News & Publications for:

Daniel Ory

Drug trial shows promise for deadly neurological disorder

Posted on August 17, 2017

Cyclodextrin slows progression of Niemann-Pick type C Read More

Posted in: HPAN, Lysosome, Neurodegeneration, News Faculty:

Rpl13a small nucleolar RNAs regulate systemic glucose metabolism

Posted on December 30, 2016

Lee J, Harris AN, Holley CL, et al: 2016 Journal of Clinical Investigation, 126(12), pp 4616-4625 Read More

Posted in: HPAN, Lysosome, Neurodegeneration, NeuroRestorative Therapy, Publications Faculty: ,

A murine Niemann-Pick C1 (NPC1) I1061T knockin model recapitulates the pathological features of the most prevalent human disease allele

Posted on October 20, 2016

Praggastis M, Tortelli B, Zhang J, Fujiwara H, Sidhu R, Chacko A, Chen Z, Lieberman AP, Davidson C, Walkley SU, Pipalia NH, Maxfield FR, Schaffer JE, and Ory DS: 2015 J Neuroscience, 35:8091-8106. PMCID: PMC4444535 Read More

Posted in: HPAN, Lysosome, Neurodegeneration, Publications Faculty:

Reduction of TMEM97 increases NPC1 protein levels and restores cholesterol trafficking in Niemann-Pick type C1 disease cells

Posted on July 4, 2016

Darius Ebrahimi-Fakhari, Lara Wahlster, Fabian Bartz, Jennifer Werenbeck-Ueding, Maria Praggastis, Jessie Zhang, Brigitte Joggerst-Thomalla, Susanne Theiss, Dirk Grimm, Daniel S. Ory: 2016 Hum Mol Genet (2016) 25 (16): 3588-3599 Read More

Posted in: HPAN, Lysosome, Neurodegeneration Faculty:

Development of a bile acid-based newborn screen for Niemann-Pick disease type C

Posted on June 5, 2016

Jiang X, Sidhu R, Mydock-McGrane L, et al: 2016 Science Translational Medicine, 8(337) Read More

Posted in: HPAN, Lysosome, Neurodegeneration, Publications Faculty: