News & Publications for:

David Holtzman

Incident cognitive impairment: longitudinal changes in molecular, structural and cognitive biomarkers

Posted on November 6, 2018

Catherine M Roe, Beau M Ances, Denise Head, Ganesh M Babulal, Sarah H Stout, Elizabeth A Grant, Jason Hassenstab, Chengjie Xiong, David M Holtzman, Tammie L S Benzinger, Suzanne E Schindler, Anne M Fagan, John C Morris. Brain : a journal of neurology, Volume 141, Issue 11, 1 November 2018, Pages 3233-3248 Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, Publications Faculty: , , ,

High-affinity interactions and signal transduction between Aβ oligomers and TREM2

Posted on November 3, 2018

Christian B Lessard, Samuel L Malnik, Yingyue Zhou, Thomas B Ladd, Pedro E Cruz, Yong Ran, Thomas E Mahan, Paramita Chakrabaty, David M Holtzman, Jason D Ulrich, Marco Colonna, Todd E Golde. EMBO Molecular Medicine, 2018, Article number e201809027 Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, Neurogenetics & Transcriptomics, Publications Faculty: ,

High-affinity interactions and signal transduction between Aβ oligomers and TREM2

Posted on November 1, 2018

Christian B Lessard, Samuel L Malnik, Yingyue Zhou, Thomas B Ladd, Pedro E Cruz, View ORCID ProfileYong Ran, Thomas E Mahan, Paramita Chakrabaty, David M Holtzman, Jason D Ulrich, Marco Colonna, Todd E Golde. EMBO Molecular Medicine 2018, Article number e201809027 Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, Neurogenetics & Transcriptomics Faculty: ,

Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein e isoform-specific mechanism

Posted on November 1, 2018

Qingyi Ma, Zhen Zhao, Abhay P Sagare, Yingxi Wu, Min Wang, Nelly Chuqui Owens, Philip B Verghese, Joachim Herz, David M Holtzman and Berislav V Zlokovic. Molecular Neurodegeneration, Volume 13, Issue 1, 19 October 2018, Article number 57 Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, Publications Faculty:

Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease

Posted on October 10, 2018

Eric McDade, Guoqiao Wang, Brian A. Gordon, Jason Hassenstab, Tammie L.S. Benzinger, Virginia Buckles, Anne M. Fagan, David M. Holtzman, Nigel J. Cairns, Alison M. Goate, Daniel S. Marcus, John C. Morris, Katrina Paumier, Chengjie Xiong, Ricardo Allegri, Sarah B. Berman, William Klunk, James Noble, John Ringman, Bernardino Ghetti, Martin Farlow, Reisa A. Sperling, Jasmeer Chhatwal, Stephen Salloway, Neill R. Graff-Radford, Peter R. Schofield, Colin Masters, Martin N. Rossor, Nick C. Fox, Johannes Levin, Mathias Jucker, Randall J. Bateman, for the Dominantly Inherited Alzheimer Network. Neurology, Volume 91, Issue 14, 2 October 2018, Pages e1295-e1306 Read More

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