P. Budde, Maria Victoria Fernandez, Laura Ibanez, Joseph Bradley, Fengxian Wang, Kristy Bergmann, Richard Davenport, John C. Morris, David M. Holtzman, Richard J. Perrin, Bruno A. Benitez, Joseph Dougherty, Carlos Cruchaga & Oscar Harari. Alzheimer’s Research and Therapy, Volume 11, Issue 1, 9 August 2019, Article number 71 Read More

Posted in: Clocks & Sleep, HPAN, Lysosome, Neurodegeneration, Neurogenetics & Transcriptomics, Publications Faculty: , , , , ,