News & Publications for:

David Holtzman

Protein involved in removing Alzheimer’s buildup linked to circadian rhythm

Posted on December 18, 2020

Brain protein helps explain link between circadian rhythm, Alzheimer’s disease Read More

Posted in: Clocks & Sleep, HPAN, News Faculty: , ,

Association of blood-based transcriptional risk scores with biomarkers for Alzheimer disease

Posted on December 14, 2020

Young Ho Park, Angela Hodges, Andrew Simmons, Simon Lovestone, Michael W. Weiner, SangYun Kim, Andrew J. Saykin, John Morris, […], Marcus Raichle, […], David Holtzman, […], Kwangsik Nho, For the AddNeuroMed consortium and the Alzheimer’s Disease Neuroimaging Initiative. Neurology: Genetics, Volume 6, Issue 6, December 2020, Article number e517 Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, Publications Faculty: , ,

Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis

Posted on December 14, 2020

Yun Chen, Michael R. Strickland, Andrea Soranno, David M. Holtzman. Neuron 2020 Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, Publications Faculty:

Functional insights from biophysical study of TREM2 interactions with apoE and Aβ1‐42

Posted on November 4, 2020

Daniel L. Kober, Melissa D. Stuchell‐Brereton, Colin E. Kluender, Hunter B. Dean, Michael R. Strickland, Deborah F. Steinberg, Samantha S. Nelson, Berevan Baban, David M. Holtzman, Carl Frieden, Jennifer Alexander‐Brett, Erik D. Roberson, Yuhua Song, Tom J. Brett. Alzheimers Dementia. 2020 Oct 8 Read More

Posted in: HPAN, Neurodegeneration, Publications Faculty: , ,

TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis

Posted on August 14, 2020

Francesca Cignarella, Fabia Filipello, Bryan Bollman, Claudia Cantoni, Alberto Locca, Robert Mikesell, Melissa Manis, Adiljan Ibrahim, Li Deng, Bruno A. Benitez, Carlos Cruchaga, Danilo Licastro, Kathie Mihindukulasuriya, Oscar Harari, Michael Buckland, David M. Holtzman, Arnon Rosenthal, Tina Schwabe, Ilaria Tassi & Laura Piccio. Acta Neuropathologica 2020 Read More

Posted in: Clocks & Sleep, Lysosome, Neurogenetics & Transcriptomics, Publications Faculty: , , ,