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David Holtzman

David Holtzman‘s Faculty Page

TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis

Posted on August 14, 2020

Francesca Cignarella, Fabia Filipello, Bryan Bollman, Claudia Cantoni, Alberto Locca, Robert Mikesell, Melissa Manis, Adiljan Ibrahim, Li Deng, Bruno A. Benitez, Carlos Cruchaga, Danilo Licastro, Kathie Mihindukulasuriya, Oscar Harari, Michael Buckland, David M. Holtzman, Arnon Rosenthal, Tina Schwabe, Ilaria Tassi & Laura Piccio. Acta Neuropathologica 2020 Read More

Posted in: Clocks & Sleep, Lysosome, Neurogenetics & Transcriptomics, Publications Faculty: , , ,

A telescope GWAS analysis strategy, based on SNPs-genes-pathways ensamble and on multivariate algorithms, to characterize late onset Alzheimer’s disease

Posted on July 30, 2020

Margherita Squillario, Giulia Abate, Federico Tomasi, Veronica Tozzo, Annalisa Barla, Daniela Uberti & The Alzheimer’s Disease Neuroimaging Initiative. Scientific Reports, Volume 10, Issue 1, 1 December 2020, Article number 12063 Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, Publications Faculty: , ,

A telescope GWAS analysis strategy, based on SNPs-genes-pathways ensamble and on multivariate algorithms, to characterize late onset Alzheimer’s disease

Posted on July 29, 2020

Margherita Squillario, Giulia Abate, Federico Tomasi, Veronica Tozzo, Annalisa Barla, Daniela Uberti & The Alzheimer’s Disease Neuroimaging Initiative. Scientific Reports, Volume 10, Issue 1, 1 December 2020, Article number 12063 Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, Publications Faculty: , , ,

Gut Microbiota: From the Forgotten Organ to a Potential Key Player in the Pathology of Alzheimer’s Disease

Posted on July 2, 2020

Dong-Oh Seo, David M Holtzman. The Journals of Gerontology. Series A, Biological sciences and medical sciences, Volume 75, Issue 7, 18 June 2020, Pages 1232-1241 Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, Publications Faculty:

25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner

Posted on July 2, 2020

Man Ying Wong, Michael Lewis, James J. Doherty, Yang Shi, Anil G. Cashikar, Anna Amelianchik, Svitlana Tymchuk, Patrick M. Sullivan, Mingxing Qian, Douglas F. Covey, Gregory A. Petsko, David M. Holtzman, Steven M. Paul & Wenjie Luo. Journal of Neuroinflammation, Volume 17, Issue 1, 17 June 2020, Article number 192 Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, Publications Faculty: , ,