News & Publications for:

David Holtzman

Longitudinal brain imaging in preclinical Alzheimer disease: Impact of APOE ϵ4 genotype

Posted on June 14, 2018

Shruti Mishra, Tyler M Blazey, David M Holtzman, Carlos Cruchaga, Yi Su, John C Morris, Tammie L S Benzinger, Brian A Gordon. Brain, Volume 141, Issue 6, 1 June 2018, Pages 1828-1839 Read More

Posted in: Clocks & Sleep, HPAN, Lysosome, Neurodegeneration, Neurogenetics & Transcriptomics, Publications Faculty: , , ,

AMPA-ergic regulation of amyloid-β levels in an Alzheimer’s disease mouse model

Posted on May 31, 2018

Jane C. Hettinger, Hyo Lee, Guojun Bu, David M. Holtzman and John R. Cirrito. Molecular Neurodegeneration, Volume 13, Issue 1, 15 May 2018, Article number 22 Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, Publications Faculty: ,

White matter hyperintensities and the mediating role of cerebral amyloid angiopathy in dominantly-inherited Alzheimer’s disease

Posted on May 25, 2018

Seonjoo Lee, Molly E. Zimmerman, Atul Narkhede, Sara E. Nasrabady, Giuseppe Tosto, Irene B. Meier, Tammie L. S. Benzinger, Daniel S. Marcus, Anne M. Fagan, Nick C. Fox, Nigel J. Cairns, David M. Holtzman, Virginia Buckles, [ … ], Dominantly Inherited Alzheimer Network. PLoS ONE, Volume 13, Issue 5, May 2018, Article number e0195838 Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, Neurogenetics & Transcriptomics, Publications Faculty: , , , ,

Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation

Posted on May 17, 2018

Fan Liao, … and David M. Holtzman. Journal of Clinical Investigation, Volume 128, Issue 5, 1 May 2018, Pages 2144-2155 Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, Publications Faculty:

ApoE facilitates the microglial response to amyloid plaque pathology

Posted on April 14, 2018

Jason D. Ulrich, Tyler K. Ulland, Thomas E. Mahan, Sofie Nyström, K. Peter Nilsson, Wilbur M. Song, Yingyue Zhou, Mariska Reinartz, Seulah Choi, Hong Jiang, Floy R. Stewart, Elise Anderson, Yaming Wang, Marco Colonna, David M. Holtzman . Journal of Experimental Medicine, Volume 215, Issue 4, 1 April 2018, Pages 1047-1058 Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, Neurogenetics & Transcriptomics, Publications Faculty: ,