News & Publications for:

David Holtzman

Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

Posted on January 24, 2020

Yingyue Zhou, Wilbur M. Song, Prabhakar S. Andhey, Amanda Swain, Tyler Levy, Kelly R. Miller, Pietro L. Poliani, Manuela Cominelli, Shikha Grover, Susan Gilfillan, Marina Cella, Tyler K. Ulland, Konstantin Zaitsev, Akinori Miyashita, Takeshi Ikeuchi, Makoto Sainouchi, Akiyoshi Kakita, David A. Bennett, Julie A. Schneider, Michael R. Nichols, Sean A. Beausoleil, Jason D. Ulrich, David M. Holtzman, Maxim N. Artyomov & Marco Colonna . Nature Medicine, Volume 26, Issue 1, 1 January 2020, Pages 131-142 Read More

Posted in: Axon Injury & Repair, Clocks & Sleep, Neurodegeneration, Neurogenetics & Transcriptomics, Publications Faculty: , ,

Publisher Correction: Dietary salt promotes cognitive impairment through tau phosphorylation (Nature, (2019), 574, 7780, (686-690), 10.1038/s41586-019-1688-z)

Posted on January 23, 2020

Giuseppe Faraco, Karin Hochrainer, Steven G. Segarra, Samantha Schaeffer, Monica M. Santisteban, Ajay Menon, Hong Jiang, David M. Holtzman, Josef Anrather & Costantino Iadecola. Nature 2020 Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, Publications Faculty:

Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model

Posted on November 14, 2019

Yang Shi, Melissa Manis, Justin Long, Kairuo Wang, Patrick M. Sullivan, Javier Remolina Serrano, Rosa Hoyle, David M. Holtzman. The Journal of Experimental Medicine, Volume 216, Issue 11, 4 November 2019, Pages 2546-2561 Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, Publications Faculty:

Dietary salt promotes cognitive impairment through tau phosphorylation

Posted on November 7, 2019

Giuseppe Faraco, Karin Hochrainer, Steven G. Segarra, Samantha Schaeffer, Monica M. Santisteban, Ajay Menon, Hong Jiang, David M. Holtzman, Josef Anrather & Costantino Iadecola. Nature, Volume 574, Issue 7780, 31 October 2019, Pages 686-690 Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, Publications Faculty:

An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations

Posted on November 6, 2019

Umber Dube, Jorge L Del-Aguila, Zeran Li, John P Budde, Shan Jiang, Simon Hsu, Laura Ibanez, Maria Victoria Fernandez, Fabiana Farias, Joanne Norton, Jen Gentsch, Fengxian Wang, the Dominantly Inherited Alzheimer Network (DIAN), Stephen Salloway, Colin L Masters, Jae-Hong Lee, Neill R Graff-Radford, Jasmeer P Chhatwal, Randall J Bateman, John C Morris, Celeste M Karch, Oscar Harari & Carlos Cruchaga. Nature Neuroscience, Volume 22, Issue 11, 1 November 2019, Pages 1903-1912 Read More

Posted in: Axon Injury & Repair, Clocks & Sleep, HPAN, Neurodegeneration, Neurogenetics & Transcriptomics, Publications Faculty: , , , , , ,