News & Publications for:

David Holtzman

A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain

Posted on August 23, 2019

Jorge L. Del-Aguila, Zeran Li, Umber Dube, Kathie A. Mihindukulasuriya, John P. Budde, Maria Victoria Fernandez, Laura Ibanez, Joseph Bradley, Fengxian Wang, Kristy Bergmann, Richard Davenport, John C. Morris, David M. Holtzman, Richard J. Perrin, Bruno A. Benitez, Joseph Dougherty, Carlos Cruchaga & Oscar Harari. Alzheimer’s Research and Therapy, Volume 11, Issue 1, 9 August 2019, Article number 71 Read More

Posted in: Clocks & Sleep, HPAN, Lysosome, Neurodegeneration, Neurogenetics & Transcriptomics, Publications Faculty: , , , , ,

High-precision plasma β-amyloid 42/40 predicts current and future brain amyloidosis

Posted on August 5, 2019

Suzanne E. Schindler, James G. Bollinger, Vitaliy Ovod, Kwasi G. Mawuenyega, Yan Li, Brian A. Gordon, David M. Holtzman, John C. Morris, Tammie L.S. Benzinger, Chengjie Xiong, Anne M. Fagan, Randall J. Bateman. Neurology 2019 Read More

Posted in: HPAN, Neurodegeneration, Neurogenetics & Transcriptomics, Publications Faculty: , , , ,

A Blood Test for Alzheimer’s? It’s Coming, Scientists Report

Posted on August 2, 2019

A test that measures beta amyloid protein in the blood is more accurate than a brain scan and may indicate trouble years earlier. Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, News Faculty: ,

TREM2 function impedes tau seeding in neuritic plaques

Posted on July 13, 2019

Cheryl E. G. Leyns, Maud Gratuze, Sneha Narasimhan, Nimansha Jain, Lauren J. Koscal, Hong Jiang, Melissa Manis, Marco Colonna, Virginia M. Y. Lee, Jason D. Ulrich & David M. Holtzman. Nature Neuroscience, volume 22, pages 1217–1222 (2019) Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, Neurogenetics & Transcriptomics, Publications Faculty: ,

Alzheimer’s missing link ID’d, answering what tips brain’s decline

Posted on June 24, 2019

Brain’s immune cells form nexus between two damaging Alzheimer’s proteins Read More

Posted in: Clocks & Sleep, HPAN, Neurodegeneration, News Faculty: